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Top Articles

#TitleJournalYearCitations
1A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug DatabasesACS Combinatorial Science19992,037
2Increasing Rates of Reaction:  Microwave-Assisted Organic Synthesis for Combinatorial ChemistryACS Combinatorial Science2002348
3Chemography:  The Art of Navigating in Chemical SpaceACS Combinatorial Science2001320
4Comprehensive Survey of Combinatorial Library Synthesis:  1998ACS Combinatorial Science1999284
5Recent Advances in the Preparation of Heterocycles on Solid Support: A Review of the LiteratureACS Combinatorial Science2000279
6Scaffold Architecture and Pharmacophoric Properties of Natural Products and Trade Drugs:  Application in the Design of Natural Product-Based Combinatorial LibrariesACS Combinatorial Science2001270
7Efficient One-Pot Synthesis of Spirooxindole Derivatives Catalyzed byl-Proline in Aqueous MediumACS Combinatorial Science2010259
8ChemMatrix, a Poly(ethylene glycol)-Based Support for the Solid-Phase Synthesis of Complex PeptidesACS Combinatorial Science2006241
9Automated Library Generation Using Sequential Microwave-Assisted Chemistry. Application toward the Biginelli Multicomponent CondensationACS Combinatorial Science2001233
10Comprehensive Survey of Combinatorial Library Synthesis:  2005ACS Combinatorial Science2006219
11Application of Combinatorial Chemistry Science on Modern Drug DiscoveryACS Combinatorial Science2008206
12Combinatorial Lead Optimization of [1,2]-Diamines Based on Ethambutol as Potential Antituberculosis Preclinical CandidatesACS Combinatorial Science2003205
13Comprehensive Survey of Combinatorial Library Synthesis:  2000ACS Combinatorial Science2001194
14Comprehensive Survey of Combinatorial Library Synthesis:  1999ACS Combinatorial Science2000183
15Solution- and Solid-Phase Strategies for the Design, Synthesis, and Screening of Libraries Based on Natural Product Templates:  A Comprehensive SurveyACS Combinatorial Science2001182
16In Situ Generation of Carbon Monoxide from Solid Molybdenum Hexacarbonyl. A Convenient and Fast Route to Palladium-Catalyzed Carbonylation ReactionsACS Combinatorial Science2002171
17Beyond Mere Diversity:  Tailoring Combinatorial Libraries for Drug DiscoveryACS Combinatorial Science1999170
18Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones by Three-Component Coupling of Isatoic Anhydride, Amines, and Aldehydes Catalyzed by Magnetic Fe3O4 Nanoparticles in WaterACS Combinatorial Science2010170
19Combinatorial Electrochemical Screening of Fuel Cell ElectrocatalystsACS Combinatorial Science2004164
20Continuous-Flow High Pressure Hydrogenation Reactor for Optimization and High-Throughput SynthesisACS Combinatorial Science2006159
21Diversity Oriented Synthesis of Benzoxanthene and Benzochromene Libraries via One-Pot, Three-Component Reactions and Their Anti-proliferative ActivityACS Combinatorial Science2010153
22Solid-Phase Organic Synthesis:  A Critical Understanding of the Resin†ACS Combinatorial Science2000152
23Combinatorial Library of Peptidotriazoles:  Identification of [1,2,3]-Triazole Inhibitors against a RecombinantLeishmaniamexicanaCysteine ProteaseACS Combinatorial Science2004147
24Automated Electrochemical Synthesis and Photoelectrochemical Characterization of Zn1-xCoxO Thin Films for Solar Hydrogen ProductionACS Combinatorial Science2005147
25Efficient One-Pot Synthesis of Novel Spirooxindole Derivatives via Three-Component Reaction in Aqueous MediumACS Combinatorial Science2010142
26Catalyst-Free One-Pot Four Component Synthesis of Polysubstituted Imidazoles in Neutral Ionic Liquid 1-Butyl-3-methylimidazolium BromideACS Combinatorial Science2010141
27Combinatorial Approach to the Development of a Single Mass YVO4:Bi3+,Eu3+ Phosphor with Red and Green Dual Colors for High Color Rendering White Light-Emitting DiodesACS Combinatorial Science2010140
28High-Throughput Screening Using Porous Photoelectrode for the Development of Visible-Light-Responsive SemiconductorsACS Combinatorial Science2007136
29Comprehensive Survey of Combinatorial Library Synthesis:  2003ACS Combinatorial Science2004133
30meso-Tetra(pentafluorophenyl)porphyrin as an Efficient Platform for Combinatorial Synthesis and the Selection of New Photodynamic Therapeutics using a Cancer Cell LineACS Combinatorial Science2007133
31Combining Biginelli Multicomponent and Click Chemistry:  Generation of 6-(1,2,3-Triazol-1-yl)-Dihydropyrimidone LibrariesACS Combinatorial Science2004132
32Solid-Phase Synthesis of Biologically Active Benzoannelated Nitrogen Heterocycles: An UpdateACS Combinatorial Science2009131
33Novel One-Pot, Three-Component Synthesis of Spiro[Indoline-pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]trione LibraryACS Combinatorial Science2009124
34Comprehensive Survey of Combinatorial Library Synthesis:  2001ACS Combinatorial Science2002123
35Comprehensive Survey of Combinatorial Library Synthesis:  2002ACS Combinatorial Science2003122
36Synthesis of 2-Aminobenzothiazole via Copper(I)-Catalyzed Tandem Reaction of 2-Iodobenzenamine with IsothiocyanateACS Combinatorial Science2009121
37Microwave-Assisted Three-Component Synthesis of 7-Aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and Their Selective ReductionACS Combinatorial Science2006114
38Spatially Addressed Synthesis of Amino- and Amino-Oxy-Substituted 1,3,5-Triazine Arrays on Polymeric MembranesACS Combinatorial Science2000113
39Combinatorial Electrochemical Synthesis and Characterization of Tungsten-Based Mixed-Metal OxidesACS Combinatorial Science2002113
40Parallel Personal Comments on “Classical” Papers in Combinatorial ChemistryACS Combinatorial Science1999110
41An Alkylsilyl-Tethered, High-Capacity Solid Support Amenable to Diversity-Oriented Synthesis for One-Bead, One-Stock Solution Chemical GeneticsACS Combinatorial Science2001110
42Multicomponent Reactions to Form Heterocycles by Microwave-Assisted Continuous Flow Organic SynthesisACS Combinatorial Science2007110
43Microwave-Assisted Combinatorial Synthesis of Hexa-Substituted 1,4-Dihydropyridines Scaffolds Using One-Pot Two-Step Multicomponent Reaction followed by a S-AlkylationACS Combinatorial Science2008110
44New Convenient Four-Component Synthesis of 6-Amino-2,4-dihydropyrano[2,3-c]pyrazol-5-carbonitriles and One-Pot Synthesis of 6′-Aminospiro[(3H)-indol-3,4′-pyrano[2,3-c]pyrazol]-(1H)-2-on-5′-carbonitrilesACS Combinatorial Science2009110
45Novel One-Pot Three- and Pseudo-Five-Component Reactions: Synthesis of Functionalized Benzo[g]- and Dihydropyrano[2,3-g]chromene DerivativesACS Combinatorial Science2009109
46Strategies for the Use of Mixture-Based Synthetic Combinatorial Libraries: Scaffold Ranking, Direct Testing In Vivo, and Enhanced Deconvolution by Computational MethodsACS Combinatorial Science2008108
47Concise and Versatile Multicomponent Synthesis of Multisubstituted Polyfunctional DihydropyrrolesACS Combinatorial Science2009105
48Sulfonic Acid Functionalized Ionic Liquid in Combinatorial Approach, a Recyclable and Water Tolerant-Acidic Catalyst for One-Pot Friedlander Quinoline SynthesisACS Combinatorial Science2010105
49The Recent Impact of Solid-Phase Synthesis on Medicinally Relevant Benzoannelated Oxygen HeterocyclesACS Combinatorial Science2005103
50Efficient Synthesis of Spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones by a One-Pot and Three-Component ReactionACS Combinatorial Science2009103