| # | Title | Journal | Year | Citations |
|---|
| 1 | Application of the pople-santry-segal CNDO method to the cyclopropylcarbinyl and cyclobutyl cation and to bicyclobutane | Tetrahedron | 1968 | 4,057 |
| 2 | Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges | Tetrahedron | 1980 | 3,706 |
| 3 | Microwave assisted organic synthesis—a review | Tetrahedron | 2001 | 2,496 |
| 4 | Recent advances in olefin metathesis and its application in organic synthesis | Tetrahedron | 1998 | 2,114 |
| 5 | The relationship between proton-proton NMR coupling constants and substituent electronegativities—I | Tetrahedron | 1980 | 2,082 |
| 6 | Tetrahedron report number 163 | Tetrahedron | 1984 | 1,941 |
| 7 | Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis | Tetrahedron | 2002 | 1,605 |
| 8 | Amide bond formation and peptide coupling | Tetrahedron | 2005 | 1,493 |
| 9 | Microwave assisted organic reactions | Tetrahedron | 1995 | 1,385 |
| 10 | A detailed examination of boronic acid–diol complexation | Tetrahedron | 2002 | 1,286 |
| 11 | A tentative rationalization of microwave effects in organic synthesis according to the reaction medium, and mechanistic considerations | Tetrahedron | 2001 | 1,255 |
| 12 | Tetrahedron report number 221 | Tetrahedron | 1987 | 1,209 |
| 13 | Olefin metathesis | Tetrahedron | 2004 | 1,184 |
| 14 | Oxidation of alcohols by “activated” dimethyl sulfoxide. a preparative, steric and mechanistic study | Tetrahedron | 1978 | 1,169 |
| 15 | 100 years of the biginelli dihydropyrimidine synthesis | Tetrahedron | 1993 | 1,158 |
| 16 | Proline-catalyzed asymmetric reactions | Tetrahedron | 2002 | 1,118 |
| 17 | Oxidation of α,β-un saturated aldehydes | Tetrahedron | 1981 | 1,101 |
| 18 | Luminescent sensors and switches in the early 21st century | Tetrahedron | 2005 | 1,074 |
| 19 | Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support | Tetrahedron | 1992 | 1,064 |
| 20 | LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition | Tetrahedron | 1998 | 960 |
| 21 | Catalytic cross-coupling reactions in biaryl synthesis | Tetrahedron | 1998 | 944 |
| 22 | Porphyrin-based photosensitizers for use in photodynamic therapy | Tetrahedron | 1998 | 927 |
| 23 | Carbon-13 NMR studies of flavonoids—III | Tetrahedron | 1978 | 915 |
| 24 | Imidazolylidenes, imidazolinylidenes and imidazolidines | Tetrahedron | 1999 | 904 |
| 25 | Transition metal catalyzed oxidative functionalization of carbon–hydrogen bonds | Tetrahedron | 2006 | 861 |
| 26 | Room temperature synthesis of metal-organic frameworks: MOF-5, MOF-74, MOF-177, MOF-199, and IRMOF-0 | Tetrahedron | 2008 | 853 |
| 27 | The Baylis-Hillman reaction: A novel carbon-carbon bond forming reaction | Tetrahedron | 1996 | 843 |
| 28 | The Synthesis of Vicinal Amino Alcohols | Tetrahedron | 2000 | 838 |
| 29 | Quantitative characterization of the global electrophilicity power of common diene/dienophile pairs in Diels–Alder reactions | Tetrahedron | 2002 | 832 |
| 30 | Nucleophilic ring opening of aziridines | Tetrahedron | 2004 | 820 |
| 31 | Recent developments in the stereoselective synthesis of α-aminoacids | Tetrahedron | 1994 | 811 |
| 32 | Enantioselective Conjugate Additions | Tetrahedron | 2000 | 798 |
| 33 | Determination of Association Constants (Ka) from Solution NMR Data | Tetrahedron | 2000 | 794 |
| 34 | Recent advances in the staudinger reaction | Tetrahedron | 1992 | 736 |
| 35 | Recent studies on the reactions of α-diazocarbonyl compounds | Tetrahedron | 2008 | 728 |
| 36 | Tetrahedron report number 203 | Tetrahedron | 1986 | 718 |
| 37 | The Henry reaction: recent examples | Tetrahedron | 2001 | 703 |
| 38 | Marine cyanobacteria—a prolific source of natural products | Tetrahedron | 2001 | 703 |
| 39 | Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach | Tetrahedron | 1992 | 693 |
| 40 | Stereochemistry of reaction paths at carbonyl centres | Tetrahedron | 1974 | 689 |
| 41 | Chemical and biochemical transformations in ionic liquids | Tetrahedron | 2005 | 687 |
| 42 | Regio- and stereo-selectivity of alkenyl radical ring closure: A theoretical study | Tetrahedron | 1985 | 686 |
| 43 | Regio-selectivity and stereo-selectivity in radical reactions | Tetrahedron | 1981 | 678 |
| 44 | Recent progress in the synthesis of 1,2,3,4,-tetrahydroquinolines | Tetrahedron | 1996 | 677 |
| 45 | Recent development of peptide coupling reagents in organic synthesis | Tetrahedron | 2004 | 677 |
| 46 | Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products | Tetrahedron | 1987 | 676 |
| 47 | Synthetic potential of the tertiary-amine-catalysed reaction of activated vinyl carbanions with aldehydes | Tetrahedron | 1988 | 674 |
| 48 | How good is fluorine as a hydrogen bond acceptor? | Tetrahedron | 1996 | 674 |
| 49 | De novo synthesis of substituted pyridines | Tetrahedron | 2004 | 666 |
| 50 | Combinatorial synthesis — the design of compound libraries and their application to drug discovery | Tetrahedron | 1995 | 658 |
