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Top Articles

#TitleJournalYearCitations
1Intracellular Toll-like ReceptorsImmunity20101,173
2TLRs and innate immunityBlood2009715
3The Serine Protease TMPRSS6 Is Required to Sense Iron DeficiencyScience2008517
4Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota MutualismScience2009443
5Toll-like receptorsCurrent Biology2011416
6Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryScience2011308
7Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensingJournal of Experimental Medicine2009285
8Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseasesImmunological Reviews2009231
9Plant and Animal Sensors of Conserved Microbial SignaturesScience2010224
10Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen FamiliesPLoS Genetics2013192
11Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in miceHepatology2013187
12Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cellsProceedings of the National Academy of Sciences of the United States of America2010183
13Genetic analysis of resistance to viral infectionNature Reviews Immunology2007172
14A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrestNature Structural and Molecular Biology2012147
15Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like ReceptorsImmunity2007138
16Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupusProceedings of the National Academy of Sciences of the United States of America2009136
17MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligandsProceedings of the National Academy of Sciences of the United States of America2010134
18Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein responseProceedings of the National Academy of Sciences of the United States of America2009123
19NK cell–mediated killing of target cells triggers robust antigen-specific T cell–mediated and humoral responsesBlood2009123
20TLR4/MD-2 activation by a synthetic agonist with no similarity to LPSProceedings of the National Academy of Sciences of the United States of America2016115
21Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupusProceedings of the National Academy of Sciences of the United States of America2013114
22Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial triggerProceedings of the National Academy of Sciences of the United States of America2008109
23The BTB-ZF transcription factorsCell Cycle2012106
24Sensors of the innate immune system: their mode of actionNature Reviews Rheumatology2009105
25A forward genetic screen reveals roles for Nfkbid , Zeb1 , and Ruvbl2 in humoral immunityProceedings of the National Academy of Sciences of the United States of America2012104
26Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the PeripheryPLoS Biology200992
27The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrowNature Immunology201185
28Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2PLoS ONE200985
29iRhom2 is required for the secretion of mouse TNFαBlood201284
30The Rab27a Effectors JFC1/Slp1 and Munc13‐4 Regulate Exocytosis of Neutrophil GranulesTraffic200879
31An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescenceNature Immunology201078
32Sensors of the innate immune system: their link to rheumatic diseasesNature Reviews Rheumatology201076
33Viral RNA Induces Type I Interferon-Dependent Cytokine Release and Cell Death in Mesangial Cells via Melanoma-Differentiation-Associated Gene-5American Journal of Pathology200970
34An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory responseCell Death and Differentiation200968
35Dual Functions of Rift Valley Fever Virus NSs Protein: Inhibition of Host mRNA Transcription and Post‐transcriptional Downregulation of Protein Kinase PKRAnnals of the New York Academy of Sciences200965
36A catechol- O -methyltransferase that is essential for auditory function in mice and humansProceedings of the National Academy of Sciences of the United States of America200862
37ATP-sensitive potassium channels mediate survival during infection in mammals and insectsNature Genetics200761
38Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-Dependent Wasting Disease and Intestinal Inflammation in Gimap5-Deficient MiceJournal of Immunology201060
39Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in miceBlood201160
40X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11CProceedings of the National Academy of Sciences of the United States of America201157
41ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infectionsProceedings of the National Academy of Sciences of the United States of America201156
42Rapid Identification of a Disease Allele in Mouse Through Whole Genome Sequencing and Bulk Segregation AnalysisGenetics201156
43Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic dietProceedings of the National Academy of Sciences of the United States of America201154
44ENU-induced phenovariance in mice: inferences from 587 mutationsBMC Research Notes201246
45Precis on forward genetics in miceNature Immunology200742
46Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cellsProceedings of the National Academy of Sciences of the United States of America201038
47Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral InfectionPLoS Pathogens201238
48RNA and Imidazoquinolines Are Sensed by Distinct TLR7/8 Ectodomain Sites Resulting in Functionally Disparate Signaling EventsJournal of Immunology201438
49ZBTB1 is a determinant of lymphoid developmentJournal of Experimental Medicine201235
50LGP2: Positive about viral sensingProceedings of the National Academy of Sciences of the United States of America201033