| # | Title | Journal | Year | Citations |
|---|
| 1 | Role of Insulin Resistance in Human Disease | Diabetes | 1988 | 10,677 |
| 2 | Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance | Diabetes | 1979 | 5,711 |
| 3 | Metabolic Endotoxemia Initiates Obesity and Insulin Resistance | Diabetes | 2007 | 4,964 |
| 4 | Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice | Diabetes | 2008 | 3,897 |
| 5 | Banting lecture 1988. Role of insulin resistance in human disease | Diabetes | 1988 | 3,748 |
| 6 | -Cell Deficit and Increased -Cell Apoptosis in Humans With Type 2 Diabetes | Diabetes | 2003 | 3,615 |
| 7 | Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas | Diabetes | 1967 | 2,925 |
| 8 | Role of Oxidative Stress in Development of Complications in Diabetes | Diabetes | 1991 | 2,551 |
| 9 | A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans | Diabetes | 2001 | 2,550 |
| 10 | The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM | Diabetes | 1988 | 2,466 |
| 11 | Reviewers of Manuscripts | Diabetes | 1991 | 2,465 |
| 12 | Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats | Diabetes | 1963 | 2,403 |
| 13 | From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus | Diabetes | 2009 | 2,251 |
| 14 | Role of oxidative stress in diabetic complications: a new perspective on an old paradigm | Diabetes | 1999 | 2,190 |
| 15 | Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome | Diabetes | 2001 | 2,100 |
| 16 | Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes | Diabetes | 2002 | 1,975 |
| 17 | U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease | Diabetes | 1995 | 1,798 |
| 18 | Circulating Ghrelin Levels Are Decreased in Human Obesity | Diabetes | 2001 | 1,786 |
| 19 | Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome | Diabetes | 1989 | 1,697 |
| 20 | Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study | Diabetes | 1974 | 1,666 |
| 21 | PPAR-gamma: adipogenic regulator and thiazolidinedione receptor | Diabetes | 1998 | 1,659 |
| 22 | High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans | Diabetes | 2009 | 1,650 |
| 23 | The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization | Diabetes | 1981 | 1,647 |
| 24 | Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2 | Diabetes | 2012 | 1,644 |
| 25 | Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice | Diabetes | 2009 | 1,630 |
| 26 | PPAR Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein | Diabetes | 2001 | 1,591 |
| 27 | Five-Year Follow-Up After Clinical Islet Transplantation | Diabetes | 2005 | 1,489 |
| 28 | Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM | Diabetes | 1997 | 1,402 |
| 29 | High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells | Diabetes | 2000 | 1,379 |
| 30 | Are Oxidative Stress-Activated Signaling Pathways Mediators of Insulin Resistance and -Cell Dysfunction? | Diabetes | 2003 | 1,351 |
| 31 | Banting Lecture 1980: of Pregnancy and Progeny | Diabetes | 1980 | 1,338 |
| 32 | NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older | Diabetes | 2003 | 1,332 |
| 33 | Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function | Diabetes | 1993 | 1,302 |
| 34 | Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease | Diabetes | 2007 | 1,301 |
| 35 | Preservation of Pancreatic -Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women | Diabetes | 2002 | 1,298 |
| 36 | Mechanisms of Pancreatic -Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities | Diabetes | 2005 | 1,296 |
| 37 | Pathologic Anatomy of the Pancreas in Juvenile Diabetes Mellitus | Diabetes | 1965 | 1,295 |
| 38 | Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study | Diabetes | 2003 | 1,282 |
| 39 | Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance | Diabetes | 1992 | 1,263 |
| 40 | Automated Method for Isolation of Human Pancreatic Islets | Diabetes | 1988 | 1,236 |
| 41 | Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and I B- | Diabetes | 2002 | 1,216 |
| 42 | Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man | Diabetes | 1981 | 1,199 |
| 43 | Protein kinase C activation and the development of diabetic complications | Diabetes | 1998 | 1,197 |
| 44 | The Relationship of Glycemic Exposure (HbA1c) to the Risk of Development and Progression of Retinopathy in the Diabetes Control and Complications Trial | Diabetes | 1995 | 1,184 |
| 45 | Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats | Diabetes | 1999 | 1,161 |
| 46 | Role of oxidative stress in development of complications in diabetes | Diabetes | 1991 | 1,139 |
| 47 | Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X) | Diabetes | 1992 | 1,102 |
| 48 | Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships | Diabetes | 2000 | 1,099 |
| 49 | Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies: The Honolulu-Asia Aging Study | Diabetes | 2002 | 1,097 |
| 50 | Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans | Diabetes | 2007 | 1,094 |
