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Top Articles

#TitleJournalYearCitations
1An open science resource for establishing reliability and reproducibility in functional connectomicsScientific Data2014349
2Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortexEuropean Psychiatry2014310
3The Long Noncoding RNA HOTAIR Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma Cells via downregualtion of p21WAF1/CIP1 ExpressionPLoS ONE2013272
4MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14)Oncogene2011270
5ABCG2: A potential marker of stem cells and novel target in stem cell and cancer therapyLife Sciences2010261
6A Facile Multi-interface Transformation Approach to Monodisperse Multiple-Shelled Periodic Mesoporous Organosilica Hollow SpheresJournal of the American Chemical Society2015238
7Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat ModelNeurochemical Research2013231
8Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric CancerClinical Cancer Research2018204
9Efficient Bacteria Killing by Cu2WS4 Nanocrystals with Enzyme-like Properties and Bacteria-Binding AbilityACS Nano2019190
10Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential mechanismFree Radical Biology and Medicine2014187
11Facile Synthesis of Yolk–Shell Structured Inorganic–Organic Hybrid Spheres with Ordered Radial MesochannelsAdvanced Materials2014181
12Mesoporous Organosilica Hollow Nanoparticles: Synthesis and ApplicationsAdvanced Materials2019179
13Deformable Hollow Periodic Mesoporous Organosilica Nanocapsules for Significantly Improved Cellular UptakeJournal of the American Chemical Society2018168
14Progress and Prospects of Long Noncoding RNAs (lncRNAs) in Hepatocellular CarcinomaCellular Physiology and Biochemistry2015167
15Mapping 123 million neonatal, infant and child deaths between 2000 and 2017Nature2019161
16An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticlesNanoscale2015157
17Serum Interleukin-6 Is a Predictive Biomarker for Ketamine’s Antidepressant Effect in Treatment-Resistant Patients With Major DepressionBiological Psychiatry2015155
18Doxorubicin-loaded NaYF4:Yb/Tm–TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancersBiomaterials2015154
19The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured AstrocytesMediators of Inflammation2012149
20κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain Injury">Disruption of Nrf2 Enhances Upregulation of Nuclear Factor-κB Activity, Proinflammatory Cytokines, and Intercellular Adhesion Molecule-1 in the Brain after Traumatic Brain InjuryMediators of Inflammation2008144
21Hypoxia-Targeting, Tumor Microenvironment Responsive Nanocluster Bomb for Radical-Enhanced RadiotherapyACS Nano2017142
22Tailoring the component of protein corona via simple chemistryNature Communications2019142
23Systematic review and meta-analysis of triclosan-coated sutures for the prevention of surgical-site infectionBritish Journal of Surgery2013141
24Multiple Mechanisms of Anti-Cancer Effects Exerted by AstaxanthinMarine Drugs2015141
25Selectively Sensitizing Malignant Cells to Photothermal Therapy Using a CD44-Targeting Heat Shock Protein 72 Depletion NanosystemACS Nano2016141
26Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming testUpsala Journal of Medical Sciences2013140
27Hopeahainol A: An Acetylcholinesterase Inhibitor from Hopea hainanensisChemistry - A European Journal2008138
28Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain InjuryMarine Drugs2014135
29Non-Target and Suspect Screening of Per- and Polyfluoroalkyl Substances in Airborne Particulate Matter in ChinaEnvironmental Science & Technology2018133
30Overcoming Hypoxia by Multistage Nanoparticle Delivery System to Inhibit Mitochondrial Respiration for Photodynamic TherapyAdvanced Functional Materials2019132
31HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinomaMolecular Cancer2014130
32Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathwaysScientific Reports2017130
33Inhibitory Effect on Cerebral Inflammatory Response following Traumatic Brain Injury in Rats: A Potential Neuroprotective Mechanism of N-AcetylcysteineMediators of Inflammation2008129
34Inhibition of cathepsin S induces autophagy and apoptosis in human glioblastoma cell lines through ROS-mediated PI3K/AKT/mTOR/p70S6K and JNK signaling pathwaysToxicology Letters2014128
35Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitroJournal of Neuroinflammation2014126
36The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human CancersCellular Physiology and Biochemistry2016126
37Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging miceJournal of Neuroinflammation2020125
38The promotion of neural regeneration in an extreme rat spinal cord injury model using a collagen scaffold containing a collagen binding neuroprotective protein and an EGFR neutralizing antibodyBiomaterials2010123
39The linear-ordered collagen scaffold-BDNF complex significantly promotes functional recovery after completely transected spinal cord injury in canineBiomaterials2015123
40New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implicationsMolecular Cancer2018123
41Advances of injectable hydrogel-based scaffolds for cartilage regenerationInternational Journal of Energy Production and Management2019120
42Association of Estrogen Receptor Gene Polymorphisms With Susceptibility to Adolescent Idiopathic ScoliosisSpine2006119
43Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of ratsProgress in Neuro-Psychopharmacology and Biological Psychiatry2009118
44MicroRNA‐200b reverses chemoresistance of docetaxel‐resistant human lung adenocarcinoma cells by targeting E2F3Cancer2012118
45MicroRNA‐145: a potent tumour suppressor that regulates multiple cellular pathwaysJournal of Cellular and Molecular Medicine2014118
46Long non‐coding RNAs in non‐small cell lung cancer as biomarkers and therapeutic targetsJournal of Cellular and Molecular Medicine2014116
47Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like BehaviorsFrontiers in Neuroscience2017116
48Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancersBiomaterials2015114
49Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in ratsCell Death and Disease2016112
50Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of TumorsAdvanced Science2018111