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Top Articles

#TitleJournalYearCitations
1DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences of the United States of America197768,426
2Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences of the United States of America197952,015
3Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profilesProceedings of the National Academy of Sciences of the United States of America200538,922
4Neural networks and physical systems with emergent collective computational abilities.Proceedings of the National Academy of Sciences of the United States of America198215,174
5Cluster analysis and display of genome-wide expression patternsProceedings of the National Academy of Sciences of the United States of America199814,487
6One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR productsProceedings of the National Academy of Sciences of the United States of America200013,843
7Community structure in social and biological networksProceedings of the National Academy of Sciences of the United States of America200211,888
8Improved tools for biological sequence comparison.Proceedings of the National Academy of Sciences of the United States of America198810,937
9Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences of the United States of America200110,626
10A default mode of brain functionProceedings of the National Academy of Sciences of the United States of America200110,607
11Two-dimensional atomic crystalsProceedings of the National Academy of Sciences of the United States of America200510,229
12Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences of the United States of America20019,721
13Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences of the United States of America20039,314
14Modularity and community structure in networksProceedings of the National Academy of Sciences of the United States of America20069,017
15Statistical significance for genomewide studiesProceedings of the National Academy of Sciences of the United States of America20038,800
16Mathematical model for studying genetic variation in terms of restriction endonucleases.Proceedings of the National Academy of Sciences of the United States of America19798,677
17Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.Proceedings of the National Academy of Sciences of the United States of America19808,637
18Genomic sequencing.Proceedings of the National Academy of Sciences of the United States of America19848,043
19A new method for sequencing DNA.Proceedings of the National Academy of Sciences of the United States of America19777,987
20An index to quantify an individual's scientific research outputProceedings of the National Academy of Sciences of the United States of America20057,912
21Analysis of Gene Diversity in Subdivided PopulationsProceedings of the National Academy of Sciences of the United States of America19737,553
22From The Cover: The human brain is intrinsically organized into dynamic, anticorrelated functional networksProceedings of the National Academy of Sciences of the United States of America20057,496
23Global patterns of 16S rRNA diversity at a depth of millions of sequences per sampleProceedings of the National Academy of Sciences of the United States of America20117,425
24Powering the planet: Chemical challenges in solar energy utilizationProceedings of the National Academy of Sciences of the United States of America20067,148
25Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-CelluloseProceedings of the National Academy of Sciences of the United States of America19727,134
26Circulating microRNAs as stable blood-based markers for cancer detectionProceedings of the National Academy of Sciences of the United States of America20087,047
27The Compressibility of Media under Extreme PressuresProceedings of the National Academy of Sciences of the United States of America19447,006
28Rapid and efficient site-specific mutagenesis without phenotypic selection.Proceedings of the National Academy of Sciences of the United States of America19856,825
29Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.Proceedings of the National Academy of Sciences of the United States of America19906,663
30Electrostatics of nanosystems: Application to microtubules and the ribosomeProceedings of the National Academy of Sciences of the United States of America20016,623
31Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences of the United States of America19716,403
32A biomarker that identifies senescent human cells in culture and in aging skin in vivo.Proceedings of the National Academy of Sciences of the United States of America19956,376
33Exceptional chemical and thermal stability of zeolitic imidazolate frameworksProceedings of the National Academy of Sciences of the United States of America20065,906
34Neurons with graded response have collective computational properties like those of two-state neurons.Proceedings of the National Academy of Sciences of the United States of America19845,898
35A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.Proceedings of the National Academy of Sciences of the United States of America19955,897
36Functional connectivity in the resting brain: A network analysis of the default mode hypothesisProceedings of the National Academy of Sciences of the United States of America20035,651
37Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya.Proceedings of the National Academy of Sciences of the United States of America19905,500
38Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.Proceedings of the National Academy of Sciences of the United States of America19955,469
39Equilibrium points in n-person gamesProceedings of the National Academy of Sciences of the United States of America19505,432
40Oxidants, antioxidants, and the degenerative diseases of aging.Proceedings of the National Academy of Sciences of the United States of America19935,290
41Brain magnetic resonance imaging with contrast dependent on blood oxygenation.Proceedings of the National Academy of Sciences of the United States of America19905,253
42Obesity alters gut microbial ecologyProceedings of the National Academy of Sciences of the United States of America20055,247
43Shifting the genomic gold standard for the prokaryotic species definitionProceedings of the National Academy of Sciences of the United States of America20095,234
44Amino acid substitution matrices from protein blocks.Proceedings of the National Academy of Sciences of the United States of America19925,230
45Nobel Lecture: PrionsProceedings of the National Academy of Sciences of the United States of America19985,225
46A microRNA expression signature of human solid tumors defines cancer gene targetsProceedings of the National Academy of Sciences of the United States of America20065,220
47Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.Proceedings of the National Academy of Sciences of the United States of America19765,160
48Global food demand and the sustainable intensification of agricultureProceedings of the National Academy of Sciences of the United States of America20115,160
49Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.Proceedings of the National Academy of Sciences of the United States of America19965,156
50The gut microbiota as an environmental factor that regulates fat storageProceedings of the National Academy of Sciences of the United States of America20045,131