| # | Title | Journal | Year | Citations |
|---|
| 1 | Practical methods for incorporating summary time-to-event data into meta-analysis | Trials | 2007 | 4,941 |
| 2 | Developing core outcome sets for clinical trials: issues to consider | Trials | 2012 | 1,226 |
| 3 | CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials | Trials | 2010 | 1,129 |
| 4 | The COMET Handbook: version 1.0 | Trials | 2017 | 1,128 |
| 5 | What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies | Trials | 2006 | 712 |
| 6 | Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II | Trials | 2009 | 672 |
| 7 | How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline | Trials | 2016 | 659 |
| 8 | A literature review on the representativeness of randomized controlled trial samples and implications for the external validity of trial results | Trials | 2015 | 563 |
| 9 | OMERACT: An international initiative to improve outcome measurement in rheumatology | Trials | 2007 | 420 |
| 10 | Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study | Trials | 2014 | 407 |
| 11 | Theory of Change: a theory-driven approach to enhance the Medical Research Council's framework for complex interventions | Trials | 2014 | 392 |
| 12 | Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal | Trials | 2010 | 391 |
| 13 | Standardising outcomes for clinical trials and systematic reviews | Trials | 2007 | 373 |
| 14 | Making trials matter: pragmatic and explanatory trials and the problem of applicability | Trials | 2009 | 361 |
| 15 | Reporting bias in medical research - a narrative review | Trials | 2010 | 361 |
| 16 | Process evaluations for cluster-randomised trials of complex interventions: a proposed framework for design and reporting | Trials | 2013 | 358 |
| 17 | Through the looking glass: understanding non-inferiority | Trials | 2011 | 312 |
| 18 | A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies | Trials | 2013 | 295 |
| 19 | The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies | Trials | 2014 | 291 |
| 20 | Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities | Trials | 2014 | 279 |
| 21 | MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: study protocol for a randomized controlled trial | Trials | 2014 | 277 |
| 22 | The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind placebo controlled trial | Trials | 2010 | 247 |
| 23 | The challenges faced in the design, conduct and analysis of surgical randomised controlled trials | Trials | 2009 | 241 |
| 24 | Design, analysis, and presentation of crossover trials | Trials | 2009 | 237 |
| 25 | Core Outcome Measures in Effectiveness Trials (COMET) initiative: protocol for an international Delphi study to achieve consensus on how to select outcome measurement instruments for outcomes included in a ‘core outcome set’ | Trials | 2014 | 237 |
| 26 | Why clinical trial outcomes fail to translate into benefits for patients | Trials | 2017 | 235 |
| 27 | Blockchain technology for improving clinical research quality | Trials | 2017 | 232 |
| 28 | Systematic review of basket trials, umbrella trials, and platform trials: a landscape analysis of master protocols | Trials | 2019 | 232 |
| 29 | Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial | Trials | 2018 | 221 |
| 30 | Reasons for participating in randomised controlled trials: conditional altruism and considerations for self | Trials | 2010 | 219 |
| 31 | Criteria for Reporting the Development and Evaluation of Complex Interventions in healthcare: revised guideline (CReDECI 2) | Trials | 2015 | 217 |
| 32 | Endorsement of the CONSORT Statement by high impact factor medical journals: a survey of journal editors and journal 'Instructions to Authors' | Trials | 2008 | 206 |
| 33 | Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac – PROFISCOV: A structured summary of a study protocol for a randomised controlled trial | Trials | 2020 | 205 |
| 34 | Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial | Trials | 2013 | 198 |
| 35 | Adaptive trial designs: a review of barriers and opportunities | Trials | 2012 | 195 |
| 36 | Randomized trials published in some Chinese journals: how many are randomized? | Trials | 2009 | 194 |
| 37 | Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials | Trials | 2014 | 194 |
| 38 | Intervention description is not enough: evidence from an in-depth multiple case study on the untold role and impact of context in randomised controlled trials of seven complex interventions | Trials | 2012 | 187 |
| 39 | HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial | Trials | 2014 | 185 |
| 40 | Reporting randomised trials of social and psychological interventions: the CONSORT-SPI 2018 Extension | Trials | 2018 | 180 |
| 41 | CONSORT-SPI 2018 Explanation and Elaboration: guidance for reporting social and psychological intervention trials | Trials | 2018 | 179 |
| 42 | Designing a stepped wedge trial: three main designs, carry-over effects and randomisation approaches | Trials | 2015 | 176 |
| 43 | Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)? | Trials | 2018 | 168 |
| 44 | Allocation techniques for balance at baseline in cluster randomized trials: a methodological review | Trials | 2012 | 165 |
| 45 | The ROAM/EORTC-1308 trial: Radiation versus Observation following surgical resection of Atypical Meningioma: study protocol for a randomised controlled trial | Trials | 2015 | 165 |
| 46 | International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol | Trials | 2011 | 163 |
| 47 | Optimising recruitment and informed consent in randomised controlled trials: the development and implementation of the Quintet Recruitment Intervention (QRI) | Trials | 2016 | 162 |
| 48 | Comparisons against baseline within randomised groups are often used and can be highly misleading | Trials | 2011 | 159 |
| 49 | MOMENT – Management of Otitis Media with Effusion in Cleft Palate: protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey | Trials | 2013 | 158 |
| 50 | Single blind randomized Phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized controlled trial | Trials | 2011 | 156 |
