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Top Articles

#TitleJournalYearCitations
1Quinone chemistry and toxicityToxicology and Applied Pharmacology1992697
2Diels-alder reactions of azadienesTetrahedron1983625
3Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detailProceedings of the National Academy of Sciences of the United States of America2001441
4Molecular basis for the herbicide resistance of Roundup Ready cropsProceedings of the National Academy of Sciences of the United States of America2006300
5Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001Nature2012284
6Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding PocketCurrent Medicinal Chemistry2008283
7The internal quaternary ammonium receptor site of Shaker potassium channelsNeuron1993258
8Roles of key active-site residues in flavocytochrome P450 BM3Biochemical Journal1999256
9Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic MetabolismJournal of Biological Chemistry2013229
10Chemistry of Bridged Lactams and Related HeterocyclesChemical Reviews2013223
11Novobiocin:  Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90Journal of the American Chemical Society2006221
12Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthasesBBA - Proteins and Proteomics1998205
13S-Adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapyJournal of Medicinal Chemistry1991201
14The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitorsMedicinal Research Reviews2000198
15A Modern Look at Folkloric Use of Anti-infective AgentsJournal of Natural Products1987192
16A Convenient Method for the Efficient Removal of Ruthenium Byproducts Generated during Olefin Metathesis ReactionsOrganic Letters2001187
17Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl:  Scope and Mechanistic InsightJournal of the American Chemical Society2007187
18Structures of Human Cytochrome P-450 2E1Journal of Biological Chemistry2008186
19Formulation Design and Photochemical Studies on Nanocrystal Solid Dispersion of Curcumin with Improved Oral BioavailabilityJournal of Pharmaceutical Sciences2010174
20Hsp90 Inhibitors Identified from a Library of Novobiocin AnaloguesJournal of the American Chemical Society2005173
21Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone FunctionMolecular Cell2010165
22Palladium(II)-Catalyzed Direct Arylation of Enaminones Using OrganotrifluoroboratesJournal of the American Chemical Society2008162
23A structural model for actin-induced nucleotide release in myosinNature Structural and Molecular Biology2003159
24Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat HepatocytesChemical Research in Toxicology2012159
25Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative AgentsJournal of Medicinal Chemistry2011157
26Diels-alder cycloaddition reactions of cyclopropenone ketalsTetrahedron1986152
27MARK4 Is a Novel Microtubule-associated Proteins/Microtubule Affinity-regulating Kinase That Binds to the Cellular Microtubule Network and to CentrosomesJournal of Biological Chemistry2004151
28Chemoprotection: A review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituentsMedicinal Research Reviews1997150
29Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity RelationshipsJournal of Medicinal Chemistry2008146
30Analytical considerations for microdialysis samplingAdvanced Drug Delivery Reviews2000145
31Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activityBiochemical Pharmacology2012143
32A Novel and Expeditious Reduction of Tertiary Amides to Aldehydes Using Cp2Zr(H)ClJournal of the American Chemical Society2000141
33Polyhydroxylated C60, fullerenols, as glutamate receptor antagonists and neuroprotective agentsJournal of Neuroscience Research2000140
34The Design, Synthesis, and Evaluation of Coumarin Ring Derivatives of the Novobiocin Scaffold that Exhibit Antiproliferative ActivityJournal of Organic Chemistry2008136
35Epothilone and Paclitaxel:  Unexpected Differences in Promoting the Assembly and Stabilization of Yeast Microtubules†Biochemistry2002135
36Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neuronsJournal of Neuroscience Research2001134
37Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline AnaloguesJournal of Medicinal Chemistry2010131
38Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanolOrganic Letters2015127
39Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid ReceptorsJournal of Biological Chemistry2013123
40Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodynEuropean Journal of Pharmacology2007121
41Development of Novobiocin Analogues That Manifest Anti-proliferative Activity against Several Cancer Cell LinesJournal of Organic Chemistry2008121
42R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant AbuseBiological Psychiatry2012121
43Reactions of Alkyl Azides and Ketones as Mediated by Lewis Acids:  Schmidt and Mannich Reactions Using Azide PrecursorsJournal of the American Chemical Society2000120
44Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorumDrug and Alcohol Dependence2011120
45Gambogic Acid, a Natural Product Inhibitor of Hsp90Journal of Natural Products2011120
46Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by ApoptosisJournal of Biological Chemistry2013120
47Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral RibonucleosidesPLoS Pathogens2012119
48Evidence That the Fosfomycin Target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA) Is Essential for Product ReleaseJournal of Biological Chemistry2005117
49Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 → Ile and Pro101 → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coliJournal of Biological Chemistry2009117
50Peptide Kappa Opioid Receptor Ligands: Potential for Drug DevelopmentAAPS Journal2009114