| # | Title | Journal | Year | Citations |
|---|
| 1 | Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences | Human Gene Therapy Methods | 2012 | 345 |
| 2 | Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy | Human Gene Therapy Methods | 2013 | 241 |
| 3 | Absolute Determination of Single-Stranded and Self-Complementary Adeno-Associated Viral Vector Genome Titers by Droplet Digital PCR | Human Gene Therapy Methods | 2014 | 132 |
| 4 | Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids | Human Gene Therapy Methods | 2016 | 111 |
| 5 | Analytical Ultracentrifugation as an Approach to Characterize Recombinant Adeno-Associated Viral Vectors | Human Gene Therapy Methods | 2015 | 107 |
| 6 | Dual Adeno-Associated Virus Vectors Result in EfficientIn VitroandIn VivoExpression of an Oversized Gene,MYO7A | Human Gene Therapy Methods | 2014 | 105 |
| 7 | Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells | Human Gene Therapy Methods | 2012 | 102 |
| 8 | Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications | Human Gene Therapy Methods | 2015 | 94 |
| 9 | Long-Term Expression and Safety of Administration of AAVrh.10hCLN2 to the Brain of Rats and Nonhuman Primates for the Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis | Human Gene Therapy Methods | 2012 | 84 |
| 10 | Systemic Errors in Quantitative Polymerase Chain Reaction Titration of Self-Complementary Adeno-Associated Viral Vectors and Improved Alternative Methods | Human Gene Therapy Methods | 2012 | 83 |
| 11 | Determination of Anti-Adeno-Associated Virus Vector Neutralizing Antibody Titer with an In Vitro Reporter System | Human Gene Therapy Methods | 2015 | 82 |
| 12 | Scalable Lentiviral Vector Production Using Stable HEK293SF Producer Cell Lines | Human Gene Therapy Methods | 2017 | 80 |
| 13 | Analysis of Particle Content of Recombinant Adeno-Associated Virus Serotype 8 Vectors by Ion-Exchange Chromatography | Human Gene Therapy Methods | 2012 | 74 |
| 14 | Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiencyin Vitroandin Vivo | Human Gene Therapy Methods | 2013 | 73 |
| 15 | Downstream Processing of Lentiviral Vectors: Releasing Bottlenecks | Human Gene Therapy Methods | 2012 | 71 |
| 16 | Characterization of the Properties of Seven Promoters in the Motor Cortex of Rats and Monkeys After Lentiviral Vector-Mediated Gene Transfer | Human Gene Therapy Methods | 2013 | 71 |
| 17 | Pseudotyped Lentiviral Vectors: One Vector, Many Guises | Human Gene Therapy Methods | 2017 | 68 |
| 18 | A Guide to Approaching Regulatory Considerations for Lentiviral-Mediated Gene Therapies | Human Gene Therapy Methods | 2017 | 68 |
| 19 | Generation and Characterization of Adeno-Associated Virus Producer Cell Lines for Research and Preclinical Vector Production | Human Gene Therapy Methods | 2013 | 63 |
| 20 | Development of a Rapid, Robust, and Universal PicoGreen-Based Method to Titer Adeno-Associated Vectors | Human Gene Therapy Methods | 2015 | 57 |
| 21 | Development of the First World Health Organization Lentiviral Vector Standard: Toward the Production Control and Standardization of Lentivirus-Based Gene Therapy Products | Human Gene Therapy Methods | 2017 | 57 |
| 22 | Manufacture of Third-Generation Lentivirus for Preclinical Use, with Process Development Considerations for Translation to Good Manufacturing Practice | Human Gene Therapy Methods | 2018 | 57 |
| 23 | Manufacture of Gene-Modified Human T-Cells with a Memory Stem/Central Memory Phenotype | Human Gene Therapy Methods | 2014 | 54 |
| 24 | Preexisting Neutralizing Antibodies to Adeno-Associated Virus Capsids in Large Animals Other Than Monkeys May Confound In Vivo Gene Therapy Studies | Human Gene Therapy Methods | 2015 | 52 |
| 25 | Improving miRNA Delivery by Optimizing miRNA Expression Cassettes in Diverse Virus Vectors | Human Gene Therapy Methods | 2017 | 52 |
| 26 | Evaluation of an Optimized Injection System for Retinal Gene Therapy in Human Patients | Human Gene Therapy Methods | 2016 | 49 |
| 27 | Analytical Strategies for Quantification of Adeno-Associated Virus Empty Capsids to Support Process Development | Human Gene Therapy Methods | 2019 | 49 |
| 28 | Transduction of the Central Nervous System After Intracerebroventricular Injection of Adeno-Associated Viral Vectors in Neonatal and Juvenile Mice | Human Gene Therapy Methods | 2013 | 48 |
| 29 | A Rapid Cell Expansion Process for Production of Engineered Autologous CAR-T Cell Therapies | Human Gene Therapy Methods | 2016 | 48 |
| 30 | Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities | Human Gene Therapy Methods | 2017 | 47 |
| 31 | Assessment of Humoral, Innate, and T-Cell Immune Responses to Adeno-Associated Virus Vectors | Human Gene Therapy Methods | 2018 | 46 |
| 32 | CAR T-Cell Therapy: Progress and Prospects | Human Gene Therapy Methods | 2017 | 45 |
| 33 | Optimization of Electroporation-Enhanced Intradermal Delivery of DNA Vaccine Using a Minimally Invasive Surface Device | Human Gene Therapy Methods | 2012 | 44 |
| 34 | Skin Transfection Patterns and Expression Kinetics of Electroporation-Enhanced Plasmid Delivery Using the CELLECTRA-3P, a Portable Next-Generation Dermal Electroporation Device | Human Gene Therapy Methods | 2015 | 44 |
| 35 | Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins | Human Gene Therapy Methods | 2017 | 44 |
| 36 | Protocol for Efficient Generation and Characterization of Adeno-Associated Viral Vectors | Human Gene Therapy Methods | 2017 | 44 |
| 37 | Bioinformatic Clonality Analysis of Next-Generation Sequencing-Derived Viral Vector Integration Sites | Human Gene Therapy Methods | 2012 | 43 |
| 38 | Targeted Modifications in Adeno-Associated Virus Serotype 8 Capsid Improves Its Hepatic Gene Transfer Efficiency In Vivo | Human Gene Therapy Methods | 2013 | 43 |
| 39 | Development of Automated Separation, Expansion, and Quality Control Protocols for Clinical-Scale Manufacturing of Primary Human NK Cells and Alpharetroviral Chimeric Antigen Receptor Engineering | Human Gene Therapy Methods | 2019 | 43 |
| 40 | Systematic Comparison and Validation of Quantitative Real-Time PCR Methods for the Quantitation of Adeno-Associated Viral Products | Human Gene Therapy Methods | 2015 | 42 |
| 41 | Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs | Human Gene Therapy Methods | 2019 | 42 |
| 42 | Retrograde Gene Delivery to Hypoglossal Motoneurons Using Adeno-Associated Virus Serotype 9 | Human Gene Therapy Methods | 2012 | 39 |
| 43 | Transduction of Human CD34+Repopulating Cells with a Self-Inactivating Lentiviral Vector for SCID-X1 Produced at Clinical Scale by a Stable Cell Line | Human Gene Therapy Methods | 2012 | 39 |
| 44 | AAV2/8 Vectors Purified from Culture Medium with a Simple and Rapid Protocol Transduce Murine Liver, Muscle, and Retina Efficiently | Human Gene Therapy Methods | 2013 | 39 |
| 45 | Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield | Human Gene Therapy Methods | 2016 | 39 |
| 46 | Two-Dimensional Droplet Digital PCR as a Tool for Titration and Integrity Evaluation of Recombinant Adeno-Associated Viral Vectors | Human Gene Therapy Methods | 2019 | 39 |
| 47 | Specific Targeting of Human Interleukin (IL)-13 Receptor α2-Positive Cells with Lentiviral Vectors Displaying IL-13 | Human Gene Therapy Methods | 2012 | 38 |
| 48 | Exon Skipping Quantification by Quantitative Reverse-Transcription Polymerase Chain Reaction in Duchenne Muscular Dystrophy Patients Treated with the Antisense Oligomer Eteplirsen | Human Gene Therapy Methods | 2012 | 38 |
| 49 | Potential Limitations of the NSG Humanized Mouse as a Model System to Optimize Engineered Human T cell Therapy for Cancer | Human Gene Therapy Methods | 2013 | 38 |
| 50 | Sonoporation Increases Therapeutic Efficacy of Inducible and Constitutive BMP2/7 In Vivo Gene Delivery | Human Gene Therapy Methods | 2014 | 38 |
