# | Title | Journal | Year | Citations |
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1 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 | Cancer Cell | 2010 | 6,138 |
2 | Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment | Cancer Cell | 2012 | 3,578 |
3 | Tensional homeostasis and the malignant phenotype | Cancer Cell | 2005 | 3,397 |
4 | Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy | Cancer Cell | 2015 | 3,266 |
5 | Integrative Genomic Profiling of Human Prostate Cancer | Cancer Cell | 2010 | 3,151 |
6 | Unique microRNA molecular profiles in lung cancer diagnosis and prognosis | Cancer Cell | 2006 | 2,870 |
7 | A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes | Cancer Cell | 2006 | 2,729 |
8 | Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis | Cancer Cell | 2006 | 2,706 |
9 | Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis | Cancer Cell | 2005 | 2,695 |
10 | Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate | Cancer Cell | 2012 | 2,617 |
11 | Defining the Role of mTOR in Cancer | Cancer Cell | 2007 | 2,610 |
12 | Long Noncoding RNAs in Cancer Pathways | Cancer Cell | 2016 | 2,584 |
13 | Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN | Cancer Cell | 2009 | 2,522 |
14 | Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases | Cancer Cell | 2011 | 2,340 |
15 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation | Cancer Cell | 2010 | 2,328 |
16 | A multigenic program mediating breast cancer metastasis to bone | Cancer Cell | 2003 | 2,325 |
17 | Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis | Cancer Cell | 2009 | 2,168 |
18 | Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse | Cancer Cell | 2003 | 2,150 |
19 | Gene expression correlates of clinical prostate cancer behavior | Cancer Cell | 2002 | 2,144 |
20 | Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice | Cancer Cell | 2005 | 2,137 |
21 | Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma | Cancer Cell | 2010 | 2,078 |
22 | Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines | Cancer Cell | 2006 | 2,056 |
23 | A Perivascular Niche for Brain Tumor Stem Cells | Cancer Cell | 2007 | 1,994 |
24 | Tumor Cell Metabolism: Cancer's Achilles' Heel | Cancer Cell | 2008 | 1,926 |
25 | Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival | Cancer Cell | 2014 | 1,892 |
26 | IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer | Cancer Cell | 2009 | 1,851 |
27 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis | Cancer Cell | 2006 | 1,779 |
28 | Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase | Cancer Cell | 2005 | 1,764 |
29 | Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling | Cancer Cell | 2002 | 1,756 |
30 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate | Cancer Cell | 2010 | 1,754 |
31 | PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients | Cancer Cell | 2004 | 1,693 |
32 | AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients | Cancer Cell | 2007 | 1,675 |
33 | Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma | Cancer Cell | 2012 | 1,664 |
34 | Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis | Cancer Cell | 2009 | 1,624 |
35 | Smoldering and polarized inflammation in the initiation and promotion of malignant disease | Cancer Cell | 2005 | 1,622 |
36 | Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma | Cancer Cell | 2014 | 1,616 |
37 | Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma | Cancer Cell | 2012 | 1,551 |
38 | Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia | Cancer Cell | 2002 | 1,548 |
39 | Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors | Cancer Cell | 2005 | 1,478 |
40 | Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis | Cancer Cell | 2011 | 1,476 |
41 | The RB and p53 pathways in cancer | Cancer Cell | 2002 | 1,473 |
42 | A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer | Cancer Cell | 2007 | 1,471 |
43 | Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics | Cancer Cell | 2002 | 1,467 |
44 | Nuclear factor-κB | Cancer Cell | 2004 | 1,428 |
45 | Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma | Cancer Cell | 2017 | 1,428 |
46 | YAP/TAZ at the Roots of Cancer | Cancer Cell | 2016 | 1,409 |
47 | Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis | Cancer Cell | 2016 | 1,401 |
48 | A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma | Cancer Cell | 2014 | 1,392 |
49 | Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance | Cancer Cell | 2006 | 1,390 |
50 | Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl | Cancer Cell | 2005 | 1,387 |