| # | Title | Journal | Year | Citations |
|---|
| 1 | Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives | European Journal of Medicinal Chemistry | 2014 | 255 |
| 2 | Inflammasome Priming by Lipopolysaccharide Is Dependent upon ERK Signaling and Proteasome Function | Journal of Immunology | 2014 | 188 |
| 3 | A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection | European Journal of Pharmaceutical Sciences | 2020 | 172 |
| 4 | Naringenin attenuates cisplatin nephrotoxicity in rats | Life Sciences | 2005 | 167 |
| 5 | <p>Antiviral potential of green synthesized silver nanoparticles of <em>Lampranthus coccineus</em> and <em>Malephora lutea</em></p> | International Journal of Nanomedicine | 2019 | 156 |
| 6 | In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting | Acta Pharmaceutica Sinica B | 2015 | 148 |
| 7 | Synthesis, antitumor activity and molecular docking study of novel Sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives | European Journal of Medicinal Chemistry | 2010 | 138 |
| 8 | Acylated flavonol glycosides from Eugenia jambolana leaves | Phytochemistry | 2001 | 124 |
| 9 | Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia | Biomolecules | 2020 | 110 |
| 10 | <p>Recent expansions of novel strategies towards the drug targeting into the brain</p> | International Journal of Nanomedicine | 2019 | 105 |
| 11 | Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety | European Journal of Medicinal Chemistry | 2014 | 104 |
| 12 | Cellular uptake, cytotoxicity and in-vivo evaluation of Tamoxifen citrate loaded niosomes | International Journal of Pharmaceutics | 2015 | 96 |
| 13 | Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies | Journal of Enzyme Inhibition and Medicinal Chemistry | 2018 | 88 |
| 14 | Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014–2016) | Electrophoresis | 2017 | 87 |
| 15 | Characterization of Pseudomonas aeruginosa isolated from clinical and environmental samples in Minia, Egypt: prevalence, antibiogram and resistance mechanisms | Journal of Antimicrobial Chemotherapy | 2007 | 86 |
| 16 | Formulation, Characterization, and Clinical Evaluation of Microemulsion Containing Clotrimazole for Topical Delivery | AAPS PharmSciTech | 2011 | 86 |
| 17 | Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells | Biochemical Pharmacology | 2009 | 85 |
| 18 | Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]Pyrimidine derivatives for their anti-inflammatory and anti-microbial activities | European Journal of Medicinal Chemistry | 2010 | 82 |
| 19 | Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents | European Journal of Medicinal Chemistry | 2019 | 81 |
| 20 | Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2 | Colloids and Surfaces B: Biointerfaces | 2021 | 81 |
| 21 | Novel 6,8-dibromo-4(3H)quinazolinone derivatives of anti-bacterial and anti-fungal activities | European Journal of Medicinal Chemistry | 2010 | 78 |
| 22 | The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways | PLoS ONE | 2017 | 76 |
| 23 | Therapeutic Drug Monitoring and Clinical Outcomes in Epileptic Egyptian Patients: A Gene Polymorphism Perspective Study | Therapeutic Drug Monitoring | 2007 | 73 |
| 24 | Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran–pyrazole derivatives as anticancer agents | Bioorganic Chemistry | 2015 | 73 |
| 25 | Ziziphus spina-christi fruit extract suppresses oxidative stress and p38 MAPK expression in ulcerative colitis in rats via induction of Nrf2 and HO-1 expression | Food and Chemical Toxicology | 2018 | 73 |
| 26 | The protective effect of Phoenix dactylifera L. seeds against CCl4-induced hepatotoxicity in rats | Journal of Ethnopharmacology | 2014 | 72 |
| 27 | Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste | Saudi Pharmaceutical Journal | 2020 | 71 |
| 28 | Anticancer and Antioxidant Tannins from Pimenta dioica Leaves | Zeitschrift Fur Naturforschung - Section C Journal of Biosciences | 2007 | 69 |
| 29 | Synthesis of Certain Pyrimidine Derivatives as Antimicrobial Agents and Anti-Inflammatory Agents | Molecules | 2010 | 69 |
| 30 | Metabolomics analysis and biological investigation of three Malvaceae plants | Phytochemical Analysis | 2020 | 66 |
| 31 | Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice | Food and Chemical Toxicology | 2007 | 65 |
| 32 | Synthesis of certain pyrrole derivatives as antimicro-bial agents | Acta Pharmaceutica | 2009 | 64 |
| 33 | Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide | European Journal of Medicinal Chemistry | 2010 | 64 |
| 34 | Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia–reperfusion in rats | Journal of Pharmacy and Pharmacology | 2011 | 63 |
| 35 | Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats | Life Sciences | 2014 | 62 |
| 36 | Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies | European Journal of Medicinal Chemistry | 2018 | 60 |
| 37 | In Vitro and In Vivo Evaluation of Proniosomes Containing Celecoxib for Oral Administration | AAPS PharmSciTech | 2010 | 58 |
| 38 | Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes | Journal of Biological Chemistry | 2011 | 57 |
| 39 | Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions | Naunyn-Schmiedeberg's Archives of Pharmacology | 2019 | 57 |
| 40 | In vitroandin vivoeffects of ferulic acid on gastrointestinal motility: Inhibition of cisplatin-induced delay in gastric emptying in rats | World Journal of Gastroenterology | 2006 | 56 |
| 41 | The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other? | Immunological Reviews | 2015 | 54 |
| 42 | Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars | Scientific Reports | 2018 | 54 |
| 43 | Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa | European Journal of Medicinal Chemistry | 2011 | 53 |
| 44 | Successive spectrophotometric resolution as a novel technique for the analysis of ternary mixtures of pharmaceuticals | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | 2014 | 53 |
| 45 | Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling | Human and Experimental Toxicology | 2018 | 53 |
| 46 | Synthesis of new 2-thiouracil-5-sulphonamide derivatives with antibacterial and antifungal activity | Archives of Pharmacal Research | 2005 | 51 |
| 47 | Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts | PLoS ONE | 2019 | 51 |
| 48 | Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations | Bioorganic Chemistry | 2021 | 50 |
| 49 | Preparation and characterization of niosomes containing ribavirin for liver targeting | Drug Delivery | 2010 | 49 |
| 50 | Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas | Scientific Reports | 2020 | 48 |
