| # | Title | Journal | Year | Citations |
|---|
| 1 | The Lancet Commission on global mental health and sustainable development | Lancet, The | 2018 | 1,534 |
| 2 | M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination | Nature Neuroscience | 2013 | 1,357 |
| 3 | Nature and mental health: An ecosystem service perspective | Science Advances | 2019 | 899 |
| 4 | Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility | Nature Genetics | 2011 | 778 |
| 5 | Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity | Biological Psychiatry | 2009 | 629 |
| 6 | Distinct routes of lineage development reshape the human blood hierarchy across ontogeny | Science | 2016 | 597 |
| 7 | A high-resolution survey of deletion polymorphism in the human genome | Nature Genetics | 2006 | 595 |
| 8 | Chromosome 21 and Down syndrome: from genomics to pathophysiology | Nature Reviews Genetics | 2004 | 582 |
| 9 | Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial | Lancet, The | 2010 | 556 |
| 10 | Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation | Nature Protocols | 2016 | 527 |
| 11 | Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei | Nature Reviews Microbiology | 2006 | 526 |
| 12 | Common genetic variation drives molecular heterogeneity in human iPSCs | Nature | 2017 | 491 |
| 13 | A role for Dicer in immune regulation | Journal of Experimental Medicine | 2006 | 490 |
| 14 | Antimicrobial resistance in humans, livestock and the wider environment | Philosophical Transactions of the Royal Society B: Biological Sciences | 2015 | 461 |
| 15 | Active Inference, homeostatic regulation and adaptive behavioural control | Progress in Neurobiology | 2015 | 458 |
| 16 | Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK | Nature Medicine | 2021 | 450 |
| 17 | Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations | PLoS Genetics | 2010 | 434 |
| 18 | Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes | Stem Cells | 2010 | 385 |
| 19 | Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants | Nature Biotechnology | 2011 | 384 |
| 20 | Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients | Clinical Infectious Diseases | 2017 | 381 |
| 21 | Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke | Nature Genetics | 2012 | 375 |
| 22 | Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury | Cell Stem Cell | 2013 | 329 |
| 23 | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals | Nature Genetics | 2019 | 328 |
| 24 | Beyond authorship: attribution, contribution, collaboration, and credit | Learned Publishing | 2015 | 319 |
| 25 | Genome editing reveals a role for OCT4 in human embryogenesis | Nature | 2017 | 315 |
| 26 | Trait Variation in Yeast Is Defined by Population History | PLoS Genetics | 2011 | 311 |
| 27 | Vesicular Glutamate Transporter 3 Is Required for Synaptic Transmission in Zebrafish Hair Cells | Journal of Neuroscience | 2008 | 292 |
| 28 | Time for united action on depression: a Lancet–World Psychiatric Association Commission | Lancet, The | 2022 | 292 |
| 29 | Neural Origins of Human Sickness in Interoceptive Responses to Inflammation | Biological Psychiatry | 2009 | 290 |
| 30 | Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency | Genes and Development | 2010 | 287 |
| 31 | DNA methylation dynamics during the mammalian life cycle | Philosophical Transactions of the Royal Society B: Biological Sciences | 2013 | 262 |
| 32 | Impact of vaccination on new SARS-CoV-2 infections in the United Kingdom | Nature Medicine | 2021 | 260 |
| 33 | Building a tuberculosis-free world: The Lancet Commission on tuberculosis | Lancet, The | 2019 | 257 |
| 34 | Sepsis in Intensive Care Unit Patients: Worldwide Data From the Intensive Care over Nations Audit | Open Forum Infectious Diseases | 2018 | 255 |
| 35 | Salmonella enterica Serovar Typhi and the Pathogenesis of Typhoid Fever | Annual Review of Microbiology | 2014 | 254 |
| 36 | Antibody responses to SARS-CoV-2 vaccines in 45,965 adults from the general population of the United Kingdom | Nature Microbiology | 2021 | 254 |
| 37 | A phenylethylamine oxidising defect in migraine | Nature | 1974 | 252 |
| 38 | ISA software suite: supporting standards-compliant experimental annotation and enabling curation at the community level | Bioinformatics | 2010 | 247 |
| 39 | The topography of mutational processes in breast cancer genomes | Nature Communications | 2016 | 235 |
| 40 | Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants | Nature | 1987 | 221 |
| 41 | Use of serological surveys to generate key insights into the changing global landscape of infectious disease | Lancet, The | 2016 | 213 |
| 42 | Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years | Science | 2020 | 210 |
| 43 | Sharing research data to improve public health | Lancet, The | 2011 | 208 |
| 44 | A Strand-Specific RNA–Seq Analysis of the Transcriptome of the Typhoid Bacillus Salmonella Typhi | PLoS Genetics | 2009 | 202 |
| 45 | Robust, Persistent Transgene Expression in Human Embryonic Stem Cells Is Achieved with AAVS1-Targeted Integration | Stem Cells | 2008 | 200 |
| 46 | The Hong Kong Principles for assessing researchers: Fostering research integrity | PLoS Biology | 2020 | 200 |
| 47 | Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens | PLoS Pathogens | 2009 | 197 |
| 48 | Genetic regulatory signatures underlying islet gene expression and type 2 diabetes | Proceedings of the National Academy of Sciences of the United States of America | 2017 | 189 |
| 49 | Publishing: Credit where credit is due | Nature | 2014 | 189 |
| 50 | Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes | Science | 2021 | 185 |
