5.4(top 5%)
impact factor
755(top 20%)
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29.0K(top 10%)
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83(top 10%)
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5.4(top 5%)
impact factor
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134(top 10%)
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Top Articles

#TitleJournalYearCitations
1A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of actionBiology Direct2006961
2Domain enhanced lookup time accelerated BLASTBiology Direct2012705
3The ancient Virus World and evolution of cellsBiology Direct2006559
4Designing of interferon-gamma inducing MHC class-II bindersBiology Direct2013484
5CAIcal: A combined set of tools to assess codon usage adaptationBiology Direct2008447
6Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomicsBiology Direct2012440
7Transcript length bias in RNA-seq data confounds systems biologyBiology Direct2009422
8Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotesBiology Direct2009390
9Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systemsBiology Direct2011379
10Splign: algorithms for computing spliced alignments with identification of paralogsBiology Direct2008329
11IPC – Isoelectric Point CalculatorBiology Direct2016308
12Origin and evolution of spliceosomal intronsBiology Direct2012292
13The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?Biology Direct2006247
14Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elementsBiology Direct2009232
15Evolution before genesBiology Direct2012225
16Is evolution Darwinian or/and Lamarckian?Biology Direct2009224
17Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regionsBiology Direct2013223
18Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processingBiology Direct2013221
19Exosomal transfer of proteins and RNAs at synapses in the nervous systemBiology Direct2007217
20Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum VerrucomicrobiaBiology Direct2008216
21Component retention in principal component analysis with application to cDNA microarray dataBiology Direct2007214
22The Last Universal Common Ancestor: emergence, constitution and genetic legacy of an elusive forerunnerBiology Direct2008207
23The struggle for life of the genome's selfish architectsBiology Direct2011198
24Rooting the tree of life by transition analysesBiology Direct2006196
25The origins of phagocytosis and eukaryogenesisBiology Direct2009190
26Prokaryotic evolution and the tree of life are two different thingsBiology Direct2009188
27Massive comparative genomic analysis reveals convergent evolution of specialized bacteriaBiology Direct2009187
28The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)aBiology Direct2012183
29Inferring clocks when lacking rocks: the variable rates of molecular evolution in bacteriaBiology Direct2009179
30Long intervals of stasis punctuated by bursts of positive selection in the seasonal evolution of influenza A virusBiology Direct2006176
31On the origin of the translation system and the genetic code in the RNA world by means of natural selection, exaptation, and subfunctionalizationBiology Direct2007173
32Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolutionBiology Direct2010165
33A new rhesus macaque assembly and annotation for next-generation sequencing analysesBiology Direct2014165
34Clusters of orthologous genes for 41 archaeal genomes and implications for evolutionary genomics of archaeaBiology Direct2007164
35PEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residuesBiology Direct2015164
36Including RNA secondary structures improves accuracy and robustness in reconstruction of phylogenetic treesBiology Direct2010154
37Origin and evolution of the peroxisomal proteomeBiology Direct2006152
38Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolutionBiology Direct2007146
39Evolutionary primacy of sodium bioenergeticsBiology Direct2008144
40Updated clusters of orthologous genes for Archaea: a complex ancestor of the Archaea and the byways of horizontal gene transferBiology Direct2012142
41A novel virus genome discovered in an extreme environment suggests recombination between unrelated groups of RNA and DNA virusesBiology Direct2012141
42MEGAN-LR: new algorithms allow accurate binning and easy interactive exploration of metagenomic long reads and contigsBiology Direct2018141
43A horizontal gene transfer at the origin of phenylpropanoid metabolism: a key adaptation of plants to landBiology Direct2009138
44A survey of motif discovery methods in an integrated frameworkBiology Direct2006135
45Evolution of glyoxylate cycle enzymes in Metazoa: evidence of multiple horizontal transfer events and pseudogene formationBiology Direct2006135
46An extension of the coevolution theory of the origin of the genetic codeBiology Direct2008134
47pkaPS: prediction of protein kinase A phosphorylation sites with the simplified kinase-substrate binding modelBiology Direct2007131
48Network dynamics of eukaryotic LTR retroelements beyond phylogenetic treesBiology Direct2009128
49Small but versatile: the extraordinary functional and structural diversity of the β-grasp foldBiology Direct2007127
50Unproductive alternative splicing and nonsense mRNAs: A widespread phenomenon among plant circadian clock genesBiology Direct2012125