| # | Title | Journal | Year | Citations |
|---|
| 1 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
| 2 | Renal cell carcinoma | Nature Reviews Disease Primers | 2017 | 1,727 |
| 3 | Proteogenomics connects somatic mutations to signalling in breast cancer | Nature | 2016 | 1,384 |
| 4 | Macrophages as regulators of tumour immunity and immunotherapy | Nature Reviews Immunology | 2019 | 1,365 |
| 5 | Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma | New England Journal of Medicine | 2021 | 961 |
| 6 | Multi-platform discovery of haplotype-resolved structural variation in human genomes | Nature Communications | 2019 | 636 |
| 7 | Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma | Cell | 2019 | 629 |
| 8 | Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal | Cell | 2018 | 609 |
| 9 | Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines | Cell Systems | 2018 | 605 |
| 10 | Mechanisms of aromatase inhibitor resistance | Nature Reviews Cancer | 2015 | 319 |
| 11 | The Physician-Scientist Career Pipeline in 2005 | JAMA - Journal of the American Medical Association | 2005 | 317 |
| 12 | Acquired copy number alterations in adult acute myeloid leukemia genomes | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 231 |
| 13 | Regulation of hematopoietic stem cells by bone marrow stromal cells | Trends in Immunology | 2014 | 231 |
| 14 | Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia | Blood | 2015 | 207 |
| 15 | Acetate Promotes T Cell Effector Function during Glucose Restriction | Cell Reports | 2019 | 205 |
| 16 | Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome | Molecular and Cellular Biology | 2008 | 180 |
| 17 | Acquired HER2 mutations in ER+ metastatic breast cancer confer resistance to estrogen receptor–directed therapies | Nature Genetics | 2019 | 170 |
| 18 | VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 159 |
| 19 | The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma | Cell Reports | 2017 | 153 |
| 20 | YB-1 Is Important for Late-Stage Embryonic Development, Optimal Cellular Stress Responses, and the Prevention of Premature Senescence | Molecular and Cellular Biology | 2005 | 151 |
| 21 | ARF Impedes NPM/B23 Shuttling in an Mdm2-Sensitive Tumor Suppressor Pathway | Molecular and Cellular Biology | 2004 | 148 |
| 22 | Recurrent somatic mutations affecting B-cell receptor signaling pathway genes in follicular lymphoma | Blood | 2017 | 147 |
| 23 | Identification of a Novel <emph type="ital">TP53</emph> Cancer Susceptibility Mutation Through Whole-Genome Sequencing of a Patient With Therapy-Related AML | JAMA - Journal of the American Medical Association | 2011 | 146 |
| 24 | Prognostic Value of a Long Non-coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma | European Urology | 2018 | 144 |
| 25 | Genome-wide discovery of loci influencing chemotherapy cytotoxicity | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 142 |
| 26 | TGF-β suppresses type 2 immunity to cancer | Nature | 2020 | 137 |
| 27 | Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy | Nature Communications | 2017 | 135 |
| 28 | An activated receptor tyrosine kinase, TEL/PDGF R, cooperates with AML1/ETO to induce acute myeloid leukemia in mice | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 124 |
| 29 | Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma | Cancer Cell | 2022 | 120 |
| 30 | Neutrophil Elastase Cleaves PML-RARα and Is Important for the Development of Acute Promyelocytic Leukemia in Mice | Cell | 2003 | 116 |
| 31 | The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 107 |
| 32 | Pharmacogenomic assessment of carboxylesterases 1 and 2 | Genomics | 2004 | 105 |
| 33 | Randomized Double-Blind Phase II Study of Maintenance Pembrolizumab Versus Placebo After First-Line Chemotherapy in Patients With Metastatic Urothelial Cancer | Journal of Clinical Oncology | 2020 | 102 |
| 34 | Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia | Journal of Clinical Investigation | 2010 | 101 |
| 35 | Cell death induced by granzyme C | Blood | 2003 | 99 |
| 36 | Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy | International Journal of Breast Cancer | 2012 | 97 |
| 37 | miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221 | Blood | 2009 | 96 |
| 38 | Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan‐omics precision | Journal of Pathology | 2018 | 93 |
| 39 | MLL fusions: Pathways to leukemia | Cancer Biology and Therapy | 2009 | 92 |
| 40 | A phase 1b study of AFM13 in combination with pembrolizumab in patients with relapsed or refractory Hodgkin lymphoma | Blood | 2020 | 92 |
| 41 | Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma | JCI Insight | 2017 | 89 |
| 42 | 696O_PR Nivolumab + cabozantinib vs sunitinib in first-line treatment for advanced renal cell carcinoma: First results from the randomized phase III CheckMate 9ER trial | Annals of Oncology | 2020 | 86 |
| 43 | Nucleolar Adaptation in Human Cancer | Cancer Investigation | 2005 | 73 |
| 44 | Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice | Blood | 2011 | 72 |
| 45 | Cold Shock Domain Family Members YB-1 and MSY4 Share Essential Functions during Murine Embryogenesis | Molecular and Cellular Biology | 2006 | 68 |
| 46 | Clinical application of hematopoietic progenitor cell expansion: current status and future prospects | Bone Marrow Transplantation | 2003 | 63 |
| 47 | Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection | Nature Communications | 2017 | 61 |
| 48 | ΔNp63 Inhibits Oxidative Stress-Induced Cell Death, Including Ferroptosis, and Cooperates with the BCL-2 Family to Promote Clonogenic Survival | Cell Reports | 2017 | 61 |
| 49 | A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 55 |
| 50 | Species Selectivity of Mixed-Lineage Leukemia/Trithorax and HCF Proteolytic Maturation Pathways | Molecular and Cellular Biology | 2007 | 55 |
