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Top Articles

#TitleJournalYearCitations
1Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaNature20122,129
2BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against TuberculosisCell2018802
3K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomasActa Neuropathologica2012799
4PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast CancerCell Metabolism2015430
5Comparison of polarization properties of human adult microglia and blood‐derived macrophagesGlia2012393
6Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic typeNature Genetics2014383
7Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytomaNature Genetics2014381
8Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutationsActa Neuropathologica2012376
9Upper Airway Muscle Inflammation and Denervation Changes in Obstructive Sleep ApneaAmerican Journal of Respiratory and Critical Care Medicine2004292
10Trained immunity, tolerance, priming and differentiation: distinct immunological processesNature Immunology2021274
11Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomasActa Neuropathologica2013250
12Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutationsActa Neuropathologica2014211
13Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulationCancer2006208
14PTEN genomic deletion is associated with p‐Akt and AR signalling in poorer outcome, hormone refractory prostate cancerJournal of Pathology2009196
15Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinctActa Neuropathologica2011195
16Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMRNature Genetics2014167
17Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumoursBritish Journal of Cancer2009163
18Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndromeNature Genetics2018151
19Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in MetastasesCancer Cell2019151
20β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1Cell Reports2020147
21Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumorsActa Neuropathologica2016143
22The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate CancerArchives of Pathology and Laboratory Medicine2021143
23Accuracy of Urine Cytology and the Significance of an Atypical CategoryAmerican Journal of Clinical Pathology2009139
24Stalled developmental programs at the root of pediatric brain tumorsNature Genetics2019136
25A Recurrent PDGFRB Mutation Causes Familial Infantile MyofibromatosisAmerican Journal of Human Genetics2013135
26Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexesOncogene2011130
27DNA hypermethylation within TERT promoter upregulates TERT expression in cancerJournal of Clinical Investigation2018130
28SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancerNature Communications2019125
29Hypertonic Saline Resuscitation of Hemorrhagic Shock Diminishes Neutrophil Rolling and Adherence to Endothelium and Reduces In Vivo Vascular LeakageAnnals of Surgery2002118
30No small surprise – small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumourJournal of Pathology2014117
31Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencingHuman Mutation2010116
32Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomasActa Neuropathologica2014116
33Spatial heterogeneity in medulloblastomaNature Genetics2017112
34Infiltration of CD8 + T cells into tumor cell clusters in triple-negative breast cancerProceedings of the National Academy of Sciences of the United States of America2019108
35NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 proteinProceedings of the National Academy of Sciences of the United States of America201495
36Targeting innate immunity for tuberculosis vaccinationJournal of Clinical Investigation201995
37SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progressionNature Communications201494
38Mammographically non-calcified ductal carcinoma in situ: sonographic features with pathological correlation in 35 patientsClinical Radiology200993
39Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for GliomagenesisCell202093
40Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-CanadiansJournal of Allergy and Clinical Immunology201692
41Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancerNature Communications202192
42Accuracy of fine-needle aspiration cytology of axillary lymph nodes in breast cancer patientsCancer200891
43Alveolar macrophages and type I IFN in airway homeostasis and immunityTrends in Immunology201587
44Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activityCancer Cell202186
45Key Issues in Reporting Common Cancer Specimens: Problems in Pathologic Staging of Colon CancerArchives of Pathology and Laboratory Medicine200685
46Primary effusion lymphomaCancer200784
47Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicatorsOncoImmunology201778
48Renal cell carcinoma with inferior vena caval extention: impact of tumour extent on surgical outcomeBJU International200977
49CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovaryNature Communications201976
50Canadian Anaplastic Lymphoma Kinase Study: A Model for Multicenter Standardization and Optimization of ALK Testing in Lung CancerJournal of Thoracic Oncology201473