| # | Title | Journal | Year | Citations |
|---|
| 1 | Phosphorylated CREB binds specifically to the nuclear protein CBP | Nature | 1993 | 1,978 |
| 2 | Opioids excite dopamine neurons by hyperpolarization of local interneurons | Journal of Neuroscience | 1992 | 1,472 |
| 3 | Nuclear protein CBP is a coactivator for the transcription factor CREB | Nature | 1994 | 1,429 |
| 4 | Anatomy and regulation of the central melanocortin system | Nature Neuroscience | 2005 | 1,315 |
| 5 | CBP/p300 in cell growth, transformation, and development | Genes and Development | 2000 | 1,287 |
| 6 | Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP | Nature | 1995 | 1,140 |
| 7 | Reactive astrocyte nomenclature, definitions, and future directions | Nature Neuroscience | 2021 | 1,098 |
| 8 | Furin at the cutting edge: From protein traffic to embryogenesis and disease | Nature Reviews Molecular Cell Biology | 2002 | 1,054 |
| 9 | Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH | Nature | 2007 | 979 |
| 10 | Regulatory Phosphorylation of AMPA-Type Glutamate Receptors by CaM-KII During Long-Term Potentiation | Science | 1997 | 978 |
| 11 | X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor | Nature | 2009 | 966 |
| 12 | AKAP signalling complexes: focal points in space and time | Nature Reviews Molecular Cell Biology | 2004 | 965 |
| 13 | The time course of glutamate in the synaptic cleft | Science | 1992 | 928 |
| 14 | Principles of activation and permeation in an anion-selective Cys-loop receptor | Nature | 2011 | 899 |
| 15 | Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain | Science | 1996 | 887 |
| 16 | Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus | Nature | 2000 | 880 |
| 17 | Dimers of mitochondrial ATP synthase form the permeability transition pore | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 822 |
| 18 | Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation | Neuron | 1998 | 820 |
| 19 | Mechanism of calcium gating in small-conductance calcium-activated potassium channels | Nature | 1998 | 809 |
| 20 | Flux coupling in a neuronal glutamate transporter | Nature | 1996 | 807 |
| 21 | Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation | Trends in Cell Biology | 2002 | 806 |
| 22 | Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond | Zebrafish | 2013 | 795 |
| 23 | Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor | Nature Neuroscience | 2003 | 781 |
| 24 | Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors | Science | 2018 | 773 |
| 25 | Ca2+/calmodulin-kinase II enhances channel conductance of -amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 761 |
| 26 | From The Cover: A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 750 |
| 27 | Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections | Science | 2002 | 746 |
| 28 | CREB-binding Protein and p300 in Transcriptional Regulation | Journal of Biological Chemistry | 2001 | 736 |
| 29 | Cellular and Synaptic Adaptations Mediating Opioid Dependence | Physiological Reviews | 2001 | 725 |
| 30 | Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D | Journal of Biological Chemistry | 2005 | 717 |
| 31 | The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal SynapsesIn Vitro | Journal of Neuroscience | 1999 | 705 |
| 32 | Calcium-activated potassium channels | Current Opinion in Neurobiology | 1998 | 696 |
| 33 | Subunit arrangement and function in NMDA receptors | Nature | 2005 | 694 |
| 34 | Crystal structure of the ATP-gated P2X4 ion channel in the closed state | Nature | 2009 | 680 |
| 35 | Regulation ofµ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance | Pharmacological Reviews | 2013 | 673 |
| 36 | A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity | Nature Cell Biology | 2000 | 666 |
| 37 | A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse | Endocrinology | 2000 | 637 |
| 38 | Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. | Journal of Biological Chemistry | 1992 | 630 |
| 39 | Defining the CREB RegulonA Genome-Wide Analysis of Transcription Factor Regulatory Regions | Cell | 2004 | 626 |
| 40 | Molecular basis of mechanosensory transduction | Nature | 2001 | 621 |
| 41 | PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine | Journal of Neuroscience | 1995 | 620 |
| 42 | Nonuniform probability of glutamate release at a hippocampal synapse | Science | 1993 | 610 |
| 43 | 5-HT3 receptors are membrane ion channels | Nature | 1989 | 607 |
| 44 | Regulatory mechanisms of AMPA receptors in synaptic plasticity | Nature Reviews Neuroscience | 2007 | 606 |
| 45 | Two types of neurone in the rat ventral tegmental area and their synaptic inputs. | Journal of Physiology | 1992 | 600 |
| 46 | Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A | Molecular Cell | 1999 | 593 |
| 47 | The mitochondrial permeability transition from in vitro artifact to disease target | FEBS Journal | 2006 | 591 |
| 48 | Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP | Nature | 1995 | 586 |
| 49 | AKAPs: from structure to function | Trends in Cell Biology | 1999 | 577 |
| 50 | Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway | Nature | 1998 | 572 |
