| # | Title | Journal | Year | Citations |
|---|
| 1 | A human gut microbial gene catalogue established by metagenomic sequencing | Nature | 2010 | 9,342 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Richness of human gut microbiome correlates with metabolic markers | Nature | 2013 | 3,641 |
| 4 | SignalP 5.0 improves signal peptide predictions using deep neural networks | Nature Biotechnology | 2019 | 3,317 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults | PLoS ONE | 2010 | 2,309 |
| 7 | Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life | Cell Host and Microbe | 2015 | 2,276 |
| 8 | An updated evolutionary classification of CRISPR–Cas systems | Nature Reviews Microbiology | 2015 | 2,081 |
| 9 | Biodiversity redistribution under climate change: Impacts on ecosystems and human well-being | Science | 2017 | 2,026 |
| 10 | ANGSD: Analysis of Next Generation Sequencing Data | BMC Bioinformatics | 2014 | 1,935 |
| 11 | An integrated catalog of reference genes in the human gut microbiome | Nature Biotechnology | 2014 | 1,664 |
| 12 | Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota | Nature | 2015 | 1,627 |
| 13 | Human gut microbes impact host serum metabolome and insulin sensitivity | Nature | 2016 | 1,506 |
| 14 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 15 | Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants | Nature Reviews Microbiology | 2020 | 1,427 |
| 16 | Fast and sensitive taxonomic classification for metagenomics with Kaiju | Nature Communications | 2016 | 1,406 |
| 17 | Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude | Science | 2010 | 1,339 |
| 18 | The genome of the cucumber, Cucumis sativus L. | Nature Genetics | 2009 | 1,317 |
| 19 | AdapterRemoval v2: rapid adapter trimming, identification, and read merging | BMC Research Notes | 2016 | 1,255 |
| 20 | Physiology of Cell Volume Regulation in Vertebrates | Physiological Reviews | 2009 | 1,229 |
| 21 | Function and Regulation of Ras | Annual Review of Biochemistry | 1993 | 1,167 |
| 22 | Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement | Nature Biotechnology | 2013 | 1,049 |
| 23 | TRY plant trait database – enhanced coverage and open access | Global Change Biology | 2020 | 1,038 |
| 24 | An Update of Wallace’s Zoogeographic Regions of the World | Science | 2013 | 1,037 |
| 25 | A high-resolution map of human evolutionary constraint using 29 mammals | Nature | 2011 | 1,016 |
| 26 | Mitogen-Activated Protein Kinase Signaling in Plants | Annual Review of Plant Biology | 2010 | 952 |
| 27 | Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes | Nature Biotechnology | 2014 | 909 |
| 28 | Monitoring endangered freshwater biodiversity using environmental DNA | Molecular Ecology | 2012 | 882 |
| 29 | Quantifying global soil carbon losses in response to warming | Nature | 2016 | 879 |
| 30 | DeepLoc: prediction of protein subcellular localization using deep learning | Bioinformatics | 2017 | 876 |
| 31 | Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer | Gut | 2017 | 865 |
| 32 | Integration within the Felsenstein equation for improved Markov chain Monte Carlo methods in population genetics | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 864 |
| 33 | Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans | Nature | 2014 | 821 |
| 34 | Social Immunity | Current Biology | 2007 | 804 |
| 35 | Global assessment of experimental climate warming on tundra vegetation: heterogeneity over space and time | Ecology Letters | 2012 | 764 |
| 36 | Ancient human genome sequence of an extinct Palaeo-Eskimo | Nature | 2010 | 750 |
| 37 | Detection of a Diverse Marine Fish Fauna Using Environmental DNA from Seawater Samples | PLoS ONE | 2012 | 747 |
| 38 | Fungal community analysis by high‐throughput sequencing of amplified markers – a user's guide | New Phytologist | 2013 | 747 |
| 39 | Plot-scale evidence of tundra vegetation change and links to recent summer warming | Nature Climate Change | 2012 | 745 |
| 40 | Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse | Nature | 2013 | 717 |
| 41 | Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise | Experimental Physiology | 2009 | 709 |
| 42 | Recent functional insights into the role of (p)ppGpp in bacterial physiology | Nature Reviews Microbiology | 2015 | 703 |
| 43 | Distinct DNA methylomes of newborns and centenarians | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 687 |
| 44 | Large-scale association analyses identify host factors influencing human gut microbiome composition | Nature Genetics | 2021 | 676 |
| 45 | An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia | Science | 2011 | 675 |
| 46 | Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 674 |
| 47 | Effectiveness of terrestrial protected areas in reducing habitat loss and population declines | Biological Conservation | 2013 | 673 |
| 48 | Intensive agriculture reduces soil biodiversity across Europe | Global Change Biology | 2015 | 641 |
| 49 | An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People | Science | 2012 | 626 |
| 50 | Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney Tumor | Cell | 2012 | 622 |
