| # | Title | Journal | Year | Citations |
|---|
| 1 | Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity | NeuroSignals | 2013 | 7,097 |
| 2 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
| 3 | Transglutaminases: Nature’s biological glues | Biochemical Journal | 2002 | 955 |
| 4 | A large-scale evaluation of computational protein function prediction | Nature Methods | 2013 | 789 |
| 5 | Transmembrane helices predicted at 95% accuracy | Protein Science | 1995 | 628 |
| 6 | Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracy | Protein Science | 1996 | 574 |
| 7 | PredGPI: a GPI-anchor predictor | BMC Bioinformatics | 2008 | 553 |
| 8 | Comparative and demographic analysis of orang-utan genomes | Nature | 2011 | 541 |
| 9 | Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders | PLoS Genetics | 2012 | 358 |
| 10 | Mitochondrial cytochrome b: evolution and structure of the protein | Biochimica Et Biophysica Acta - Bioenergetics | 1993 | 328 |
| 11 | The history of the cholinergic hypothesis | Behavioural Brain Research | 2011 | 319 |
| 12 | The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE 2 production in response to TNF‐α | FASEB Journal | 2003 | 313 |
| 13 | Roles of NMDA receptor activity and nitric oxide production in brain development | Brain Research Reviews | 2000 | 309 |
| 14 | BaCelLo: a balanced subcellular localization predictor | Bioinformatics | 2006 | 309 |
| 15 | pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant | Biochemical and Biophysical Research Communications | 2005 | 259 |
| 16 | WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation | BMC Genomics | 2013 | 248 |
| 17 | Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats | Neuroscience Letters | 2000 | 226 |
| 18 | Microglia and neuroprotection: From in vitro studies to therapeutic applications | Progress in Neurobiology | 2010 | 226 |
| 19 | Prediction of coordination number and relative solvent accessibility in proteins | Proteins: Structure, Function and Bioinformatics | 2002 | 222 |
| 20 | The implications of alternative splicing in the ENCODE protein complement | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 206 |
| 21 | Mutations in the 5′ UTR of ANKRD26, the Ankirin Repeat Domain 26 Gene, Cause an Autosomal-Dominant Form of Inherited Thrombocytopenia, THC2 | American Journal of Human Genetics | 2011 | 200 |
| 22 | Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection | Current Molecular Pharmacology | 2009 | 195 |
| 23 | Reciprocal Interactions Between Microglia and Neurons: From Survival to Neuropathology | Reviews in the Neurosciences | 2002 | 188 |
| 24 | Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro | Cerebellum | 2002 | 180 |
| 25 | A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder | Human Genetics | 2012 | 180 |
| 26 | Disruption at the PTCHD1 Locus on Xp22.11 in Autism Spectrum Disorder and Intellectual Disability | Science Translational Medicine | 2010 | 178 |
| 27 | Changes in the root‐associated fungal communities along a primary succession gradient analysed by 454 pyrosequencing | Molecular Ecology | 2012 | 172 |
| 28 | A Whole-Genome Scan and Fine-Mapping Linkage Study of Auditory-Visual Synesthesia Reveals Evidence of Linkage to Chromosomes 2q24, 5q33, 6p12, and 12p12 | American Journal of Human Genetics | 2009 | 170 |
| 29 | Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein | Neurotoxicity Research | 2010 | 167 |
| 30 | Vitamin C content and antioxidant activity of the fruit and of the Ayurvedic preparation of Emblica officinalis Gaertn. | Journal of Ethnopharmacology | 2006 | 155 |
| 31 | The Bacterial Response to the Chalcogen Metalloids Se and Te | Advances in Microbial Physiology | 2007 | 152 |
| 32 | Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation | Neurochemistry International | 2004 | 149 |
| 33 | High performance of vegetables, flowers, and medicinal plants in a red-blue LED incubator for indoor plant production | Agronomy for Sustainable Development | 2014 | 149 |
| 34 | Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines | Journal of Experimental Medicine | 2002 | 146 |
| 35 | H+/ATP ratio of proton transport-coupled ATP synthesis and hydrolysis catalysed by CF0F1-liposomes | EMBO Journal | 2003 | 145 |
| 36 | SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability | PLoS Genetics | 2011 | 136 |
| 37 | A TrkA-to-p75NTR molecular switch activates amyloid β-peptide generation during aging | Biochemical Journal | 2005 | 134 |
| 38 | Characterization of a Family with Rare Deletions in CNTNAP5 and DOCK4 Suggests Novel Risk Loci for Autism and Dyslexia | Biological Psychiatry | 2010 | 131 |
| 39 | Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide | Journal of Neurochemistry | 2004 | 128 |
| 40 | High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L–DOCK4 gene region in autism susceptibility | Molecular Psychiatry | 2010 | 126 |
| 41 | The thermodynamic H + /ATP ratios of the H + -ATPsynthases from chloroplasts and Escherichia coli | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 125 |
| 42 | In vivo transcriptional regulation of N-Myc target genes is controlled by E-box methylation | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 123 |
| 43 | An initial comparative map of copy number variations in the goat (Capra hircus) genome | BMC Genomics | 2010 | 120 |
| 44 | Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy | FEBS Letters | 1994 | 119 |
| 45 | Structural Role of PufX in the Dimerization of the Photosynthetic Core Complex of Rhodobacter sphaeroides | Journal of Biological Chemistry | 2004 | 116 |
| 46 | Lipid fluidity and membrane protein dynamics | Bioscience Reports | 1987 | 115 |
| 47 | Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons | Brain Research | 1996 | 115 |
| 48 | Metabolomic Investigation of the Bacterial Response to a Metal Challenge | Applied and Environmental Microbiology | 2009 | 110 |
| 49 | INPS: predicting the impact of non-synonymous variations on protein stability from sequence | Bioinformatics | 2015 | 109 |
| 50 | Loss of miR‐101 expression promotes Wnt/β‐catenin signalling pathway activation and malignancy in colon cancer cells | Journal of Pathology | 2013 | 105 |
