| # | Title | Journal | Year | Citations |
|---|
| 1 | HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy | Science | 1989 | 1,631 |
| 2 | EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS? | Lancet, The | 1978 | 1,494 |
| 3 | Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation | Journal of Molecular Biology | 1995 | 1,462 |
| 4 | Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT) | Science | 1989 | 1,226 |
| 5 | Immunisation against heterologous type II collagen induces arthritis in mice | Nature | 1980 | 974 |
| 6 | Foreign gene expression in yeast: a review | Yeast | 1992 | 948 |
| 7 | Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation | Nature | 1979 | 903 |
| 8 | Immunohistochemical localization of enkephalin in rat brain and spinal cord | Journal of Comparative Neurology | 1978 | 818 |
| 9 | Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase | Science | 1991 | 779 |
| 10 | Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy | Science | 1995 | 661 |
| 11 | Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 641 |
| 12 | The electronic aggregometer: A novel device for assessing platelet behavior in blood | Journal of Pharmacological Methods | 1980 | 631 |
| 13 | Pharmacological Studies on Lamotrigine, A Novel Potential Antiepileptic Drug | Epilepsia | 1986 | 518 |
| 14 | A new approach to anti-inflammatory drugs | Biochemical Pharmacology | 1979 | 509 |
| 15 | Models of the diffusional spread of nitric oxide: Implications for neural nitric oxide signalling and its pharmacological properties | Neuropharmacology | 1994 | 492 |
| 16 | Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme | Nature | 1979 | 485 |
| 17 | Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80) | Biochemical Pharmacology | 1992 | 465 |
| 18 | Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 448 |
| 19 | Specific nonopiate receptors for beta-endorphin | Science | 1979 | 443 |
| 20 | Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat | Gastroenterology | 1981 | 427 |
| 21 | The Clinical Neuromuscular Pharmacology of Mivacurium Chloride (BW B1090U). A Short-acting Nondepolarizing Ester Neuromuscular Blocking Drug | Anesthesiology | 1988 | 423 |
| 22 | Chemokinetic activity of arachidonic acid lipoxygenase products on leuocyctes of different species | Prostaglandins | 1980 | 417 |
| 23 | Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 402 |
| 24 | Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity. | Proceedings of the National Academy of Sciences of the United States of America | 1990 | 397 |
| 25 | Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir | Nature | 1992 | 393 |
| 26 | Prostacyclin is a circulating hormone | Nature | 1978 | 386 |
| 27 | DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN | Lancet, The | 1978 | 367 |
| 28 | The role of lipid intermediates in the glycosylation of proteins in the eucaryotic cell | BBA - Biomembranes | 1979 | 366 |
| 29 | Structure of a major immunogenic site on foot-and-mouth disease virus | Nature | 1993 | 360 |
| 30 | A genetic algorithm for flexible molecular overlay and pharmacophore elucidation | Journal of Computer-Aided Molecular Design | 1995 | 350 |
| 31 | On the Mechanism of Inactivation of Xanthine Oxidase by Allopurinol and Other Pyrazolo[3,4-d]pyrimidines | Journal of Biological Chemistry | 1970 | 347 |
| 32 | Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species | Prostaglandins | 1978 | 341 |
| 33 | Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors | Science | 1981 | 339 |
| 34 | Characterization of aromatic- and purine-dependent Salmonella typhimurium: attention, persistence, and ability to induce protective immunity in BALB/c mice | Infection and Immunity | 1988 | 312 |
| 35 | Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature | Neuropharmacology | 1994 | 309 |
| 36 | Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase | Neuroscience | 1995 | 307 |
| 37 | Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists. | Journal of Immunology | 1992 | 302 |
| 38 | Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 294 |
| 39 | Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes | Aids | 1991 | 282 |
| 40 | Interactions of peroxynitrite with human plasma and its constituents: oxidative damage and antioxidant depletion | Biochemical Journal | 1994 | 280 |
| 41 | Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine | Biochemistry | 1993 | 279 |
| 42 | Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists | Journal of Immunology | 1992 | 272 |
| 43 | A family of structural genes for human lymphoblastoid (leukocyte-type) interferon | Nature | 1980 | 257 |
| 44 | Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans | Clinical Pharmacology and Therapeutics | 1987 | 257 |
| 45 | Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate | Science | 1975 | 249 |
| 46 | Synaptic activation of metabotropic glutamate receptors in the parallel Fibre-Purkinje cell pathway in rat cerebellar slices | Neuroscience | 1994 | 242 |
| 47 | 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors | Antimicrobial Agents and Chemotherapy | 1992 | 241 |
| 48 | Antibodies to purified insulin receptor have insulin-like activity | Science | 1978 | 236 |
| 49 | Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 230 |
| 50 | Rapid Selection Using G418 of High Copy Number Transformants of Pichia pastoris for High–level Foreign Gene Expression | Nature Biotechnology | 1994 | 226 |
