| # | Title | Journal | Year | Citations |
|---|
| 1 | Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy | Science | 2005 | 4,792 |
| 2 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans | Nature | 2000 | 4,315 |
| 3 | Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation | Science | 1983 | 3,205 |
| 4 | MAP kinase signalling cascade in Arabidopsis innate immunity | Nature | 2002 | 2,407 |
| 5 | Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: Recommendations of the RTOG-ASTRO Phoenix Consensus Conference | International Journal of Radiation Oncology Biology Physics | 2006 | 2,320 |
| 6 | A review of the optical properties of biological tissues | IEEE Journal of Quantum Electronics | 1990 | 2,121 |
| 7 | Infliximab Maintenance Therapy for Fistulizing Crohn's Disease | New England Journal of Medicine | 2004 | 2,026 |
| 8 | Relation of cue to consequence in avoidance learning | Learning and Behavior | 1966 | 1,926 |
| 9 | Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites | Science | 2009 | 1,806 |
| 10 | A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology | Cell | 2008 | 1,766 |
| 11 | Specific Genetic Predictors of Chemotherapeutic Response and Survival in Patients With Anaplastic Oligodendrogliomas | Journal of the National Cancer Institute | 1998 | 1,759 |
| 12 | Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter | Nature | 2011 | 1,596 |
| 13 | Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase | Science | 1994 | 1,567 |
| 14 | Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker | Science | 1999 | 1,477 |
| 15 | Neuronal subtype specification in the cerebral cortex | Nature Reviews Neuroscience | 2007 | 1,444 |
| 16 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 17 | Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice | Neuron | 2001 | 1,419 |
| 18 | Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 1,412 |
| 19 | The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites | Developmental Cognitive Neuroscience | 2018 | 1,282 |
| 20 | A central integrator of transcription networks in plant stress and energy signalling | Nature | 2007 | 1,270 |
| 21 | Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease | Infection and Immunity | 2000 | 1,138 |
| 22 | Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study | Lancet Oncology, The | 2015 | 1,100 |
| 23 | Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. | Circulation | 1991 | 1,096 |
| 24 | Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor | Nature Biotechnology | 2014 | 1,060 |
| 25 | Glucosinolate Metabolites Required for an Arabidopsis Innate Immune Response | Science | 2009 | 1,037 |
| 26 | Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper | Journal of Extracellular Vesicles | 2015 | 1,020 |
| 27 | Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness | Science | 1981 | 995 |
| 28 | Lessons from phase III clinical trials on anti-VEGF therapy for cancer | Nature Clinical Practice Oncology | 2006 | 968 |
| 29 | Attention-deficit/hyperactivity disorder | Nature Reviews Disease Primers | 2015 | 959 |
| 30 | A Compilation of Singlet Oxygen Yields from Biologically Relevant Molecules | Photochemistry and Photobiology | 1999 | 943 |
| 31 | Preventable Anesthesia Mishaps | Anesthesiology | 1978 | 924 |
| 32 | Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study | Lancet, The | 2009 | 883 |
| 33 | Laser speckle contrast imaging in biomedical optics | Journal of Biomedical Optics | 2010 | 862 |
| 34 | Nontyphoidal Salmonellosis | Clinical Infectious Diseases | 2001 | 861 |
| 35 | Are innate immune signaling pathways in plants and animals conserved? | Nature Immunology | 2005 | 844 |
| 36 | Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2 | Nature | 1997 | 830 |
| 37 | Hexokinase as a sugar sensor in higher plants. | Plant Cell | 1997 | 818 |
| 38 | TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop | Nature Cell Biology | 2013 | 796 |
| 39 | An Analysis of the Lowest Effective Intensity of Prophylactic Anticoagulation for Patients with Nonrheumatic Atrial Fibrillation | New England Journal of Medicine | 1996 | 790 |
| 40 | A cyclic AMP- and phorbol ester-inducible DNA element | Nature | 1986 | 775 |
| 41 | PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE | Transplantation | 1973 | 765 |
| 42 | Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis | Cell | 2015 | 746 |
| 43 | Multiple neural spike train data analysis: state-of-the-art and future challenges | Nature Neuroscience | 2004 | 734 |
| 44 | Molecular Mechanisms of Bacterial Virulence Elucidated Using a Pseudomonas aeruginosa– Caenorhabditis elegans Pathogenesis Model | Cell | 1999 | 721 |
| 45 | Macrophages Facilitate Electrical Conduction in the Heart | Cell | 2017 | 703 |
| 46 | Therapeutic siRNA silencing in inflammatory monocytes in mice | Nature Biotechnology | 2011 | 697 |
| 47 | Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity | Journal of Biological Chemistry | 1999 | 688 |
| 48 | A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family | Cell | 1989 | 675 |
| 49 | Risk for New Onset of Depression During the Menopausal Transition | Archives of General Psychiatry | 2006 | 667 |
| 50 | Therapeutic application of histone deacetylase inhibitors for central nervous system disorders | Nature Reviews Drug Discovery | 2008 | 650 |
