Synapse

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125.7K(top 5%)

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138(top 5%)

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208(top 5%)

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Top Articles

#	Title	Journal	Year	Citations
1	Differential projections of the infralimbic and prelimbic cortex in the rat	Synapse	2004	1,324
2	Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists	Synapse	1987	841
3	Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers	Synapse	1993	836
4	Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin	Synapse	2001	825
5	Dopamine receptors and the dopamine hypothesis of schizophrenia	Synapse	1987	792
6	Review: D1 dopamine receptor?the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications	Synapse	1987	677
7	Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy	Synapse	1989	586
8	The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory	Synapse	1991	555
9	Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens	Synapse	1990	530
10	Alcohol promotes dopamine release in the human nucleus accumbens	Synapse	2003	482
11	From ion currents to genomic analysis: Recent advances in GABAA receptor research	Synapse	1995	476
12	Noradrenergic mechanisms in stress and anxiety: I. preclinical studies	Synapse	1996	459
13	Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area	Synapse	1994	455
14	Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices	Synapse	1989	427
15	Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: Electrophysiological studies in the rat brain	Synapse	1987	420
16	Dopamine receptor pruning in prefrontal cortex during the periadolescent period in rats	Synapse	2000	418
17	Review: Fine structure of synaptogenesis in the vertebrate central nervous system	Synapse	1989	415
18	Long-Term frontal brain metabolic changes in cocaine abusers	Synapse	1992	402
19	?Nonhedonic? food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect	Synapse	2002	400
20	Human brain dopamine receptors in children and aging adults	Synapse	1987	396
21	The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei	Synapse	1987	391
22	Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex	Synapse	2001	385
23	Imaging endogenous dopamine competition with [11C]raclopride in the human brain	Synapse	1994	362
24	Direct effect of 17?-estradiol on striatum: Sex differences in dopamine release	Synapse	1990	351
25	SPECT imaging of dopamine and serotonin transporters with [123I]?-CIT: Pharmacological characterization of brain uptake in nonhuman primates	Synapse	1993	333
26	Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus	Synapse	1989	324
27	Molecular alterations in the neostriatum of human cocaine addicts	Synapse	1993	323
28	GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex	Synapse	2000	308
29	Amphetamine-Induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: A microdialysis study in behaving rats	Synapse	1995	299
30	Psychosis pathways converge via D2High dopamine receptors	Synapse	2006	298
31	Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex	Synapse	1997	295
32	Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: Implications for positron emission tomography of the human brain	Synapse	1989	292
33	Mapping cocaine binding sites in human and baboon brain in vivo	Synapse	1989	292
34	Serotonin2C receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat	Synapse	2000	290
35	Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels	Synapse	1993	275
36	Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications	Synapse	2002	273
37	Cannabinoid CB2receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study	Synapse	2004	273
38	Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease	Synapse	2001	272
39	Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine	Synapse	1991	270
40	Brain imaging of18F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors	Synapse	2002	260
41	Methamphetamine-induced neurotoxicity: Roles for glutamate and dopamine efflux	Synapse	1994	259
42	Localization of drug reward mechanisms by intracranial injections	Synapse	1992	254
43	Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine	Synapse	1991	249
44	Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period	Synapse	1999	247
45	Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates	Synapse	1997	246
46	Morphine alters the structure of neurons in the nucleus accumbens and neocortex of rats	Synapse	1999	245
47	Long-Term synaptic potentiation in the amygdala	Synapse	1990	244
48	Brain DA D2 receptors predict reinforcing effects of stimulants in humans: Replication study	Synapse	2002	242
49	Pharmacological aspects of excitatory synaptic transmission to second-order vestibular neurons in the frog	Synapse	1987	237
50	Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei	Synapse	1993	235

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