| # | Title | Journal | Year | Citations |
|---|
| 1 | Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Nature | 1970 | 253,557 |
| 2 | Deep learning | Nature | 2015 | 52,813 |
| 3 | Helical microtubules of graphitic carbon | Nature | 1991 | 39,105 |
| 4 | Collective dynamics of ‘small-world’ networks | Nature | 1998 | 34,143 |
| 5 | Electrochemical Photolysis of Water at a Semiconductor Electrode | Nature | 1972 | 28,828 |
| 6 | A low-cost, high-efficiency solar cell based on dye-sensitized colloidal TiO2 films | Nature | 1991 | 26,665 |
| 7 | Biodiversity hotspots for conservation priorities | Nature | 2000 | 22,192 |
| 8 | Initial sequencing and analysis of the human genome | Nature | 2001 | 21,074 |
| 9 | Learning representations by back-propagating errors | Nature | 1986 | 19,202 |
| 10 | Two-dimensional gas of massless Dirac fermions in graphene | Nature | 2005 | 18,948 |
| 11 | Highly accurate protein structure prediction with AlphaFold | Nature | 2021 | 17,754 |
| 12 | Issues and challenges facing rechargeable lithium batteries | Nature | 2001 | 17,629 |
| 13 | A pneumonia outbreak associated with a new coronavirus of probable bat origin | Nature | 2020 | 17,004 |
| 14 | Continuous cultures of fused cells secreting antibody of predefined specificity | Nature | 1975 | 16,707 |
| 15 | Building better batteries | Nature | 2008 | 16,547 |
| 16 | Human-level control through deep reinforcement learning | Nature | 2015 | 15,934 |
| 17 | An integrated encyclopedia of DNA elements in the human genome | Nature | 2012 | 15,516 |
| 18 | Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism | Nature | 1992 | 15,429 |
| 19 | The value of the world's ecosystem services and natural capital | Nature | 1997 | 15,321 |
| 20 | C60: Buckminsterfullerene | Nature | 1985 | 14,587 |
| 21 | A global reference for human genetic variation | Nature | 2015 | 13,998 |
| 22 | Molecular portraits of human breast tumours | Nature | 2000 | 13,397 |
| 23 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans | Nature | 1998 | 13,137 |
| 24 | Dendritic cells and the control of immunity | Nature | 1998 | 13,114 |
| 25 | Inflammation and cancer | Nature | 2002 | 12,666 |
| 26 | Positional cloning of the mouse obese gene and its human homologue | Nature | 1994 | 12,218 |
| 27 | Experimental observation of the quantum Hall effect and Berry's phase in graphene | Nature | 2005 | 12,153 |
| 28 | Photoelectrochemical cells | Nature | 2001 | 11,931 |
| 29 | Graphene-based composite materials | Nature | 2006 | 11,655 |
| 30 | Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid | Nature | 1953 | 11,205 |
| 31 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine | Nature | 1980 | 11,108 |
| 32 | Light-emitting diodes based on conjugated polymers | Nature | 1990 | 10,985 |
| 33 | The plant immune system | Nature | 2006 | 10,939 |
| 34 | Learning the parts of objects by non-negative matrix factorization | Nature | 1999 | 10,768 |
| 35 | A synaptic model of memory: long-term potentiation in the hippocampus | Nature | 1993 | 10,699 |
| 36 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells | Nature | 1988 | 10,647 |
| 37 | Surface plasmon subwavelength optics | Nature | 2003 | 10,571 |
| 38 | Comprehensive molecular portraits of human breast tumours | Nature | 2012 | 10,282 |
| 39 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor | Nature | 1987 | 10,262 |
| 40 | The pathogenesis of atherosclerosis: a perspective for the 1990s | Nature | 1993 | 10,206 |
| 41 | Array programming with NumPy | Nature | 2020 | 10,143 |
| 42 | An obesity-associated gut microbiome with increased capacity for energy harvest | Nature | 2006 | 10,136 |
| 43 | The functions of animal microRNAs | Nature | 2004 | 9,846 |
| 44 | Mastering the game of Go with deep neural networks and tree search | Nature | 2016 | 9,796 |
| 45 | Large-scale pattern growth of graphene films for stretchable transparent electrodes | Nature | 2009 | 9,624 |
| 46 | Structure, function and diversity of the healthy human microbiome | Nature | 2012 | 9,614 |
| 47 | Mutations of the BRAF gene in human cancer | Nature | 2002 | 9,374 |
| 48 | A new coronavirus associated with human respiratory disease in China | Nature | 2020 | 9,370 |
| 49 | The missing memristor found | Nature | 2008 | 9,354 |
| 50 | A human gut microbial gene catalogue established by metagenomic sequencing | Nature | 2010 | 9,342 |
