| # | Title | Journal | Year | Citations |
|---|
| 1 | ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 8,654 |
| 2 | Parkinson's disease | Lancet, The | 2015 | 4,079 |
| 3 | A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD | Neuron | 2011 | 3,833 |
| 4 | Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice | Nature | 1995 | 3,666 |
| 5 | Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries | JAMA - Journal of the American Medical Association | 2016 | 3,568 |
| 6 | SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials | BMJ, The | 2013 | 3,435 |
| 7 | Parkinson disease | Nature Reviews Disease Primers | 2017 | 3,048 |
| 8 | Biology of Incretins: GLP-1 and GIP | Gastroenterology | 2007 | 2,918 |
| 9 | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology | Canadian Journal of Gastroenterology & Hepatology | 2005 | 2,711 |
| 10 | Functional Disability 5 Years after Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2011 | 2,228 |
| 11 | Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 1,855 |
| 12 | The biology of incretin hormones | Cell Metabolism | 2006 | 1,824 |
| 13 | Angiotensin-converting enzyme 2 is an essential regulator of heart function | Nature | 2002 | 1,586 |
| 14 | Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study | New England Journal of Medicine | 2004 | 1,581 |
| 15 | Carotenoids and human health | Pharmacological Research | 2007 | 1,530 |
| 16 | Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells | Nature Medicine | 2003 | 1,482 |
| 17 | Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease | Nature | 2000 | 1,472 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 19 | A Prospective Study of Venous Thromboembolism after Major Trauma | New England Journal of Medicine | 1994 | 1,367 |
| 20 | Evidence-Based Diagnosis, Staging, and Treatment of Patients With Hepatocellular Carcinoma | Gastroenterology | 2016 | 1,365 |
| 21 | Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial | Lancet, The | 2014 | 1,361 |
| 22 | Newcastle-Ottawa Scale: comparing reviewers’ to authors’ assessments | BMC Medical Research Methodology | 2014 | 1,327 |
| 23 | Normalization of obesity-associated insulin resistance through immunotherapy | Nature Medicine | 2009 | 1,217 |
| 24 | High-Frequency Oscillation in Early Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2013 | 1,209 |
| 25 | Tidal ventilation at low airway pressures can augment lung injury. | American Journal of Respiratory and Critical Care Medicine | 1994 | 1,149 |
| 26 | Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | Nature Genetics | 2010 | 1,132 |
| 27 | Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography | Intensive Care Medicine | 2008 | 1,130 |
| 28 | The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material | Intensive Care Medicine | 2012 | 1,112 |
| 29 | Pharmacological Treatment of Parkinson Disease | JAMA - Journal of the American Medical Association | 2014 | 1,097 |
| 30 | Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure | New England Journal of Medicine | 2005 | 1,093 |
| 31 | Quality End-of-Life Care | JAMA - Journal of the American Medical Association | 1999 | 1,090 |
| 32 | Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action | Cell Metabolism | 2013 | 1,088 |
| 33 | Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes | Endocrine Reviews | 2002 | 1,046 |
| 34 | Wound bed preparation: a systematic approach to wound management | Wound Repair and Regeneration | 2003 | 1,045 |
| 35 | The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease | Nature Genetics | 2007 | 1,045 |
| 36 | Risk Factors for Central and Obstructive Sleep Apnea in 450 Men And Women with Congestive Heart Failure | American Journal of Respiratory and Critical Care Medicine | 1999 | 1,040 |
| 37 | Decreased Susceptibility ofStreptococcus pneumoniaeto Fluoroquinolones in Canada | New England Journal of Medicine | 1999 | 995 |
| 38 | Mortality among Patients Admitted to Hospitals on Weekends as Compared with Weekdays | New England Journal of Medicine | 2001 | 990 |
| 39 | Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study | Lancet, The | 2008 | 960 |
| 40 | Association between Cellular-Telephone Calls and Motor Vehicle Collisions | New England Journal of Medicine | 1997 | 957 |
| 41 | Not all patients want to participate in decision making | Journal of General Internal Medicine | 2005 | 927 |
| 42 | Interpreting small differences in functional status: the Six Minute Walk test in chronic lung disease patients. | American Journal of Respiratory and Critical Care Medicine | 1997 | 904 |
| 43 | Evaluation of a Ventilation Strategy to Prevent Barotrauma in Patients at High Risk for Acute Respiratory Distress Syndrome | New England Journal of Medicine | 1998 | 899 |
| 44 | International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia | Journal of Medical Genetics | 2011 | 887 |
| 45 | Risk Factors for Extubation Failure in Patients Following a Successful Spontaneous Breathing Trial | Chest | 2006 | 885 |
| 46 | Zika virus in the Americas: Early epidemiological and genetic findings | Science | 2016 | 877 |
| 47 | Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study | Lancet, The | 2005 | 873 |
| 48 | Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE) | Lancet, The | 2000 | 866 |
| 49 | Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 | Cell Metabolism | 2018 | 866 |
| 50 | Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity | Nature Genetics | 2012 | 848 |
