| # | Title | Journal | Year | Citations |
|---|
| 1 | EMBOSS: The European Molecular Biology Open Software Suite | Trends in Genetics | 2000 | 8,136 |
| 2 | The impact of next-generation sequencing technology on genetics | Trends in Genetics | 2008 | 1,848 |
| 3 | Cytosine methylation and the ecology of intragenomic parasites | Trends in Genetics | 1997 | 1,748 |
| 4 | The multistep nature of cancer | Trends in Genetics | 1993 | 1,643 |
| 5 | Metalloproteinases and their inhibitors in matrix remodeling | Trends in Genetics | 1990 | 1,576 |
| 6 | DNA hypermethylation in tumorigenesis: epigenetics joins genetics | Trends in Genetics | 2000 | 1,492 |
| 7 | Ten years of next-generation sequencing technology | Trends in Genetics | 2014 | 1,240 |
| 8 | Role for DNA methylation in genomic imprinting | Trends in Genetics | 1994 | 1,194 |
| 9 | Alternative splicing: increasing diversity in the proteomic world | Trends in Genetics | 2001 | 1,120 |
| 10 | Nuclear receptors enhance our understanding of transcription regulation | Trends in Genetics | 1988 | 1,119 |
| 11 | Human housekeeping genes, revisited | Trends in Genetics | 2013 | 1,091 |
| 12 | On the allelic spectrum of human disease | Trends in Genetics | 2001 | 1,057 |
| 13 | The genes of the Green Revolution | Trends in Genetics | 2003 | 1,020 |
| 14 | Collagens, modifying enzymes and their mutations in humans, flies and worms | Trends in Genetics | 2004 | 989 |
| 15 | From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion | Trends in Genetics | 1993 | 947 |
| 16 | Genomic imprinting in mammalian development: a parental tug-of-war | Trends in Genetics | 1991 | 945 |
| 17 | The Landscape of long noncoding RNA classification | Trends in Genetics | 2015 | 942 |
| 18 | Evolution of the Fgf and Fgfr gene families | Trends in Genetics | 2004 | 941 |
| 19 | The Ka/Ks ratio: diagnosing the form of sequence evolution | Trends in Genetics | 2002 | 939 |
| 20 | DNA barcoding: how it complements taxonomy, molecular phylogenetics and population genetics | Trends in Genetics | 2007 | 934 |
| 21 | Genetical genomics: the added value from segregation | Trends in Genetics | 2001 | 931 |
| 22 | Repbase Update: a database and an electronic journal of repetitive elements | Trends in Genetics | 2000 | 895 |
| 23 | Evolution of the mutation rate | Trends in Genetics | 2010 | 885 |
| 24 | Jaks and Stats in signaling by the cytokine receptor superfamily | Trends in Genetics | 1995 | 883 |
| 25 | Genomic imprinting in mammalian development: a parental tug-of-war | Trends in Genetics | 1991 | 845 |
| 26 | MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings | Trends in Genetics | 2008 | 841 |
| 27 | Genomics of microRNA | Trends in Genetics | 2006 | 835 |
| 28 | The Wnt/Ca2+ pathway | Trends in Genetics | 2000 | 820 |
| 29 | Genomic disorders: structural features of the genome can lead to DNA rearrangements and human disease traits | Trends in Genetics | 1998 | 817 |
| 30 | Genome architecture, rearrangements and genomic disorders | Trends in Genetics | 2002 | 815 |
| 31 | Understanding mechanisms of novel gene expression in polyploids | Trends in Genetics | 2003 | 812 |
| 32 | HMG domain proteins: architectural elements in the assembly of nucleoprotein structures | Trends in Genetics | 1994 | 808 |
| 33 | Mutagenesis by 8-oxoguanine: an enemy within | Trends in Genetics | 1993 | 807 |
| 34 | Extraction of high molecular weight DNA from molluscs | Trends in Genetics | 1993 | 792 |
| 35 | It’s a noisy business! Genetic regulation at the nanomolar scale | Trends in Genetics | 1999 | 791 |
| 36 | The Third Revolution in Sequencing Technology | Trends in Genetics | 2018 | 759 |
| 37 | CpG islands as gene markers in the vertebrate nucleus | Trends in Genetics | 1987 | 743 |
| 38 | The secret life of the hair follicle | Trends in Genetics | 1992 | 713 |
| 39 | The genomics of speciation-with-gene-flow | Trends in Genetics | 2012 | 711 |
| 40 | Eukaryotic transposable elements and genome evolution | Trends in Genetics | 1989 | 708 |
| 41 | Pax 6: mastering eye morphogenesis and eye evolution | Trends in Genetics | 1999 | 706 |
| 42 | The secret life of the hair follicle | Trends in Genetics | 1992 | 701 |
| 43 | Deletional bias and the evolution of bacterial genomes | Trends in Genetics | 2001 | 687 |
| 44 | Historical origins and genetic diversity of wine grapes | Trends in Genetics | 2006 | 683 |
| 45 | Circular RNA Expression: Its Potential Regulation and Function | Trends in Genetics | 2016 | 678 |
| 46 | RNA silencing as a plant immune system against viruses | Trends in Genetics | 2001 | 665 |
| 47 | The diversity of RNA silencing pathways in plants | Trends in Genetics | 2006 | 662 |
| 48 | Lateral Thinking: How Histone Modifications Regulate Gene Expression | Trends in Genetics | 2016 | 661 |
| 49 | Phylogenomics: the beginning of incongruence? | Trends in Genetics | 2006 | 644 |
| 50 | The two-hybrid system: an assay for protein-protein interactions | Trends in Genetics | 1994 | 630 |
