| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia | Blood | 2016 | 7,429 |
| 2 | The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes | Blood | 2009 | 3,864 |
| 3 | Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial | Lancet, The | 2016 | 3,077 |
| 4 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation | Cancer Cell | 2010 | 2,328 |
| 5 | Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab | Cell | 2017 | 1,515 |
| 6 | A gene-based association method for mapping traits using reference transcriptome data | Nature Genetics | 2015 | 1,473 |
| 7 | Up-Regulation of PD-L1, IDO, and T regs in the Melanoma Tumor Microenvironment Is Driven by CD8 + T Cells | Science Translational Medicine | 2013 | 1,447 |
| 8 | pRRophetic: An R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels | PLoS ONE | 2014 | 1,363 |
| 9 | The molecular portraits of breast tumors are conserved across microarray platforms | BMC Genomics | 2006 | 1,169 |
| 10 | FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase | Cancer Cell | 2017 | 1,139 |
| 11 | The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response | Cell | 1998 | 1,138 |
| 12 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 13 | Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors | Genome Biology | 2007 | 1,009 |
| 14 | Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells | Journal of Experimental Medicine | 2011 | 959 |
| 15 | BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros | Nature | 2008 | 955 |
| 16 | Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine | Nature Biotechnology | 2011 | 955 |
| 17 | Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma | Modern Pathology | 2006 | 932 |
| 18 | Dnmt3a is essential for hematopoietic stem cell differentiation | Nature Genetics | 2012 | 916 |
| 19 | Association Between Bone Marrow Dosimetric Parameters and Acute Hematologic Toxicity in Anal Cancer Patients Treated With Concurrent Chemotherapy and Intensity-Modulated Radiotherapy | International Journal of Radiation Oncology Biology Physics | 2008 | 787 |
| 20 | 5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging | Nature Neuroscience | 2011 | 746 |
| 21 | Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis | Nature Genetics | 2012 | 692 |
| 22 | PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells | Cancer Research | 2004 | 679 |
| 23 | Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies | Blood | 2009 | 661 |
| 24 | The immune score as a new possible approach for the classification of cancer | Journal of Translational Medicine | 2012 | 656 |
| 25 | Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series | Blood | 2003 | 630 |
| 26 | Lung cancer | Lancet, The | 2000 | 606 |
| 27 | Inflammation, Growth Factors, and Pulmonary Vascular Remodeling | Journal of the American College of Cardiology | 2009 | 605 |
| 28 | Axitinib Is an Active Treatment for All Histologic Subtypes of Advanced Thyroid Cancer: Results From a Phase II Study | Journal of Clinical Oncology | 2008 | 593 |
| 29 | Phase II Trial of ZD1839 in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | Journal of Clinical Oncology | 2003 | 568 |
| 30 | Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells | Science | 2008 | 558 |
| 31 | Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer | JAMA Oncology | 2019 | 557 |
| 32 | Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study | Annals of Oncology | 2019 | 538 |
| 33 | Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation | Blood | 2013 | 537 |
| 34 | Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas | Clinical Cancer Research | 2015 | 525 |
| 35 | Combination cediranib and olaparib versus olaparib alone for women with recurrent platinum-sensitive ovarian cancer: a randomised phase 2 study | Lancet Oncology, The | 2014 | 523 |
| 36 | What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies | Blood | 2008 | 479 |
| 37 | Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1 | Nature Genetics | 2004 | 470 |
| 38 | Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations | Genomics | 1991 | 465 |
| 39 | Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer | FASEB Journal | 2012 | 458 |
| 40 | Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer | Annals of Oncology | 2019 | 456 |
| 41 | Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration | Journal of Clinical Oncology | 2020 | 448 |
| 42 | Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase II KEYNOTE-086 study | Annals of Oncology | 2019 | 419 |
| 43 | The Next Hurdle in Cancer Immunotherapy: Overcoming the Non–T-Cell–Inflamed Tumor Microenvironment | Seminars in Oncology | 2015 | 388 |
| 44 | Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 368 |
| 45 | Blocked Ras Activation in Anergic CD4+ T Cells | Science | 1996 | 367 |
| 46 | Apoptosis Meets Signal Transduction: Elimination of a BAD Influence | Cell | 1996 | 341 |
| 47 | Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping | Nature Genetics | 1997 | 341 |
| 48 | Population Differences in Breast Cancer: Survey in Indigenous African Women Reveals Over-Representation of Triple-Negative Breast Cancer | Journal of Clinical Oncology | 2009 | 341 |
| 49 | APOPTOSIS AND DISEASE: Regulation and Clinical Relevance of Programmed Cell Death | Annual Review of Medicine | 1997 | 335 |
| 50 | MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3) | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 319 |
