Institute for Molecular Medicine Finland

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Top Articles

#	Title	Journal	Year	Citations
1	FINEMAP: efficient variable selection using summary data from genome-wide association studies	Bioinformatics	2016	584
2	SynergyFinder: a web application for analyzing drug combination dose–response matrix data	Bioinformatics	2017	403
3	FTO genotype is associated with phenotypic variability of body mass index	Nature	2012	383
4	Genetics of 35 blood and urine biomarkers in the UK Biobank	Nature Genetics	2021	377
5	Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis	Nature Genetics	2013	339
6	Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis	PLoS Genetics	2009	300
7	Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers	Nature Medicine	2020	281
8	Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies	Scientific Reports	2014	243
9	Functionally informed fine-mapping and polygenic localization of complex trait heritability	Nature Genetics	2020	185
10	Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles	Journal of Extracellular Vesicles	2021	182
11	Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes	Theranostics	2017	167
12	metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis	Bioinformatics	2016	138
13	Phenome-wide association studies across large population cohorts support drug target validation	Nature Communications	2018	134
14	Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis	Scientific Reports	2017	120
15	Identification of tumor epithelium and stroma in tissue microarrays using texture analysis	Diagnostic Pathology	2012	119
16	Association of tamoxifen resistance and lipid reprogramming in breast cancer	BMC Cancer	2018	113
17	Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion	Oncogene	2012	112
18	Mutation Update: The Spectra of Nebulin Variants and Associated Myopathies	Human Mutation	2014	107
19	Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum	American Journal of Human Genetics	2018	102
20	Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells	Nature	2020	101
21	The role of polygenic risk and susceptibility genes in breast cancer over the course of life	Nature Communications	2020	101
22	A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury	Nature Communications	2017	99
23	A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales	Translational Psychiatry	2012	98
24	Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices	Scientific Reports	2015	98
25	Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits	PLoS Genetics	2020	95
26	Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib	Cancer Letters	2018	93
27	A combined analysis of genome-wide association studies in breast cancer	Breast Cancer Research and Treatment	2011	90
28	Assessing allele-specific expression across multiple tissues from RNA-seq read data	Bioinformatics	2015	90
29	Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging	Genome Biology	2021	90
30	Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism	Antiviral Research	2017	88
31	Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability	Nature Communications	2021	87
32	Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health	European Respiratory Journal	2021	85
33	Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis	Nature Communications	2017	83
34	Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection	Journal of Biological Chemistry	2012	80
35	Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence	Molecular Psychiatry	2018	80
36	Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits	Nature Communications	2020	80
37	The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer	European Journal of Cancer	2009	79
38	Cancer stem cell drugs target K-ras signaling in a stemness context	Oncogene	2016	78
39	A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity	Human Molecular Genetics	2019	76
40	Emerging cellular targets for influenza antiviral agents	Trends in Pharmacological Sciences	2012	75
41	Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling	Leukemia	2018	75
42	Whole genome association scan for genetic polymorphisms influencing information processing speed	Biological Psychology	2011	70
43	Leveraging European infrastructures to access 1 million human genomes by 2022	Nature Reviews Genetics	2019	69
44	Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity	Clinical Cancer Research	2020	68
45	Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects	Nature Communications	2020	63
46	Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci	Nature Communications	2022	63
47	Clonal hematopoiesis in patients with rheumatoid arthritis	Blood Cancer Journal	2018	62
48	Analysis of Detailed Phenotype Profiles Reveals CHRNA5-CHRNA3-CHRNB4 Gene Cluster Association With Several Nicotine Dependence Traits	Nicotine and Tobacco Research	2012	61
49	A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis	European Journal of Human Genetics	2010	60
50	Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom	European Journal of Human Genetics	2017	60

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