749(top 15%)
63.2K(top 7%)
163(top 13%)
★★ articles
99(top 3%)
★★★ articles
5.8(top 2%)
Avg IF
89(top 8%)
243(top 4%)

Most Cited Articles of Wellcome Trust in 2000

The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequencesNature20001.6K
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491Nature2000649
A role for Saccharomyces cerevisiae histone H2A in DNA repairNature2000526
Mutations truncating the EP300 acetylase in human cancersNature Genetics2000482
Latrunculin alters the actin-monomer subunit interface to prevent polymerizationNature Cell Biology2000387
1 alpha,25-dihydroxyvitamin D(3) inhibits angiogenesis in vitro and in vivoCirculation Research2000350
Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malariaNature Medicine2000251
Generation of superhelical torsion by ATP-dependent chromatin remodeling activitiesCell2000233
Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesvirusesProceedings of the National Academy of Sciences of the United States of America2000187
Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational diseaseProtein Science2000162
Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamilyJournal of Biological Chemistry2000152
Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditionsJournal of Gastroenterology and Hepatology (Australia)2000146
The structure of reduced tryparedoxin peroxidase reveals a decamer and insight into reactivity of 2Cys-peroxiredoxinsJournal of Molecular Biology2000143
The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137Immunity2000143
Phage therapy: the peculiar kinetics of self-replicating pharmaceuticalsClinical Pharmacology and Therapeutics2000137
Butyrate and glucose metabolism by colonocytes in experimental colitis in miceGut2000116
Pathogenic alpha 1-antitrypsin polymers are formed by reactive loop-beta-sheet A linkageJournal of Biological Chemistry2000114
Evaluating "payback" on biomedical research from papers cited in clinical guidelines: applied bibliometric studyBMJ: British Medical Journal2000108
Microtubules switch occasionally into unfavorable configurations during elongationJournal of Molecular Biology2000107
Retinoschisin, the X-linked retinoschisis protein, is a secreted photoreceptor protein, and is expressed and released by Weri-Rb1 cellsHuman Molecular Genetics2000106
Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivationGenes and Development2000102
Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaksCurrent Biology200089
Do intestinal nematodes affect productivity in adulthood?Parasitology Today200078
Characterization of mucins from cultured normal human tracheobronchial epithelial cellsAmerican Journal of Physiology - Lung Cellular and Molecular Physiology200071
Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretionsBiochemical Journal200068