| Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations | Journal of Pain | 2008 | 2K |
| Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration | Annals of Internal Medicine | 2008 | 1.5K |
| T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma | Immunity | 2008 | 1.3K |
| Genes mirror geography within Europe | Nature | 2008 | 1K |
| Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages | Immunity | 2008 | 931 |
| Sexual problems and distress in United States women: prevalence and correlates | Obstetrics and Gynecology | 2008 | 927 |
| Molecular antagonism and plasticity of regulatory and inflammatory T cell programs | Immunity | 2008 | 895 |
| Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways | Journal of Alzheimer's Disease | 2008 | 717 |
| ApoE promotes the proteolytic degradation of Abeta | Neuron | 2008 | 680 |
| Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study | American Journal of Respiratory and Critical Care Medicine | 2008 | 566 |
| Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression | Trends in Immunology | 2008 | 544 |
| BMP type I receptor inhibition reduces heterotopic [corrected] ossification | Nature Medicine | 2008 | 487 |
| Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) | European Respiratory Journal | 2008 | 486 |
| BMI-related errors in the measurement of obesity | International Journal of Obesity | 2008 | 482 |
| Toxicology. Transforming environmental health protection | Science | 2008 | 478 |
| Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease | Journal of Hepatology | 2008 | 473 |
| Modeling targeted layered containment of an influenza pandemic in the United States | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 462 |
| Oxidative stress, DNA methylation and carcinogenesis | Cancer Letters | 2008 | 456 |
| Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells | Molecular and Cellular Biology | 2008 | 424 |
| Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project | Nature Biotechnology | 2008 | 417 |
| Development of a digital microfluidic platform for point of care testing | Lab on A Chip | 2008 | 407 |
| Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking | Molecular Psychiatry | 2008 | 402 |
| Season, sex, age, and education as modifiers of the effects of outdoor air pollution on daily mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study | Environmental Health Perspectives | 2008 | 396 |
| The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases | Cell Research | 2008 | 382 |
| Is glycemic control improving in U.S. adults? | Diabetes Care | 2008 | 379 |
