| # | Title | Journal | Year | Citations |
|---|
| 1 | Human gut microbiome viewed across age and geography | Nature | 2012 | 6,247 |
| 2 | Glutamate and the pathophysiology of hypoxic-ischemic brain damage | Annals of Neurology | 1986 | 2,369 |
| 3 | Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study | Lancet, The | 2009 | 1,327 |
| 4 | CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance | Nature | 2013 | 1,119 |
| 5 | Regulation of Intestinal -Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense | Science | 1999 | 1,041 |
| 6 | Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy | Nature Reviews Neuroscience | 2009 | 967 |
| 7 | Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria | Nature Immunology | 2000 | 939 |
| 8 | Association of In Vitro Fertilization with Beckwith-Wiedemann Syndrome and Epigenetic Alterations of LIT1 and H19 | American Journal of Human Genetics | 2003 | 875 |
| 9 | JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome | Journal of Clinical Investigation | 2000 | 792 |
| 10 | The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor | New England Journal of Medicine | 1997 | 737 |
| 11 | Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury | Cell | 2002 | 706 |
| 12 | Neurturin, a relative of glial-cell-line-derived neurotrophic factor | Nature | 1996 | 688 |
| 13 | Myristoylation-dependent replication and assembly of human immunodeficiency virus 1. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 651 |
| 14 | Matrix metalloproteinase degradation of extracellular matrix: biological consequences | Current Opinion in Cell Biology | 1998 | 648 |
| 15 | TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function | Immunity | 2004 | 644 |
| 16 | Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma | New England Journal of Medicine | 1993 | 639 |
| 17 | Two modes of radial migration in early development of the cerebral cortex | Nature Neuroscience | 2001 | 621 |
| 18 | Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia | Science Translational Medicine | 2016 | 621 |
| 19 | Incidence of BK with Tacrolimus Versus Cyclosporine and Impact of Preemptive Immunosuppression Reduction | American Journal of Transplantation | 2005 | 613 |
| 20 | Deficiency of Pulmonary Surfactant Protein B in Congenital Alveolar Proteinosis | New England Journal of Medicine | 1993 | 596 |
| 21 | Skeletal and Cardiac Myopathies in Mice Lacking Utrophin and Dystrophin: A Model for Duchenne Muscular Dystrophy | Cell | 1997 | 588 |
| 22 | Similar patterns of cortical expansion during human development and evolution | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 588 |
| 23 | Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections | PLoS Pathogens | 2007 | 581 |
| 24 | International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. | Journal of Clinical Oncology | 1988 | 564 |
| 25 | Biogeography of the ecosystems of the healthy human body | Genome Biology | 2013 | 540 |
| 26 | Early life dynamics of the human gut virome and bacterial microbiome in infants | Nature Medicine | 2015 | 523 |
| 27 | Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults | Nature Communications | 2016 | 523 |
| 28 | The Mechanism of Insulin Resistance Caused by HIV Protease Inhibitor Therapy | Journal of Biological Chemistry | 2000 | 507 |
| 29 | Cytokine activation induces human memory-like NK cells | Blood | 2012 | 492 |
| 30 | Radioimmunoassay of leptin in human plasma | Clinical Chemistry | 1996 | 488 |
| 31 | Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain | Nature | 1986 | 484 |
| 32 | American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock | Critical Care Medicine | 2017 | 475 |
| 33 | Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML | Blood | 2009 | 467 |
| 34 | Statistical improvements in functional magnetic resonance imaging analyses produced by censoring high‐motion data points | Human Brain Mapping | 2014 | 457 |
| 35 | GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys | Neuron | 1998 | 443 |
| 36 | N-Heterocyclic carbene–silver complexes: A new class of antibiotics | Coordination Chemistry Reviews | 2007 | 439 |
| 37 | Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 434 |
| 38 | Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons | Cell | 1999 | 431 |
| 39 | THE UBIQUITIN-PROTEASOME PATHWAY AND PATHOGENESIS OF HUMAN DISEASES | Annual Review of Medicine | 1999 | 426 |
| 40 | Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis | Journal of Allergy and Clinical Immunology | 2020 | 419 |
| 41 | Neonatal intensive care unit stress is associated with brain development in preterm infants | Annals of Neurology | 2011 | 418 |
| 42 | Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays | Gut | 2015 | 410 |
| 43 | Measurement of “True” Glucose Production Rates in Infancy and Childhood with 6,6-Dideuteroglucose | Diabetes | 1977 | 396 |
| 44 | Acquisition of Murine NK Cell Cytotoxicity Requires the Translation of a Pre-existing Pool of Granzyme B and Perforin mRNAs | Immunity | 2007 | 391 |
| 45 | The microbial metabolite desaminotyrosine protects from influenza through type I interferon | Science | 2017 | 391 |
| 46 | Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung | Journal of Experimental Medicine | 2000 | 383 |
| 47 | Classifying Asthma Severity in Children | American Journal of Respiratory and Critical Care Medicine | 2004 | 381 |
| 48 | Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome | Genetics in Medicine | 2009 | 376 |
| 49 | Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts | Lancet Respiratory Medicine,the | 2016 | 375 |
| 50 | Expression and function of TRK-B and BDNF in human neuroblastomas. | Molecular and Cellular Biology | 1994 | 368 |
