| # | Title | Journal | Year | Citations |
|---|
| 1 | Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal | Science Signaling | 2013 | 11,344 |
| 2 | Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis | Science Signaling | 2010 | 1,319 |
| 3 | Signaling mechanisms of the epithelial-mesenchymal transition | Science Signaling | 2014 | 1,257 |
| 4 | Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection | Science Signaling | 2009 | 1,165 |
| 5 | Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor | Science Signaling | 2010 | 1,091 |
| 6 | H 2 S Signals Through Protein S-Sulfhydration | Science Signaling | 2009 | 1,050 |
| 7 | The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis | Science Signaling | 2012 | 1,017 |
| 8 | STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway | Science Signaling | 2012 | 938 |
| 9 | The Plant NADPH Oxidase RBOHD Mediates Rapid Systemic Signaling in Response to Diverse Stimuli | Science Signaling | 2009 | 897 |
| 10 | CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior | Science Signaling | 2009 | 862 |
| 11 | Integration of Oxygen Signaling at the Consensus HRE | Science Signaling | 2005 | 788 |
| 12 | The TRP Superfamily of Cation Channels | Science Signaling | 2005 | 750 |
| 13 | Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease | Science Signaling | 2010 | 660 |
| 14 | The Biotin Switch Method for the Detection of S-Nitrosylated Proteins | Science Signaling | 2001 | 656 |
| 15 | Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth | Science Signaling | 2009 | 632 |
| 16 | Human RAS Superfamily Proteins and Related GTPases | Science Signaling | 2004 | 614 |
| 17 | Spatiotemporal Gene Expression Targeting with the TARGET and Gene-Switch Systems in Drosophila | Science Signaling | 2004 | 595 |
| 18 | Interleukin-1 (IL-1) Pathway | Science Signaling | 2010 | 589 |
| 19 | Role of Distinct NMDA Receptor Subtypes at Central Synapses | Science Signaling | 2004 | 579 |
| 20 | mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells | Science Signaling | 2009 | 569 |
| 21 | Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells | Science Signaling | 2014 | 558 |
| 22 | Distinct Phosphorylation Sites on the β 2 -Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin | Science Signaling | 2011 | 535 |
| 23 | The Pharmacology of mTOR Inhibition | Science Signaling | 2009 | 500 |
| 24 | Specificity, versatility, and control of TGF-β family signaling | Science Signaling | 2019 | 494 |
| 25 | Odor Coding by a Mammalian Receptor Repertoire | Science Signaling | 2009 | 487 |
| 26 | The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris | Science Signaling | 2014 | 486 |
| 27 | Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation | Science Signaling | 2000 | 483 |
| 28 | Plant Receptor-Like Kinase Gene Family: Diversity, Function, and Signaling | Science Signaling | 2001 | 482 |
| 29 | Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size | Science Signaling | 2011 | 477 |
| 30 | Computational Alanine Scanning of Protein-Protein Interfaces | Science Signaling | 2004 | 471 |
| 31 | The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense | Science Signaling | 2003 | 466 |
| 32 | TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway | Science Signaling | 2016 | 453 |
| 33 | Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells | Science Signaling | 2011 | 447 |
| 34 | The Complex and Intriguing Lives of PIP2 with Ion Channels and Transporters | Science Signaling | 2001 | 423 |
| 35 | Apoptotic Cells Activate the “Phoenix Rising” Pathway to Promote Wound Healing and Tissue Regeneration | Science Signaling | 2010 | 423 |
| 36 | Linear Motif Atlas for Phosphorylation-Dependent Signaling | Science Signaling | 2008 | 418 |
| 37 | System-Wide Changes to SUMO Modifications in Response to Heat Shock | Science Signaling | 2009 | 415 |
| 38 | Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation | Science Signaling | 2012 | 411 |
| 39 | Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions | Science Signaling | 2013 | 411 |
| 40 | Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities | Science Signaling | 2008 | 407 |
| 41 | The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis | Science Signaling | 2010 | 407 |
| 42 | TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy | Science Signaling | 2010 | 396 |
| 43 | TGF-β–induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops | Science Signaling | 2014 | 395 |
| 44 | Identification of the miR-106b ~ 25 MicroRNA Cluster as a Proto-Oncogenic PTEN -Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation | Science Signaling | 2010 | 390 |
| 45 | System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation | Science Signaling | 2011 | 389 |
| 46 | H 2 S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response | Science Signaling | 2011 | 387 |
| 47 | Signaling by Gasotransmitters | Science Signaling | 2009 | 381 |
| 48 | The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code" | Science Signaling | 2005 | 379 |
| 49 | PDZ Domain Proteins: Plug and Play! | Science Signaling | 2003 | 374 |
| 50 | Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation | Science Signaling | 2015 | 372 |
