| Finding the missing heritability of complex diseases | Nature | 2009 | 6.1K |
| A core gut microbiome in obese and lean twins | Nature | 2009 | 5.4K |
| The B73 maize genome: complexity, diversity, and dynamics | Science | 2009 | 2.9K |
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| The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice | Science Translational Medicine | 2009 | 2K |
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| BreakDancer: an algorithm for high-resolution mapping of genomic structural variation | Nature Methods | 2009 | 1.1K |
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| The role of apolipoprotein E in Alzheimer's disease | Neuron | 2009 | 1K |
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| A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity | Nature | 2009 | 973 |
| VarScan: variant detection in massively parallel sequencing of individual and pooled samples | Bioinformatics | 2009 | 890 |
| Cell death | New England Journal of Medicine | 2009 | 863 |
| Distinct genetic influences on cortical surface area and cortical thickness | Cerebral Cortex | 2009 | 862 |
| Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis | Science | 2009 | 846 |
| Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy | Nature Reviews Neuroscience | 2009 | 809 |
| Immunogenic and tolerogenic cell death | Nature Reviews Immunology | 2009 | 779 |
| Redefining chronic viral infection | Cell | 2009 | 727 |
| Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project | Blood | 2009 | 718 |
| Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 705 |
