| # | Title | Journal | Year | Citations |
|---|
| 1 | Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells | Nature Biotechnology | 2014 | 1,253 |
| 2 | Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans | Immunological Reviews | 2006 | 1,071 |
| 3 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) | European Journal of Immunology | 2019 | 766 |
| 4 | Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production | International Immunology | 2007 | 756 |
| 5 | Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells | Nature Medicine | 2011 | 714 |
| 6 | Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy (the ASCENDE-RT Trial): An Analysis of Survival Endpoints for a Randomized Trial Comparing a Low-Dose-Rate Brachytherapy Boost to a Dose-Escalated External Beam Boost for High- and Intermediate-risk Prostate Cancer | International Journal of Radiation Oncology Biology Physics | 2017 | 606 |
| 7 | Guidelines for the use of flow cytometry and cell sorting in immunological studies* | European Journal of Immunology | 2017 | 505 |
| 8 | Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice | Diabetes | 2012 | 493 |
| 9 | Radiofrequency Ablation of Porcine Liver In Vivo | Annals of Surgery | 1998 | 446 |
| 10 | A Systematic Review of the Effects of Resident Duty Hour Restrictions in Surgery | Annals of Surgery | 2014 | 436 |
| 11 | Competency Is Not Enough | Academic Medicine | 2012 | 429 |
| 12 | Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin Production | Cell Metabolism | 2012 | 420 |
| 13 | Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing | Advances in Wound Care | 2013 | 415 |
| 14 | The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs | Journal of Clinical Investigation | 2005 | 386 |
| 15 | Effects of intermittent androgen suppression on androgen-dependent tumors. Apoptosis and serum prostate-specific antigen | Cancer | 1993 | 381 |
| 16 | Arterial aneurysms associated with cerebral arteriovenous malformations: classification, incidence, and risk of hemorrhage | Journal of Neurosurgery | 1998 | 350 |
| 17 | Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss | Laryngoscope | 2010 | 338 |
| 18 | CD161 is a marker of all human IL‐17‐producing T‐cell subsets and is induced by RORC | European Journal of Immunology | 2010 | 333 |
| 19 | Justify your alpha | Nature Human Behaviour | 2018 | 310 |
| 20 | Canada's universal health-care system: achieving its potential | Lancet, The | 2018 | 298 |
| 21 | Intermittent androgen suppression in the treatment of prostate cancer: A preliminary report | Urology | 1995 | 289 |
| 22 | A protocol for islet isolation from mouse pancreas | Nature Protocols | 2009 | 289 |
| 23 | American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults | Thyroid | 2018 | 270 |
| 24 | Caveolin-1 in tumor progression: the good, the bad and the ugly | Cancer and Metastasis Reviews | 2008 | 263 |
| 25 | Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients | Clinical Cancer Research | 2006 | 256 |
| 26 | Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation | Journal of Biological Chemistry | 2003 | 248 |
| 27 | Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options | Journal of Otolaryngology - Head and Neck Surgery | 2017 | 239 |
| 28 | Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo | Stem Cells | 2013 | 233 |
| 29 | Renal Colic in Pregnancy | Journal of Urology | 1992 | 232 |
| 30 | Intraoperative facial motor evoked potential monitoring with transcranial electrical stimulation during skull base surgery | Clinical Neurophysiology | 2005 | 230 |
| 31 | Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response | | 2018 | 230 |
| 32 | Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease | Clinical and Experimental Immunology | 2009 | 227 |
| 33 | A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women | Canadian Journal of Urology | 2002 | 227 |
| 34 | Indocyanine green clearance as a predictor of successful hepatic resection in cirrhotic patients | American Journal of Surgery | 1992 | 213 |
| 35 | Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3 | Molecular Therapy | 2008 | 206 |
| 36 | Surgical Fixation vs Nonoperative Management of Flail Chest: A Meta-Analysis | Journal of the American College of Surgeons | 2013 | 206 |
| 37 | American Thyroid Association Statement on Surgical Application of Molecular Profiling for Thyroid Nodules: Current Impact on Perioperative Decision Making | Thyroid | 2015 | 204 |
| 38 | Why are women deterred from general surgery training? | American Journal of Surgery | 2005 | 199 |
| 39 | Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) | European Journal of Immunology | 2021 | 198 |
| 40 | Determinants of occupational disability following a low back injury: a critical review of the literature | Journal of Occupational Rehabilitation | 2002 | 196 |
| 41 | Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells | Blood | 2007 | 196 |
| 42 | Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet | Diabetologia | 2010 | 196 |
| 43 | A multicenter review of the treatment of major truncal necrotizing infections with and without hyperbaric oxygen therapy | American Journal of Surgery | 1994 | 192 |
| 44 | Potential application of gaseous nitric oxide as a topical antimicrobial agent | Nitric Oxide - Biology and Chemistry | 2006 | 190 |
| 45 | Factors affecting cervical anastomotic leak and stricture formation following esophagogastrectomy and gastric tube interposition | American Journal of Surgery | 1992 | 189 |
| 46 | Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans | Journal of Immunology | 2013 | 189 |
| 47 | Reduced Progression of Diabetic Microvascular Complications With Islet Cell Transplantation Compared With Intensive Medical Therapy | Transplantation | 2011 | 185 |
| 48 | Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells | Diabetes | 2011 | 183 |
| 49 | Simple Decompression Versus Anterior Subcutaneous and Submuscular Transposition of the Ulnar Nerve for Cubital Tunnel Syndrome: A Meta-Analysis | Journal of Hand Surgery | 2008 | 180 |
| 50 | Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice | Diabetologia | 2013 | 177 |
