| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | PRODRG: a tool for high-throughput crystallography of protein–ligand complexes | Acta Crystallographica Section D: Biological Crystallography | 2004 | 4,230 |
| 3 | Metformin and reduced risk of cancer in diabetic patients | BMJ: British Medical Journal | 2005 | 2,018 |
| 4 | Protein kinases — the major drug targets of the twenty-first century? | Nature Reviews Drug Discovery | 2002 | 1,944 |
| 5 | Cyanobacterial blooms | Nature Reviews Microbiology | 2018 | 1,671 |
| 6 | The Genome of the African Trypanosome Trypanosoma brucei | Science | 2005 | 1,496 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 8 | The renaissance of GSK3 | Nature Reviews Molecular Cell Biology | 2001 | 1,395 |
| 9 | The specificities of protein kinase inhibitors: an update | Biochemical Journal | 2003 | 1,339 |
| 10 | LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1 | EMBO Journal | 2004 | 1,201 |
| 11 | GSK3 takes centre stage more than 20 years after its discovery | Biochemical Journal | 2001 | 1,196 |
| 12 | The genome of the social amoeba Dictyostelium discoideum | Nature | 2005 | 1,179 |
| 13 | Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle | FASEB Journal | 2005 | 968 |
| 14 | Cyanobacterial toxins: risk management for health protection | Toxicology and Applied Pharmacology | 2005 | 964 |
| 15 | GSK3 takes centre stage more than 20 years after its discovery | Biochemical Journal | 2001 | 942 |
| 16 | New Users of Metformin Are at Low Risk of Incident Cancer | Diabetes Care | 2009 | 941 |
| 17 | Global analysis of protein phosphorylation in yeast | Nature | 2005 | 915 |
| 18 | The origins of protein phosphorylation | Nature Cell Biology | 2002 | 904 |
| 19 | Protein phosphatase 1 – targeted in many directions | Journal of Cell Science | 2002 | 800 |
| 20 | Structural basis of PROTAC cooperative recognition for selective protein degradation | Nature Chemical Biology | 2017 | 758 |
| 21 | PDK1, the master regulator of AGC kinase signal transduction | Seminars in Cell and Developmental Biology | 2004 | 715 |
| 22 | LKB1-Dependent Signaling Pathways | Annual Review of Biochemistry | 2006 | 707 |
| 23 | GSK3 inhibitors: development and therapeutic potential | Nature Reviews Drug Discovery | 2004 | 696 |
| 24 | AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs | Trends in Cell Biology | 2016 | 695 |
| 25 | Transcriptional Pulsing of a Developmental Gene | Current Biology | 2006 | 694 |
| 26 | Protein phosphatase 1--targeted in many directions | Journal of Cell Science | 2002 | 682 |
| 27 | AMP-activated protein kinase - development of the energy sensor concept | Journal of Physiology | 2006 | 681 |
| 28 | Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase | EMBO Journal | 2001 | 675 |
| 29 | Evidence that the Ipl1-Sli15 (Aurora Kinase-INCENP) Complex Promotes Chromosome Bi-orientation by Altering Kinetochore-Spindle Pole Connections | Cell | 2002 | 663 |
| 30 | A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation | Molecular Cell | 2001 | 618 |
| 31 | Microbial influence on metal mobility and application for bioremediation | Geoderma | 2004 | 611 |
| 32 | Phosphorus limitation of nitrogen fixation by Trichodesmium in the central Atlantic Ocean | Nature | 2001 | 588 |
| 33 | Signaling and Function of Interleukin-2 in T Lymphocytes | Annual Review of Immunology | 2018 | 539 |
| 34 | Redox regulation of PI 3-kinase signalling via inactivation of PTEN | EMBO Journal | 2003 | 536 |
| 35 | Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis | EMBO Journal | 2005 | 534 |
| 36 | The role of protein phosphorylation in human health and disease. | FEBS Journal | 2001 | 528 |
| 37 | Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation | Nature | 2003 | 526 |
| 38 | A role for the Adenomatous Polyposis Coli protein in chromosome segregation | Nature Cell Biology | 2001 | 510 |
| 39 | The mammalian ULK1 complex and autophagy initiation | Essays in Biochemistry | 2017 | 497 |
| 40 | Kinase drug discovery 20 years after imatinib: progress and future directions | Nature Reviews Drug Discovery | 2021 | 497 |
| 41 | Recruitment to the Nuclear Periphery Can Alter Expression of Genes in Human Cells | PLoS Genetics | 2008 | 494 |
| 42 | Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes | Biochemical Journal | 2004 | 493 |
| 43 | Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase | Biochemical Society Transactions | 2002 | 478 |
| 44 | Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction | EMBO Journal | 2005 | 478 |
| 45 | Emerging roles of pseudokinases | Trends in Cell Biology | 2006 | 475 |
| 46 | Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling | Science | 2004 | 462 |
| 47 | A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation | Molecular Cell | 2009 | 453 |
| 48 | PTEN function: how normal cells control it and tumour cells lose it | Biochemical Journal | 2004 | 448 |
| 49 | The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases | Biochemical Journal | 2005 | 444 |
| 50 | MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 | EMBO Journal | 2003 | 441 |
