| # | Title | Journal | Year | Citations |
|---|
| 1 | Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome | Nature Genetics | 1996 | 732 |
| 2 | Autosomal dominant hypocalcaemia caused by a Ca2+-sensing receptor gene mutation | Nature Genetics | 1994 | 566 |
| 3 | Long-term Complications of Congenital Esophageal Atresia and/or Tracheoesophageal Fistula | Chest | 2004 | 339 |
| 4 | Utility of whole‐exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care | Clinical Genetics | 2016 | 323 |
| 5 | What is the physiological time to recovery after concussion? A systematic review | British Journal of Sports Medicine | 2017 | 281 |
| 6 | The Effect of Computerized Physician Order Entry on Medication Errors and Adverse Drug Events in Pediatric Inpatients | Pediatrics | 2003 | 252 |
| 7 | Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis | Journal of Pediatrics | 2005 | 238 |
| 8 | Increased Immune Reactivity Predicts Aggressive Complicating Crohn's Disease in Children | Clinical Gastroenterology and Hepatology | 2008 | 231 |
| 9 | Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis | Archives of Disease in Childhood: Fetal and Neonatal Edition | 2012 | 216 |
| 10 | Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry | Pediatric Neurology | 2017 | 213 |
| 11 | Type 2 Diabetes, Medication-Induced Diabetes, and Monogenic Diabetes in Canadian Children | Diabetes Care | 2010 | 201 |
| 12 | Elevated sleep arousal thresholds in enuretic boys: clinical implications | Acta Paediatrica, International Journal of Paediatrics | 1997 | 171 |
| 13 | A Systematic Review of the Use of the Ketogenic Diet in Childhood Epilepsy | Pediatric Neurology | 2006 | 167 |
| 14 | Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology | Autoimmunity Reviews | 2012 | 155 |
| 15 | Laboratory Values for Children With Newly Diagnosed Inflammatory Bowel Disease | Pediatrics | 2007 | 149 |
| 16 | Lorazepam vs Diazepam for Pediatric Status Epilepticus | JAMA - Journal of the American Medical Association | 2014 | 143 |
| 17 | Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1 | Journal of Biological Chemistry | 2003 | 132 |
| 18 | Prevalence of complications in children with chronic kidney disease according to KDOQI | Kidney International | 2006 | 131 |
| 19 | Translational Induction of the Inhibitor of Apoptosis Protein HIAP2 during Endoplasmic Reticulum Stress Attenuates Cell Death and Is Mediated via an Inducible Internal Ribosome Entry Site Element | Journal of Biological Chemistry | 2004 | 130 |
| 20 | Bone and mineral abnormalities in childhood acute lymphoblastic leukemia: Influence of disease, drugs and nutrition | International Journal of Cancer | 1998 | 126 |
| 21 | Hypertension in children: new trends and challenges | Clinical Science | 2010 | 119 |
| 22 | Exhaled Nitric Oxide Concentration Is Affected by Age, Height, and Race in Healthy 9- to 12-Year-Old Children | Chest | 2008 | 115 |
| 23 | Mesenchymal Stromal Cell Therapy in Bronchopulmonary Dysplasia: Systematic Review and Meta-Analysis of Preclinical Studies | Stem Cells Translational Medicine | 2017 | 113 |
| 24 | Guanidinoacetate methyltransferase (GAMT) deficiency: Outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring | Molecular Genetics and Metabolism | 2014 | 111 |
| 25 | Inconclusive Diagnosis of Cystic Fibrosis After Newborn Screening | Pediatrics | 2015 | 105 |
| 26 | Neural tube defects in Eastern Ontario and Western Quebec: Demography and family data | American Journal of Medical Genetics Part A | 1984 | 99 |
| 27 | Initial evaluation of heart murmurs: are laboratory tests necessary? | Pediatrics | 1990 | 98 |
| 28 | Impact of Prenatal Risk Factors on Congenital Heart Disease in the Current Era | Journal of the American Heart Association | 2013 | 97 |
| 29 | A randomized, double-blind, placebo-controlled noninferiority trial of amoxicillin for clinically diagnosed acute otitis media in children 6 months to 5 years of age | Cmaj | 2005 | 94 |
| 30 | Bisphosphonate therapy for children and adolescents with secondary osteoporosis | The Cochrane Library | 2010 | 87 |
| 31 | Quality of life during active treatment for pediatric acute lymphoblastic leukemia | International Journal of Cancer | 2011 | 87 |
| 32 | The Utility of DXA Assessment at the Forearm, Proximal Femur, and Lateral Distal Femur, and Vertebral Fracture Assessment in the Pediatric Population: 2019 ISCD Official Position | Journal of Clinical Densitometry | 2019 | 83 |
| 33 | Ketogenic diet in the treatment of refractory epilepsy in childhood | Pediatric Neurology | 1999 | 82 |
| 34 | Validity, Reliability, and Responsiveness of a New Measure of Health-Related Quality of Life in Children with Immune Thrombocytopenic Purpura: The Kids’ ITP Tools | Journal of Pediatrics | 2007 | 82 |
| 35 | Cognitive Changes in Children Treated for Acute Lymphoblastic Leukemia With Chemotherapy Only According to the Pediatric Oncology Group 9605 Protocol | Journal of Child Neurology | 2005 | 78 |
| 36 | Identification of paediatric cancer patients with poor quality of life | British Journal of Cancer | 2009 | 75 |
| 37 | Epidemiological survey of central nervous system germ cell tumors in Canadian children | Journal of Neuro-Oncology | 2007 | 74 |
| 38 | Evaluation of renal scars by technetium-labeled dimercaptosuccinic acid scan, intravenous urography, and ultrasonography: A comparative study | Journal of Pediatrics | 1992 | 72 |
| 39 | Inter‐ and intra‐rater reliability of neck circumference measurements in children | Pediatric Pulmonology | 2009 | 72 |
| 40 | Real-time tool to display the predicted disease course and treatment response for children with Crohnʼs disease | Inflammatory Bowel Diseases | 2011 | 72 |
| 41 | Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis | Kidney International | 2012 | 72 |
| 42 | Culture Versus Biology: Children's Attitudes Toward Thinness and Fatness | Pediatrics | 1988 | 72 |
| 43 | Nocturnal hypoventilation: predictors and outcomes in childhood progressive neuromuscular disease | Archives of Disease in Childhood | 2010 | 71 |
| 44 | High-risk STD/HIV behavior among college students | JAMA - Journal of the American Medical Association | 1990 | 70 |
| 45 | Culture versus biology: children's attitudes toward thinness and fatness | Pediatrics | 1988 | 70 |
| 46 | The impact of COVID-19 on adolescents with eating disorders: a cohort study | Journal of Eating Disorders | 2021 | 68 |
| 47 | Prevalence and significance of mild bleeding disorders in children with recurrent epistaxis | Journal of Pediatrics | 1988 | 66 |
| 48 | Outcome and life prospects after surgical management of medically intractable epilepsy in patients under 18 years of age | Child's Nervous System | 1997 | 64 |
| 49 | Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review | BMC Complementary and Alternative Medicine | 2006 | 64 |
| 50 | Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia | Journal of Medical Genetics | 2014 | 64 |
