| # | Title | Journal | Year | Citations |
|---|
| 1 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 2 | Richness of human gut microbiome correlates with metabolic markers | Nature | 2013 | 3,641 |
| 3 | eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses | Nucleic Acids Research | 2019 | 2,575 |
| 4 | Proposed minimal standards for the use of genome data for the taxonomy of prokaryotes | International Journal of Systematic and Evolutionary Microbiology | 2018 | 2,359 |
| 5 | Fast Genome-Wide Functional Annotation through Orthology Assignment by eggNOG-Mapper | Molecular Biology and Evolution | 2017 | 2,156 |
| 6 | Gut microbiota in human metabolic health and disease | Nature Reviews Microbiology | 2021 | 1,960 |
| 7 | eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences | Nucleic Acids Research | 2016 | 1,937 |
| 8 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update | Annals of the Rheumatic Diseases | 2020 | 1,860 |
| 9 | Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals | Nature Genetics | 2018 | 1,835 |
| 10 | Trends in GPCR drug discovery: new agents, targets and indications | Nature Reviews Drug Discovery | 2017 | 1,773 |
| 11 | An integrated catalog of reference genes in the human gut microbiome | Nature Biotechnology | 2014 | 1,664 |
| 12 | Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota | Nature | 2015 | 1,627 |
| 13 | Mass-spectrometric exploration of proteome structure and function | Nature | 2016 | 1,573 |
| 14 | Human gut microbes impact host serum metabolome and insulin sensitivity | Nature | 2016 | 1,506 |
| 15 | Occlusal Caries: Biological Approach for Its Diagnosis and Management | Caries Research | 2016 | 1,469 |
| 16 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 17 | Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium | Clinical Infectious Diseases | 2020 | 1,429 |
| 18 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 19 | Genome-wide association study identifies 74 loci associated with educational attainment | Nature | 2016 | 1,204 |
| 20 | Homogenous 96-Plex PEA Immunoassay Exhibiting High Sensitivity, Specificity, and Excellent Scalability | PLoS ONE | 2014 | 1,195 |
| 21 | STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data | Nucleic Acids Research | 2016 | 1,112 |
| 22 | Liver-Related Deaths in Persons Infected With the Human Immunodeficiency Virus | Archives of Internal Medicine | 2006 | 1,004 |
| 23 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 24 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 25 | Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease | Nature Genetics | 2014 | 938 |
| 26 | The SIDER database of drugs and side effects | Nucleic Acids Research | 2016 | 914 |
| 27 | SignalP 6.0 predicts all five types of signal peptides using protein language models | Nature Biotechnology | 2022 | 883 |
| 28 | Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves | New England Journal of Medicine | 2015 | 874 |
| 29 | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses | Nature Genetics | 2016 | 870 |
| 30 | Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer | Gut | 2017 | 865 |
| 31 | The glymphatic pathway in neurological disorders | Lancet Neurology, The | 2018 | 831 |
| 32 | Gestational diabetes mellitus | Nature Reviews Disease Primers | 2019 | 811 |
| 33 | The oral microbiome – an update for oral healthcare professionals | British Dental Journal | 2016 | 782 |
| 34 | Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease | Cellular and Molecular Life Sciences | 2018 | 777 |
| 35 | Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse | Nature | 2013 | 717 |
| 36 | Enterotypes in the landscape of gut microbial community composition | Nature Microbiology | 2018 | 717 |
| 37 | ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA | Cell | 2013 | 714 |
| 38 | Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility | Physiological Reviews | 2016 | 700 |
| 39 | A review of the use of virtual reality head-mounted displays in education and training | Education and Information Technologies | 2018 | 698 |
| 40 | Replication fork stability confers chemoresistance in BRCA-deficient cells | Nature | 2016 | 685 |
| 41 | Large-scale association analyses identify host factors influencing human gut microbiome composition | Nature Genetics | 2021 | 676 |
| 42 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 43 | Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation | Cell Reports | 2013 | 619 |
| 44 | Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci | Nature Genetics | 2016 | 617 |
| 45 | An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans | Diabetes | 2017 | 615 |
| 46 | Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation | Nature Medicine | 2019 | 602 |
| 47 | EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure | Journal of Hepatology | 2017 | 601 |
| 48 | Strong signatures of selection in the domestic pig genome | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 548 |
| 49 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche | Nature | 2014 | 548 |
| 50 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
