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Most Cited Articles of Research Triangle Park Foundation in 2000

Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testingEnvironmental and Molecular Mutagenesis20003.5K
A note on robust variance estimation for cluster-correlated dataBiometrics20001.8K
The PPARs: from orphan receptors to drug discoveryJournal of Medicinal Chemistry20001.6K
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesisMolecular Cell20001.5K
The Ames Salmonella/microsome mutagenicity assayMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis20001.3K
Association of fine particulate matter from different sources with daily mortality in six U.S. citiesEnvironmental Health Perspectives2000936
The transcriptome of Arabidopsis thaliana during systemic acquired resistanceNature Genetics2000829
Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male ratToxicological Sciences2000801
DNA replication fidelityAnnual Review of Biochemistry2000788
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cellsArchives of Toxicology2000787
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptorProceedings of the National Academy of Sciences of the United States of America2000763
Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microgliaJournal of Neuroscience2000716
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligandsJournal of Biological Chemistry2000660
Cadmium carcinogenesis in reviewJournal of Inorganic Biochemistry2000654
Convolution PML (CPML): An efficient FDTD implementation of the CFS–PML for arbitrary mediaMicrowave and Optical Technology Letters2000618
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's diseaseProceedings of the National Academy of Sciences of the United States of America2000610
The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male ratToxicological Sciences2000569
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolutionMolecular Endocrinology2000565
Adaptive image contrast enhancement using generalizations of histogram equalizationIEEE Transactions on Image Processing2000565
A test for linkage and association in general pedigrees: the pedigree disequilibrium testAmerican Journal of Human Genetics2000562
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical SafetyMutation Research - Reviews in Mutation Research2000536
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptorsMolecular Cell2000503
Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposityJournal of Biological Chemistry2000470
Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trialLancet, The2000470
Biogenic Hydrocarbons in the Atmospheric Boundary Layer: A ReviewBulletin of the American Meteorological Society2000462