| # | Title | Journal | Year | Citations |
|---|
| 1 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society | European Heart Journal | 2013 | 2,132 |
| 2 | Lipoprotein(a) as a cardiovascular risk factor: current status | European Heart Journal | 2010 | 1,392 |
| 3 | Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2020 | 776 |
| 4 | Genetically Elevated C-Reactive Protein and Ischemic Vascular Disease | New England Journal of Medicine | 2008 | 714 |
| 5 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 6 | A common coding variant in CASP8 is associated with breast cancer risk | Nature Genetics | 2007 | 591 |
| 7 | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 512 |
| 8 | Fasting and Nonfasting Lipid Levels | Circulation | 2008 | 484 |
| 9 | Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies | Lancet Neurology, The | 2012 | 445 |
| 10 | Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer | Critical Reviews in Clinical Laboratory Sciences | 2011 | 423 |
| 11 | Distribution of GLP-1 Binding Sites in the Rat Brain: Evidence that Exendin-4 is a Ligand of Brain GLP-1 Binding Sites | European Journal of Neuroscience | 1995 | 416 |
| 12 | Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR Review 1 | British Journal of Pharmacology | 2012 | 385 |
| 13 | Genome-wide association studies identify four ER negative–specific breast cancer risk loci | Nature Genetics | 2013 | 374 |
| 14 | Baseline C-Reactive Protein Is Associated With Incident Cancer and Survival in Patients With Cancer | Journal of Clinical Oncology | 2009 | 359 |
| 15 | Increased cardiac BNP expression associated with myocardial ischemia | FASEB Journal | 2003 | 323 |
| 16 | Melanopsin retinal ganglion cell loss in Alzheimer disease | Annals of Neurology | 2016 | 299 |
| 17 | Elevated HDL Cholesterol Is a Risk Factor for Ischemic Heart Disease in White Women When Caused by a Common Mutation in the Cholesteryl Ester Transfer Protein Gene | Circulation | 2000 | 288 |
| 18 | The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract | Journal of Neuroscience | 2002 | 281 |
| 19 | Haemostatic reference intervals in pregnancy | Thrombosis and Haemostasis | 2010 | 275 |
| 20 | ACE Gene Polymorphism in Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology | 2000 | 274 |
| 21 | C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization | International Journal of Obesity | 2011 | 267 |
| 22 | CHEK2*1100delC Genotyping for Clinical Assessment of Breast Cancer Risk: Meta-Analyses of 26,000 Patient Cases and 27,000 Controls | Journal of Clinical Oncology | 2008 | 262 |
| 23 | Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock | Journal of Neuroscience | 1997 | 259 |
| 24 | CA125 in ovarian cancer: European Group on Tumor Markers guidelines for clinical use | International Journal of Gynecological Cancer | 2005 | 257 |
| 25 | Negative statin-related news stories decrease statin persistence and increase myocardial infarction and cardiovascular mortality: a nationwide prospective cohort study | European Heart Journal | 2016 | 242 |
| 26 | Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but does not Induce Migraine | Cephalalgia | 2008 | 221 |
| 27 | Pituitary adenylate cyclase-activating peptide in the rat central nervous system: An immunohistochemical and in situ hybridization study | Journal of Comparative Neurology | 2002 | 216 |
| 28 | Base excess or buffer base (strong ion difference) as measure of a non‐respiratory acid‐base disturbance | Acta Anaesthesiologica Scandinavica | 1995 | 207 |
| 29 | Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38 | Brain | 2014 | 196 |
| 30 | PACAP and glutamate are co-stored in the retinohypothalamic tract | | 2000 | 189 |
| 31 | 25‐Hydroxyvitamin D and symptomatic ischemic stroke: An Original Study and Meta‐Analysis | Annals of Neurology | 2013 | 186 |
| 32 | Melanopsin Is Expressed in PACAP-Containing Retinal Ganglion Cells of the Human Retinohypothalamic Tract | | 2004 | 177 |
| 33 | Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant | Science Translational Medicine | 2013 | 170 |
| 34 | Serum YKL-40 and colorectal cancer | British Journal of Cancer | 1999 | 167 |
| 35 | Association of Mutations in the Apolipoprotein B Gene with Hypercholesterolemia and the Risk of Ischemic Heart Disease | New England Journal of Medicine | 1998 | 166 |
| 36 | Effect of Apolipoprotein M on High Density Lipoprotein Metabolism and Atherosclerosis in Low Density Lipoprotein Receptor Knock-out Mice | Journal of Biological Chemistry | 2008 | 165 |
| 37 | Lipoprotein(a) and Risk of Type 2 Diabetes | Clinical Chemistry | 2010 | 165 |
| 38 | Myocardial Infarction and Ischemic Heart Disease in Overweight and Obesity With and Without Metabolic Syndrome | JAMA Internal Medicine | 2014 | 165 |
| 39 | Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies | Brain | 2010 | 164 |
| 40 | Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow-up | Journal of Internal Medicine | 2011 | 163 |
| 41 | Isolation and characterization of human apolipoprotein M-containing lipoproteins | Journal of Lipid Research | 2006 | 157 |
| 42 | Dissociation between Light-Induced Phase Shift of the Circadian Rhythm and Clock Gene Expression in Mice Lacking the Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor | Journal of Neuroscience | 2001 | 154 |
| 43 | Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium | Human Molecular Genetics | 2011 | 152 |
| 44 | P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study | Heart Rhythm | 2015 | 152 |
| 45 | Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores | Nature Communications | 2021 | 140 |
| 46 | Hemochromatosis genotypes and risk of 31 disease endpoints: Meta-analyses including 66,000 cases and 226,000 controls | Hepatology | 2007 | 136 |
| 47 | miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke | Translational Stroke Research | 2014 | 136 |
| 48 | Target areas innervated by PACAP-immunoreactive retinal ganglion cells | Cell and Tissue Research | 2004 | 134 |
| 49 | Common Cholesteryl Ester Transfer Protein Mutations, Decreased HDL Cholesterol, and Possible Decreased Risk of Ischemic Heart Disease | Circulation | 2000 | 132 |
| 50 | Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population | Hepatology | 2020 | 132 |
