| # | Title | Journal | Year | Citations |
|---|
| 1 | The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors | Nature Immunology | 2010 | 7,320 |
| 2 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells | Nature Immunology | 2003 | 6,653 |
| 3 | Cancer immunoediting: from immunosurveillance to tumor escape | Nature Immunology | 2002 | 4,290 |
| 4 | Toll-like receptors: critical proteins linking innate and acquired immunity | Nature Immunology | 2001 | 4,209 |
| 5 | Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages | Nature Immunology | 2005 | 4,106 |
| 6 | A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 | Nature Immunology | 2005 | 3,869 |
| 7 | Toll-like receptor control of the adaptive immune responses | Nature Immunology | 2004 | 3,662 |
| 8 | The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses | Nature Immunology | 2004 | 3,433 |
| 9 | T cell exhaustion | Nature Immunology | 2011 | 3,178 |
| 10 | Innate and adaptive immune cells in the tumor microenvironment | Nature Immunology | 2013 | 3,109 |
| 11 | Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm | Nature Immunology | 2010 | 3,073 |
| 12 | Functions of natural killer cells | Nature Immunology | 2008 | 3,070 |
| 13 | Complement: a key system for immune surveillance and homeostasis | Nature Immunology | 2010 | 2,990 |
| 14 | Nitric oxide and the immune response | Nature Immunology | 2001 | 2,838 |
| 15 | NF-κB at the crossroads of life and death | Nature Immunology | 2002 | 2,611 |
| 16 | Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization | Nature Immunology | 2008 | 2,568 |
| 17 | An essential role for Scurfin in CD4+CD25+ T regulatory cells | Nature Immunology | 2003 | 2,525 |
| 18 | PD-L2 is a second ligand for PD-1 and inhibits T cell activation | Nature Immunology | 2001 | 2,504 |
| 19 | Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome | Nature Immunology | 2011 | 2,447 |
| 20 | Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self | Nature Immunology | 2005 | 2,417 |
| 21 | IKKε and TBK1 are essential components of the IRF3 signaling pathway | Nature Immunology | 2003 | 2,361 |
| 22 | Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage | Nature Immunology | 2019 | 2,330 |
| 23 | Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway | Nature Immunology | 2002 | 2,290 |
| 24 | IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction | Nature Immunology | 2005 | 2,254 |
| 25 | Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria | Nature Immunology | 2001 | 2,239 |
| 26 | Thioredoxin-interacting protein links oxidative stress to inflammasome activation | Nature Immunology | 2010 | 2,163 |
| 27 | Resolution of inflammation: the beginning programs the end | Nature Immunology | 2005 | 2,060 |
| 28 | The NALP3 inflammasome is involved in the innate immune response to amyloid-β | Nature Immunology | 2008 | 2,047 |
| 29 | IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways | Nature Immunology | 2007 | 1,873 |
| 30 | Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP | Nature Immunology | 2002 | 1,847 |
| 31 | The immune system in atherosclerosis | Nature Immunology | 2011 | 1,825 |
| 32 | IL-6 as a keystone cytokine in health and disease | Nature Immunology | 2015 | 1,825 |
| 33 | Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells | Nature Immunology | 2010 | 1,811 |
| 34 | Development, cytokine profile and function of human interleukin 17–producing helper T cells | Nature Immunology | 2007 | 1,795 |
| 35 | Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection | Nature Immunology | 2009 | 1,754 |
| 36 | Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages | Nature Immunology | 2012 | 1,731 |
| 37 | The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity | Nature Immunology | 2005 | 1,697 |
| 38 | IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex | Nature Immunology | 2003 | 1,670 |
| 39 | Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells | Nature Immunology | 2007 | 1,670 |
| 40 | Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells | Nature Immunology | 2007 | 1,660 |
| 41 | Innate immune recognition of viral infection | Nature Immunology | 2006 | 1,654 |
| 42 | Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule | Nature Immunology | 2000 | 1,626 |
| 43 | Lineage relationship and protective immunity of memory CD8 T cell subsets | Nature Immunology | 2003 | 1,621 |
| 44 | Tissue-resident macrophages | Nature Immunology | 2013 | 1,621 |
| 45 | Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells | Nature Immunology | 2003 | 1,605 |
| 46 | A function for interleukin 2 in Foxp3-expressing regulatory T cells | Nature Immunology | 2005 | 1,577 |
| 47 | The Immunological Genome Project: networks of gene expression in immune cells | Nature Immunology | 2008 | 1,576 |
| 48 | The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis | Nature Immunology | 2009 | 1,568 |
| 49 | Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance | Nature Immunology | 2002 | 1,566 |
| 50 | Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice | Nature Immunology | 2007 | 1,523 |
