| # | Title | Journal | Year | Citations |
|---|
| 1 | Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome | Science | 2006 | 5,356 |
| 2 | ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation | European Heart Journal | 2012 | 5,034 |
| 3 | 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides | Arthritis and Rheumatism | 2013 | 4,839 |
| 4 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease | European Heart Journal | 2003 | 2,808 |
| 7 | Mutations in PCSK9 cause autosomal dominant hypercholesterolemia | Nature Genetics | 2003 | 2,532 |
| 8 | Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients | Science | 2020 | 2,374 |
| 9 | 2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative | Arthritis and Rheumatism | 2013 | 2,359 |
| 10 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,292 |
| 11 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 12 | Extending the CONSORT Statement to Randomized Trials of Nonpharmacologic Treatment: Explanation and Elaboration | Annals of Internal Medicine | 2008 | 1,865 |
| 13 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
| 14 | 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative | Annals of the Rheumatic Diseases | 2013 | 1,705 |
| 15 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update | Annals of the Rheumatic Diseases | 2014 | 1,688 |
| 16 | Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors | JAMA Oncology | 2018 | 1,625 |
| 17 | A molecular marker of artemisinin-resistant Plasmodium falciparum malaria | Nature | 2014 | 1,617 |
| 18 | EAU Guidelines on Non–Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016 | European Urology | 2017 | 1,594 |
| 19 | International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study | Lancet, The | 2018 | 1,487 |
| 20 | Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium | Clinical Infectious Diseases | 2020 | 1,429 |
| 21 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 22 | Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2017 | 1,376 |
| 23 | European guideline for the diagnosis and treatment of insomnia | Journal of Sleep Research | 2017 | 1,334 |
| 24 | STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration | BMJ Open | 2016 | 1,324 |
| 25 | Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria | Alzheimer's and Dementia | 2016 | 1,318 |
| 26 | Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease | Hypertension | 2001 | 1,284 |
| 27 | Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C | Hepatology | 2005 | 1,276 |
| 28 | Using and Reporting the Delphi Method for Selecting Healthcare Quality Indicators: A Systematic Review | PLoS ONE | 2011 | 1,259 |
| 29 | Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine | Intensive Care Medicine | 2014 | 1,240 |
| 30 | Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma | Nature Genetics | 2012 | 1,229 |
| 31 | Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia | Nature | 2010 | 1,153 |
| 32 | Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults | JAMA - Journal of the American Medical Association | 2003 | 1,149 |
| 33 | 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus | Arthritis and Rheumatology | 2019 | 1,098 |
| 34 | The burden of liver disease in Europe: A review of available epidemiological data | Journal of Hepatology | 2013 | 1,089 |
| 35 | Language‐specific tuning of visual cortex? Functional properties of the Visual Word Form Area | Brain | 2002 | 1,085 |
| 36 | Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies | Annals of the Rheumatic Diseases | 2006 | 1,041 |
| 37 | Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension | Circulation | 2005 | 1,040 |
| 38 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study | Lancet, The | 2009 | 996 |
| 39 | Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial | Lancet, The | 2009 | 995 |
| 40 | Potential of fecal microbiota for early‐stage detection of colorectal cancer | Molecular Systems Biology | 2014 | 991 |
| 41 | Causal relation between α-synuclein locus duplication as a cause of familial Parkinson's disease | Lancet, The | 2004 | 987 |
| 42 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 43 | Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery? | European Heart Journal | 2005 | 966 |
| 44 | ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents | Journal of Pediatric Gastroenterology and Nutrition | 2014 | 961 |
| 45 | Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial | Lancet, The | 2011 | 957 |
| 46 | Immune infiltration in human tumors: a prognostic factor that should not be ignored | Oncogene | 2010 | 942 |
| 47 | Non-invasive assessment of intracranial pressure using ocular sonography in neurocritical care patients | Intensive Care Medicine | 2008 | 927 |
| 48 | Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection | JAMA Pediatrics | 2021 | 910 |
| 49 | Guidelines on Male Sexual Dysfunction: Erectile Dysfunction and Premature Ejaculation | European Urology | 2010 | 905 |
| 50 | Practices of Liver Biopsy in France: Results of a Prospective Nationwide Survey | Hepatology | 2000 | 897 |
