| # | Title | Journal | Year | Citations |
|---|
| 1 | Ghrelin: Structure and Function | Physiological Reviews | 2005 | 1,569 |
| 2 | A new protein containing an SH2 domain that inhibits JAK kinases | Nature | 1997 | 1,319 |
| 3 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 4 | Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction | Circulation | 2001 | 1,109 |
| 5 | Mitochondrial diseases | Nature Reviews Disease Primers | 2016 | 1,001 |
| 6 | Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease) | Nature | 2000 | 865 |
| 7 | Ghrelin | Molecular Metabolism | 2015 | 810 |
| 8 | Clinical characteristics of clear cell carcinoma of the ovary | Cancer | 2000 | 710 |
| 9 | The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop | EMBO Journal | 1999 | 638 |
| 10 | Clinical features of isolated noncompaction of the ventricular myocardium | Journal of the American College of Cardiology | 1999 | 636 |
| 11 | Requirement of CD9 on the Egg Plasma Membrane for Fertilization | Science | 2000 | 624 |
| 12 | Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity | Nature Medicine | 2004 | 564 |
| 13 | Negative Regulation of Cytokine Signaling Pathways | Annual Review of Immunology | 2000 | 562 |
| 14 | JunctophilinsA Novel Family of Junctional Membrane Complex Proteins | Molecular Cell | 2000 | 560 |
| 15 | Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer | Annals of Oncology | 2014 | 541 |
| 16 | Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy | Nature Genetics | 1997 | 540 |
| 17 | Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection | Hepatology | 2014 | 517 |
| 18 | SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality | Cell | 1999 | 485 |
| 19 | CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation | Blood | 1997 | 478 |
| 20 | Erlotinib plus bevacizumab versus erlotinib alone in patients with EGFR-positive advanced non-squamous non-small-cell lung cancer (NEJ026): interim analysis of an open-label, randomised, multicentre, phase 3 trial | Lancet Oncology, The | 2019 | 470 |
| 21 | Fate of coronary aneurysms in Kawasaki disease: Serial coronary angiography and long-term follow-up study | American Journal of Cardiology | 1982 | 451 |
| 22 | Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation | Journal of Experimental Medicine | 2001 | 446 |
| 23 | The pleiotropic functions of the Y-box-binding protein, YB-1 | BioEssays | 2003 | 444 |
| 24 | The seven countries study: 2,289 deaths in 15 years | Preventive Medicine | 1984 | 439 |
| 25 | Prediction of resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease | Journal of Pediatrics | 2006 | 437 |
| 26 | Parthenogenetic activation of oocytes in c-mos-deficient mice | Nature | 1994 | 434 |
| 27 | Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice | Nature Biotechnology | 2001 | 428 |
| 28 | Spred is a Sprouty-related suppressor of Ras signalling | Nature | 2001 | 416 |
| 29 | Narrow‐band imaging (NBI) magnifying endoscopic classification of colorectal tumors proposed by the Japan NBI Expert Team | Digestive Endoscopy | 2016 | 410 |
| 30 | Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders Constitute a Distinct Clinicopathologic Group: A Study of 96 Patients | Clinical Cancer Research | 2007 | 409 |
| 31 | Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung Cancer | Clinical Cancer Research | 2015 | 392 |
| 32 | Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma | Blood | 2015 | 390 |
| 33 | Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan | Hepatology | 2001 | 387 |
| 34 | New insights into the function and regulation of mitochondrial fission | Biochimica Et Biophysica Acta - Molecular Cell Research | 2013 | 384 |
| 35 | Kabuki make-up (Niikawa-Kuroki) syndrome: A study of 62 patients | American Journal of Medical Genetics Part A | 1988 | 373 |
| 36 | Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis | Journal of Experimental Medicine | 2009 | 361 |
| 37 | Nationwide Survey of Hemophagocytic Lymphohistiocytosis in Japan | International Journal of Hematology | 2007 | 360 |
| 38 | Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus | British Journal of Dermatology | 1999 | 357 |
| 39 | EBV-associated T/NK–cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases | Blood | 2012 | 354 |
| 40 | Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain | Genes To Cells | 1999 | 342 |
| 41 | Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 341 |
| 42 | SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis | Cell | 1999 | 339 |
| 43 | Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial | Lancet Infectious Diseases, The | 2015 | 333 |
| 44 | Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs | Clinical Cancer Research | 2006 | 324 |
| 45 | Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review | Journal of Hepatology | 2017 | 312 |
| 46 | Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7 | Journal of Biological Chemistry | 1999 | 300 |
| 47 | Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth | Journal of Clinical Investigation | 2003 | 289 |
| 48 | CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2 | Journal of Biological Chemistry | 2000 | 288 |
| 49 | Effects of hypoxia on rat hippocampal neurones in vitro. | Journal of Physiology | 1987 | 287 |
| 50 | The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2 | Journal of Biological Chemistry | 2001 | 279 |
