# | Title | Journal | Year | Citations |
---|
1 | Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer | Science | 2015 | 6,756 |
2 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma | Journal of Thoracic Oncology | 2011 | 4,127 |
3 | Tumour exosome integrins determine organotropic metastasis | Nature | 2015 | 3,688 |
4 | The 2015 World Health Organization Classification of Lung Tumors | Journal of Thoracic Oncology | 2015 | 3,313 |
5 | Integrative Genomic Profiling of Human Prostate Cancer | Cancer Cell | 2010 | 3,151 |
6 | Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain | PLoS Medicine | 2005 | 3,022 |
7 | Tumor mutational load predicts survival after immunotherapy across multiple cancer types | Nature Genetics | 2019 | 2,702 |
8 | Genomic analyses identify molecular subtypes of pancreatic cancer | Nature | 2016 | 2,700 |
9 | Integrative Clinical Genomics of Advanced Prostate Cancer | Cell | 2015 | 2,660 |
10 | Genes that mediate breast cancer metastasis to lung | Nature | 2005 | 2,581 |
11 | Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients | Nature Medicine | 2017 | 2,473 |
12 | Tumour invasion and metastasis initiated by microRNA-10b in breast cancer | Nature | 2007 | 2,382 |
13 | Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks | Nature Medicine | 2001 | 2,352 |
14 | The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours | European Urology | 2016 | 2,211 |
15 | Whole genomes redefine the mutational landscape of pancreatic cancer | Nature | 2015 | 2,132 |
16 | The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014 | Annals of Oncology | 2015 | 2,122 |
17 | Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia | Science Translational Medicine | 2014 | 2,069 |
18 | Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing | Nature Biotechnology | 2013 | 1,785 |
19 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate | Cancer Cell | 2010 | 1,754 |
20 | CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia | Science Translational Medicine | 2013 | 1,748 |
21 | Endogenous human microRNAs that suppress breast cancer metastasis | Nature | 2008 | 1,743 |
22 | Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer | Cell | 2017 | 1,742 |
23 | Comprehensive genomic profiles of small cell lung cancer | Nature | 2015 | 1,634 |
24 | Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer | Nature | 2012 | 1,605 |
25 | Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing | Cell | 2012 | 1,591 |
26 | Genes that mediate breast cancer metastasis to the brain | Nature | 2009 | 1,587 |
27 | Organoid Models of Human and Mouse Ductal Pancreatic Cancer | Cell | 2015 | 1,584 |
28 | Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) | Journal of Molecular Diagnostics | 2015 | 1,566 |
29 | MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 1,557 |
30 | REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants | American Journal of Human Genetics | 2016 | 1,555 |
31 | Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice | Immunity | 1995 | 1,545 |
32 | DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors | Science | 2011 | 1,504 |
33 | Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma | Nature Genetics | 2015 | 1,491 |
34 | Pten is essential for embryonic development and tumour suppression | Nature Genetics | 1998 | 1,428 |
35 | The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 | Cell | 1998 | 1,412 |
36 | KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib | PLoS Medicine | 2005 | 1,331 |
37 | The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours | European Urology | 2016 | 1,323 |
38 | Clinical-grade computational pathology using weakly supervised deep learning on whole slide images | Nature Medicine | 2019 | 1,320 |
39 | Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart | Journal of Thoracic Oncology | 2015 | 1,301 |
40 | Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. | Journal of Clinical Oncology | 1996 | 1,289 |
41 | The AIDS dementia complex: II. Neuropathology | Annals of Neurology | 1986 | 1,224 |
42 | miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis | Nature Cell Biology | 2010 | 1,216 |
43 | Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice | Science | 2001 | 1,194 |
44 | Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma | JAMA Oncology | 2016 | 1,192 |
45 | Organoid Cultures Derived from Patients with Advanced Prostate Cancer | Cell | 2014 | 1,184 |
46 | Phosphorylation and Functional Inactivation of TSC2 by Erk | Cell | 2005 | 1,132 |
47 | STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma | Cancer Discovery | 2018 | 1,108 |
48 | Punctuated Evolution of Prostate Cancer Genomes | Cell | 2013 | 1,107 |
49 | Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer | Nature Genetics | 2012 | 1,049 |
50 | Immunotherapy in colorectal cancer: rationale, challenges and potential | Nature Reviews Gastroenterology and Hepatology | 2019 | 1,039 |