| # | Title | Journal | Year | Citations |
|---|
| 1 | Tackling the widespread and critical impact of batch effects in high-throughput data | Nature Reviews Genetics | 2010 | 1,641 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 3 | Resected adenocarcinoma of the pancreas?616 patients: results, outcomes, and prognostic indicators | Journal of Gastrointestinal Surgery | 2000 | 1,318 |
| 4 | The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints | Cancer Discovery | 2015 | 1,180 |
| 5 | Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens | Science | 1994 | 1,127 |
| 6 | Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma | Nature Genetics | 1994 | 1,063 |
| 7 | Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer | PLoS Medicine | 2006 | 894 |
| 8 | Identification of p53 gene mutations in bladder cancers and urine samples | Science | 1991 | 835 |
| 9 | Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment | Mayo Clinic Proceedings | 2016 | 832 |
| 10 | Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma | JAMA Oncology | 2017 | 750 |
| 11 | Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria | Science | 2018 | 733 |
| 12 | Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene | Science | 2009 | 713 |
| 13 | Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors | Science | 1992 | 698 |
| 14 | Short telomeres are a risk factor for idiopathic pulmonary fibrosis | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 665 |
| 15 | Functional normalization of 450k methylation array data improves replication in large cancer studies | Genome Biology | 2014 | 665 |
| 16 | Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer | Cancer Discovery | 2011 | 596 |
| 17 | Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer | Cancer Research | 2016 | 595 |
| 18 | The PIK3CA gene is mutated with high frequency in human breast cancers | Cancer Biology and Therapy | 2004 | 594 |
| 19 | Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia | Nature Medicine | 2012 | 584 |
| 20 | DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration | Nature | 2011 | 573 |
| 21 | Long-term Clinical Outcomes and Biomarker Analyses of Atezolizumab Therapy for Patients With Metastatic Triple-Negative Breast Cancer | JAMA Oncology | 2019 | 557 |
| 22 | Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation | Journal of Clinical Oncology | 2001 | 542 |
| 23 | Detectable clonal mosaicism from birth to old age and its relationship to cancer | Nature Genetics | 2012 | 511 |
| 24 | Screening for Early Pancreatic Neoplasia in High-Risk Individuals: A Prospective Controlled Study | Clinical Gastroenterology and Hepatology | 2006 | 493 |
| 25 | Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas | Cancer Research | 1997 | 492 |
| 26 | Facile Algae-Derived Route to Biogenic Silver Nanoparticles: Synthesis, Antibacterial, and Photocatalytic Properties | Langmuir | 2015 | 479 |
| 27 | Functionally defined therapeutic targets in diffuse intrinsic pontine glioma | Nature Medicine | 2015 | 473 |
| 28 | Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study | Lancet Oncology, The | 2017 | 402 |
| 29 | The life and death of DNA-PK | Oncogene | 2005 | 400 |
| 30 | The GLI gene is a member of the Kruppel family of zinc finger proteins | Nature | 1988 | 376 |
| 31 | Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors | ACS Chemical Biology | 2016 | 364 |
| 32 | Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review | BMC Public Health | 2012 | 356 |
| 33 | Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse | Blood | 2011 | 353 |
| 34 | Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas | Clinical Cancer Research | 2017 | 345 |
| 35 | SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer | Clinical Cancer Research | 2009 | 335 |
| 36 | Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia | Cancer Cell | 2014 | 324 |
| 37 | Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer | ELife | 2014 | 318 |
| 38 | Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab | Annals of the Rheumatic Diseases | 2017 | 317 |
| 39 | Mesothelin-specific CD8+ T Cell Responses Provide Evidence of In Vivo Cross-Priming by Antigen-Presenting Cells in Vaccinated Pancreatic Cancer Patients | Journal of Experimental Medicine | 2004 | 314 |
| 40 | Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. | Journal of Clinical Oncology | 1995 | 301 |
| 41 | Nuclear miRNA Regulates the Mitochondrial Genome in the Heart | Circulation Research | 2012 | 298 |
| 42 | Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer | Nature | 2014 | 284 |
| 43 | Value of p63 and Cytokeratin 5/6 as Immunohistochemical Markers for the Differential Diagnosis of Poorly Differentiated and Undifferentiated Carcinomas | American Journal of Clinical Pathology | 2001 | 283 |
| 44 | Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene | Cancer Research | 2000 | 273 |
| 45 | Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors | Cell | 2010 | 254 |
| 46 | STK11/LKB1 Peutz-Jeghers Gene Inactivation in Intraductal Papillary-Mucinous Neoplasms of the Pancreas | American Journal of Pathology | 2001 | 251 |
| 47 | Origin and molecular pathogenesis of ovarian high-grade serous carcinoma | Annals of Oncology | 2013 | 247 |
| 48 | Improved Detection and Characterization of Paroxysmal Nocturnal Hemoglobinuria Using Fluorescent Aerolysin | American Journal of Clinical Pathology | 2000 | 246 |
| 49 | Adjusting ferritin concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project | American Journal of Clinical Nutrition | 2017 | 246 |
| 50 | Interferon-κ, a Novel Type I Interferon Expressed in Human Keratinocytes | Journal of Biological Chemistry | 2001 | 238 |
