# | Title | Journal | Year | Citations |
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1 | Intracellular Toll-like Receptors | Immunity | 2010 | 1,173 |
2 | TLRs and innate immunity | Blood | 2009 | 715 |
3 | The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency | Science | 2008 | 517 |
4 | Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism | Science | 2009 | 443 |
5 | Toll-like receptors | Current Biology | 2011 | 416 |
6 | Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery | Science | 2011 | 308 |
7 | Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing | Journal of Experimental Medicine | 2009 | 285 |
8 | Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases | Immunological Reviews | 2009 | 231 |
9 | Plant and Animal Sensors of Conserved Microbial Signatures | Science | 2010 | 224 |
10 | Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families | PLoS Genetics | 2013 | 192 |
11 | Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice | Hepatology | 2013 | 187 |
12 | Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 183 |
13 | Genetic analysis of resistance to viral infection | Nature Reviews Immunology | 2007 | 172 |
14 | A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest | Nature Structural and Molecular Biology | 2012 | 147 |
15 | Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors | Immunity | 2007 | 138 |
16 | Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 136 |
17 | MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 134 |
18 | Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 123 |
19 | NK cell–mediated killing of target cells triggers robust antigen-specific T cell–mediated and humoral responses | Blood | 2009 | 123 |
20 | TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 115 |
21 | Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 114 |
22 | Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 109 |
23 | The BTB-ZF transcription factors | Cell Cycle | 2012 | 106 |
24 | Sensors of the innate immune system: their mode of action | Nature Reviews Rheumatology | 2009 | 105 |
25 | A forward genetic screen reveals roles for Nfkbid , Zeb1 , and Ruvbl2 in humoral immunity | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 104 |
26 | Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery | PLoS Biology | 2009 | 92 |
27 | The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow | Nature Immunology | 2011 | 85 |
28 | Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2 | PLoS ONE | 2009 | 85 |
29 | iRhom2 is required for the secretion of mouse TNFα | Blood | 2012 | 84 |
30 | The Rab27a Effectors JFC1/Slp1 and Munc13‐4 Regulate Exocytosis of Neutrophil Granules | Traffic | 2008 | 79 |
31 | An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence | Nature Immunology | 2010 | 78 |
32 | Sensors of the innate immune system: their link to rheumatic diseases | Nature Reviews Rheumatology | 2010 | 76 |
33 | Viral RNA Induces Type I Interferon-Dependent Cytokine Release and Cell Death in Mesangial Cells via Melanoma-Differentiation-Associated Gene-5 | American Journal of Pathology | 2009 | 70 |
34 | An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response | Cell Death and Differentiation | 2009 | 68 |
35 | Dual Functions of Rift Valley Fever Virus NSs Protein: Inhibition of Host mRNA Transcription and Post‐transcriptional Downregulation of Protein Kinase PKR | Annals of the New York Academy of Sciences | 2009 | 65 |
36 | A catechol- O -methyltransferase that is essential for auditory function in mice and humans | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 62 |
37 | ATP-sensitive potassium channels mediate survival during infection in mammals and insects | Nature Genetics | 2007 | 61 |
38 | Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient Mice | Journal of Immunology | 2010 | 60 |
39 | Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice | Blood | 2011 | 60 |
40 | X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 57 |
41 | ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 56 |
42 | Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation Analysis | Genetics | 2011 | 56 |
43 | Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 54 |
44 | ENU-induced phenovariance in mice: inferences from 587 mutations | BMC Research Notes | 2012 | 46 |
45 | Precis on forward genetics in mice | Nature Immunology | 2007 | 42 |
46 | Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 38 |
47 | Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection | PLoS Pathogens | 2012 | 38 |
48 | RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling Events | Journal of Immunology | 2014 | 38 |
49 | ZBTB1 is a determinant of lymphoid development | Journal of Experimental Medicine | 2012 | 35 |
50 | LGP2: Positive about viral sensing | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 33 |