| # | Title | Journal | Year | Citations |
|---|
| 1 | Inadequate Antimicrobial Treatment of Infections | Chest | 1999 | 1,740 |
| 2 | The Influence of Inadequate Antimicrobial Treatment of Bloodstream Infections on Patient Outcomes in the ICU Setting | Chest | 2000 | 1,641 |
| 3 | Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results Database | Journal of Clinical Oncology | 2006 | 1,607 |
| 4 | Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia | NeuroImage | 2003 | 1,593 |
| 5 | Role of CD47 as a Marker of Self on Red Blood Cells | Science | 2000 | 1,505 |
| 6 | Proteogenomic characterization of human colon and rectal cancer | Nature | 2014 | 1,219 |
| 7 | Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor | Nature | 2010 | 1,192 |
| 8 | PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria | Science | 2013 | 1,040 |
| 9 | Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers | Cell | 2012 | 1,038 |
| 10 | Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells | Journal of Biological Chemistry | 1999 | 1,014 |
| 11 | CDK4/6 inhibition triggers anti-tumour immunity | Nature | 2017 | 998 |
| 12 | Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin | Science | 1994 | 930 |
| 13 | Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance | Science Translational Medicine | 2011 | 924 |
| 14 | Mannose 6-phosphate receptors: new twists in the tale | Nature Reviews Molecular Cell Biology | 2003 | 915 |
| 15 | Clinical Importance of Delays in the Initiation of Appropriate Antibiotic Treatment for Ventilator-Associated Pneumonia | Chest | 2002 | 912 |
| 16 | Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death | Immunity | 2004 | 844 |
| 17 | Polyomavirus-Associated Nephropathy in Renal Transplantation: Interdisciplinary Analyses and Recommendations | Transplantation | 2005 | 842 |
| 18 | Neutrophil serine proteases: specific regulators of inflammation | Nature Reviews Immunology | 2006 | 831 |
| 19 | Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells | Immunity | 2013 | 816 |
| 20 | Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 799 |
| 21 | Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine | Nature | 2012 | 766 |
| 22 | Lipotoxicity: when tissues overeat | Current Opinion in Lipidology | 2003 | 761 |
| 23 | Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 751 |
| 24 | Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin | Clinical Pharmacology and Therapeutics | 2008 | 743 |
| 25 | A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation | Critical Care Medicine | 1997 | 743 |
| 26 | Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis | Journal of Allergy and Clinical Immunology | 2012 | 731 |
| 27 | Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance | Immunity | 2007 | 715 |
| 28 | Widespread Lateral Gene Transfer from Intracellular Bacteria to Multicellular Eukaryotes | Science | 2007 | 693 |
| 29 | Clonal Architecture of Secondary Acute Myeloid Leukemia | New England Journal of Medicine | 2012 | 688 |
| 30 | A novel mouse model of lipotoxic cardiomyopathy | Journal of Clinical Investigation | 2001 | 666 |
| 31 | A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) | Nature Genetics | 1998 | 654 |
| 32 | Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development | Immunity | 2014 | 650 |
| 33 | AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch | Nature Immunology | 2012 | 646 |
| 34 | Improved Outcome Based on Fluid Management in Critically III Patients Requiring Pulmonary Artery Catheterization | The American Review of Respiratory Disease | 1992 | 621 |
| 35 | DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES | Annual Review of Immunology | 1999 | 613 |
| 36 | Incidence of BK with Tacrolimus Versus Cyclosporine and Impact of Preemptive Immunosuppression Reduction | American Journal of Transplantation | 2005 | 613 |
| 37 | Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase | Journal of Biological Chemistry | 1966 | 590 |
| 38 | SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses | Nature | 2021 | 586 |
| 39 | Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections | PLoS Pathogens | 2007 | 581 |
| 40 | Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth | Development (Cambridge) | 2003 | 568 |
| 41 | Prevalence of Depression in Adults With Diabetes: An epidemiological evaluation | Diabetes Care | 1993 | 552 |
| 42 | The Acute Respiratory Distress Syndrome | New England Journal of Medicine | 1995 | 552 |
| 43 | Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype | Nature | 2003 | 550 |
| 44 | Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex | Neuron | 1998 | 540 |
| 45 | Experience with a clinical guideline for the treatment of ventilator-associated pneumonia | Critical Care Medicine | 2001 | 536 |
| 46 | In vivo developmental stages in murine natural killer cell maturation | Nature Immunology | 2002 | 536 |
| 47 | AAV Vector Integration Sites in Mouse Hepatocellular Carcinoma | Science | 2007 | 532 |
| 48 | Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults | Nature Communications | 2016 | 523 |
| 49 | Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis | Journal of Neurochemistry | 2002 | 520 |
| 50 | Trafficking of lysosomal enzymes 1 | FASEB Journal | 1987 | 511 |
