# | Title | Journal | Year | Citations |
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1 | Quinone chemistry and toxicity | Toxicology and Applied Pharmacology | 1992 | 697 |
2 | Diels-alder reactions of azadienes | Tetrahedron | 1983 | 625 |
3 | Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 441 |
4 | Molecular basis for the herbicide resistance of Roundup Ready crops | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 300 |
5 | Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001 | Nature | 2012 | 284 |
6 | Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket | Current Medicinal Chemistry | 2008 | 283 |
7 | The internal quaternary ammonium receptor site of Shaker potassium channels | Neuron | 1993 | 258 |
8 | Roles of key active-site residues in flavocytochrome P450 BM3 | Biochemical Journal | 1999 | 256 |
9 | Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism | Journal of Biological Chemistry | 2013 | 229 |
10 | Chemistry of Bridged Lactams and Related Heterocycles | Chemical Reviews | 2013 | 223 |
11 | Novobiocin: Redesigning a DNA Gyrase Inhibitor for Selective Inhibition of Hsp90 | Journal of the American Chemical Society | 2006 | 221 |
12 | Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases | BBA - Proteins and Proteomics | 1998 | 205 |
13 | S-Adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy | Journal of Medicinal Chemistry | 1991 | 201 |
14 | The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors | Medicinal Research Reviews | 2000 | 198 |
15 | A Modern Look at Folkloric Use of Anti-infective Agents | Journal of Natural Products | 1987 | 192 |
16 | A Convenient Method for the Efficient Removal of Ruthenium Byproducts Generated during Olefin Metathesis Reactions | Organic Letters | 2001 | 187 |
17 | Mild and Selective Hydrozirconation of Amides to Aldehydes Using Cp2Zr(H)Cl: Scope and Mechanistic Insight | Journal of the American Chemical Society | 2007 | 187 |
18 | Structures of Human Cytochrome P-450 2E1 | Journal of Biological Chemistry | 2008 | 186 |
19 | Formulation Design and Photochemical Studies on Nanocrystal Solid Dispersion of Curcumin with Improved Oral Bioavailability | Journal of Pharmaceutical Sciences | 2010 | 174 |
20 | Hsp90 Inhibitors Identified from a Library of Novobiocin Analogues | Journal of the American Chemical Society | 2005 | 173 |
21 | Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function | Molecular Cell | 2010 | 165 |
22 | Palladium(II)-Catalyzed Direct Arylation of Enaminones Using Organotrifluoroborates | Journal of the American Chemical Society | 2008 | 162 |
23 | A structural model for actin-induced nucleotide release in myosin | Nature Structural and Molecular Biology | 2003 | 159 |
24 | Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes | Chemical Research in Toxicology | 2012 | 159 |
25 | Engineering an Antibiotic to Fight Cancer: Optimization of the Novobiocin Scaffold to Produce Anti-proliferative Agents | Journal of Medicinal Chemistry | 2011 | 157 |
26 | Diels-alder cycloaddition reactions of cyclopropenone ketals | Tetrahedron | 1986 | 152 |
27 | MARK4 Is a Novel Microtubule-associated Proteins/Microtubule Affinity-regulating Kinase That Binds to the Cellular Microtubule Network and to Centrosomes | Journal of Biological Chemistry | 2004 | 151 |
28 | Chemoprotection: A review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituents | Medicinal Research Reviews | 1997 | 150 |
29 | Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships | Journal of Medicinal Chemistry | 2008 | 146 |
30 | Analytical considerations for microdialysis sampling | Advanced Drug Delivery Reviews | 2000 | 145 |
31 | Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity | Biochemical Pharmacology | 2012 | 143 |
32 | A Novel and Expeditious Reduction of Tertiary Amides to Aldehydes Using Cp2Zr(H)Cl | Journal of the American Chemical Society | 2000 | 141 |
33 | Polyhydroxylated C60, fullerenols, as glutamate receptor antagonists and neuroprotective agents | Journal of Neuroscience Research | 2000 | 140 |
34 | The Design, Synthesis, and Evaluation of Coumarin Ring Derivatives of the Novobiocin Scaffold that Exhibit Antiproliferative Activity | Journal of Organic Chemistry | 2008 | 136 |
35 | Epothilone and Paclitaxel: Unexpected Differences in Promoting the Assembly and Stabilization of Yeast Microtubules† | Biochemistry | 2002 | 135 |
36 | Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons | Journal of Neuroscience Research | 2001 | 134 |
37 | Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues | Journal of Medicinal Chemistry | 2010 | 131 |
38 | Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol | Organic Letters | 2015 | 127 |
39 | Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors | Journal of Biological Chemistry | 2013 | 123 |
40 | Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn | European Journal of Pharmacology | 2007 | 121 |
41 | Development of Novobiocin Analogues That Manifest Anti-proliferative Activity against Several Cancer Cell Lines | Journal of Organic Chemistry | 2008 | 121 |
42 | R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse | Biological Psychiatry | 2012 | 121 |
43 | Reactions of Alkyl Azides and Ketones as Mediated by Lewis Acids: Schmidt and Mannich Reactions Using Azide Precursors | Journal of the American Chemical Society | 2000 | 120 |
44 | Human psychopharmacology and dose-effects of salvinorin A, a kappa opioid agonist hallucinogen present in the plant Salvia divinorum | Drug and Alcohol Dependence | 2011 | 120 |
45 | Gambogic Acid, a Natural Product Inhibitor of Hsp90 | Journal of Natural Products | 2011 | 120 |
46 | Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis | Journal of Biological Chemistry | 2013 | 120 |
47 | Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides | PLoS Pathogens | 2012 | 119 |
48 | Evidence That the Fosfomycin Target Cys115 in UDP-N-acetylglucosamine Enolpyruvyl Transferase (MurA) Is Essential for Product Release | Journal of Biological Chemistry | 2005 | 117 |
49 | Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 → Ile and Pro101 → Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coli | Journal of Biological Chemistry | 2009 | 117 |
50 | Peptide Kappa Opioid Receptor Ligands: Potential for Drug Development | AAPS Journal | 2009 | 114 |