| # | Title | Journal | Year | Citations |
|---|
| 1 | Hallmarks of Cancer: The Next Generation | Cell | 2011 | 52,242 |
| 2 | MicroRNAs | Cell | 2004 | 32,446 |
| 3 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
| 4 | Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors | Cell | 2006 | 22,649 |
| 5 | Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors | Cell | 2007 | 17,969 |
| 6 | MicroRNAs: Target Recognition and Regulatory Functions | Cell | 2009 | 17,802 |
| 7 | SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor | Cell | 2020 | 16,161 |
| 8 | Matrix Elasticity Directs Stem Cell Lineage Specification | Cell | 2006 | 11,769 |
| 9 | The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 | Cell | 1993 | 11,149 |
| 10 | The Hallmarks of Aging | Cell | 2013 | 10,992 |
| 11 | Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets | Cell | 2005 | 10,880 |
| 12 | A genetic model for colorectal tumorigenesis | Cell | 1990 | 10,831 |
| 13 | Pathogen Recognition and Innate Immunity | Cell | 2006 | 9,878 |
| 14 | Integrins: Versatility, modulation, and signaling in cell adhesion | Cell | 1992 | 9,858 |
| 15 | Comprehensive Integration of Single-Cell Data | Cell | 2019 | 9,755 |
| 16 | Chromatin Modifications and Their Function | Cell | 2007 | 9,258 |
| 17 | Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death | Cell | 2012 | 9,007 |
| 18 | Epithelial-Mesenchymal Transitions in Development and Disease | Cell | 2009 | 8,592 |
| 19 | Immunity, Inflammation, and Cancer | Cell | 2010 | 8,516 |
| 20 | WAF1, a potential mediator of p53 tumor suppression | Cell | 1993 | 8,091 |
| 21 | A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes | Cell | 1993 | 7,960 |
| 22 | Integrins | Cell | 2002 | 7,714 |
| 23 | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells | Cell | 2008 | 7,695 |
| 24 | mTOR Signaling in Growth Control and Disease | Cell | 2012 | 7,066 |
| 25 | p53, the Cellular Gatekeeper for Growth and Division | Cell | 1997 | 7,028 |
| 26 | Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein | Cell | 2020 | 6,979 |
| 27 | Pattern Recognition Receptors and Inflammation | Cell | 2010 | 6,978 |
| 28 | Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm | Cell | 1994 | 6,758 |
| 29 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade | Cell | 1997 | 6,625 |
| 30 | A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping | Cell | 2014 | 6,520 |
| 31 | The nuclear receptor superfamily: The second decade | Cell | 1995 | 6,478 |
| 32 | Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis | Cell | 1996 | 6,230 |
| 33 | Autophagy in the Pathogenesis of Disease | Cell | 2008 | 6,190 |
| 34 | High-Resolution Profiling of Histone Methylations in the Human Genome | Cell | 2007 | 6,036 |
| 35 | A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? | Cell | 2011 | 5,954 |
| 36 | Integrated analysis of multimodal single-cell data | Cell | 2021 | 5,912 |
| 37 | Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets | Cell | 2015 | 5,908 |
| 38 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor | Cell | 1999 | 5,895 |
| 39 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death | Cell | 1993 | 5,865 |
| 40 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases | Cell | 1993 | 5,487 |
| 41 | Signal transduction by receptors with tyrosine kinase activity | Cell | 1990 | 5,482 |
| 42 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus | Cell | 2003 | 5,290 |
| 43 | AKT/PKB Signaling: Navigating Downstream | Cell | 2007 | 5,261 |
| 44 | The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells | Cell | 1982 | 5,223 |
| 45 | Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery | Cell | 1997 | 5,212 |
| 46 | DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development | Cell | 1999 | 5,204 |
| 47 | TOR Signaling in Growth and Metabolism | Cell | 2006 | 5,202 |
| 48 | Wnt/β-Catenin Signaling in Development and Disease | Cell | 2006 | 4,999 |
| 49 | Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior | Cell | 1998 | 4,993 |
| 50 | Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes | Cell | 1986 | 4,959 |
