# | Title | Journal | Year | Citations |
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1 | Full-length transcriptome assembly from RNA-Seq data without a reference genome | Nature Biotechnology | 2011 | 17,264 |
2 | Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation | Nature Biotechnology | 2010 | 13,805 |
3 | MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification | Nature Biotechnology | 2008 | 12,966 |
4 | Integrative genomics viewer | Nature Biotechnology | 2011 | 11,708 |
5 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
6 | Integrating single-cell transcriptomic data across different conditions, technologies, and species | Nature Biotechnology | 2018 | 8,878 |
7 | StringTie enables improved reconstruction of a transcriptome from RNA-seq reads | Nature Biotechnology | 2015 | 8,385 |
8 | Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences | Nature Biotechnology | 2013 | 8,049 |
9 | Near-optimal probabilistic RNA-seq quantification | Nature Biotechnology | 2016 | 7,322 |
10 | Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype | Nature Biotechnology | 2019 | 6,567 |
11 | 3D bioprinting of tissues and organs | Nature Biotechnology | 2014 | 5,158 |
12 | Principles of nanoparticle design for overcoming biological barriers to drug delivery | Nature Biotechnology | 2015 | 4,868 |
13 | Quantitative analysis of complex protein mixtures using isotope-coded affinity tags | Nature Biotechnology | 1999 | 4,673 |
14 | The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells | Nature Biotechnology | 2014 | 4,652 |
15 | Large-scale analysis of the yeast proteome by multidimensional protein identification technology | Nature Biotechnology | 2001 | 4,540 |
16 | In vivo cancer targeting and imaging with semiconductor quantum dots | Nature Biotechnology | 2004 | 4,460 |
17 | Spatial reconstruction of single-cell gene expression data | Nature Biotechnology | 2015 | 4,254 |
18 | Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein | Nature Biotechnology | 2004 | 4,135 |
19 | Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering | Nature Biotechnology | 2005 | 4,068 |
20 | Molecular Beacons: Probes that Fluoresce upon Hybridization | Nature Biotechnology | 1996 | 3,956 |
21 | DNA targeting specificity of RNA-guided Cas9 nucleases | Nature Biotechnology | 2013 | 3,953 |
22 | Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples | Nature Biotechnology | 2013 | 3,934 |
23 | Renal clearance of quantum dots | Nature Biotechnology | 2007 | 3,789 |
24 | GREAT improves functional interpretation of cis-regulatory regions | Nature Biotechnology | 2010 | 3,789 |
25 | Next-generation DNA sequencing | Nature Biotechnology | 2008 | 3,609 |
26 | Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes | Nature Biotechnology | 2011 | 3,595 |
27 | Nonlinear magic: multiphoton microscopy in the biosciences | Nature Biotechnology | 2003 | 3,524 |
28 | Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies | Nature Biotechnology | 2006 | 3,490 |
29 | A clearer vision for in vivo imaging | Nature Biotechnology | 2001 | 3,393 |
30 | SignalP 5.0 improves signal peptide predictions using deep neural networks | Nature Biotechnology | 2019 | 3,317 |
31 | Differential analysis of gene regulation at transcript resolution with RNA-seq | Nature Biotechnology | 2013 | 3,256 |
32 | Dimensionality reduction for visualizing single-cell data using UMAP | Nature Biotechnology | 2019 | 3,254 |
33 | What is flux balance analysis? | Nature Biotechnology | 2010 | 3,233 |
34 | Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 | Nature Biotechnology | 2016 | 3,168 |
35 | An economic method for the fluorescent labeling of PCR fragments | Nature Biotechnology | 2000 | 3,083 |
36 | Fabrication of novel biomaterials through molecular self-assembly | Nature Biotechnology | 2003 | 3,048 |
37 | Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling | Nature Biotechnology | 2009 | 3,047 |
38 | Expression monitoring by hybridization to high-density oligonucleotide arrays | Nature Biotechnology | 1996 | 3,041 |
39 | The use of nanocrystals in biological detection | Nature Biotechnology | 2004 | 2,849 |
40 | Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking | Nature Biotechnology | 2016 | 2,802 |
41 | A cross-platform toolkit for mass spectrometry and proteomics | Nature Biotechnology | 2012 | 2,794 |
42 | High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells | Nature Biotechnology | 2013 | 2,754 |
43 | Assembly of long, error-prone reads using repeat graphs | Nature Biotechnology | 2019 | 2,730 |
44 | What is a support vector machine? | Nature Biotechnology | 2006 | 2,669 |
45 | CRISPR-Cas systems for editing, regulating and targeting genomes | Nature Biotechnology | 2014 | 2,648 |
46 | Efficient genome editing in zebrafish using a CRISPR-Cas system | Nature Biotechnology | 2013 | 2,638 |
47 | PICRUSt2 for prediction of metagenome functions | Nature Biotechnology | 2020 | 2,621 |
48 | A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life | Nature Biotechnology | 2018 | 2,615 |
49 | Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts | Nature Biotechnology | 2008 | 2,583 |
50 | Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro | Nature Biotechnology | 2000 | 2,554 |