| # | Title | Journal | Year | Citations |
|---|
| 1 | QIIME allows analysis of high-throughput community sequencing data | Nature Methods | 2010 | 31,818 |
| 2 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | JAMA - Journal of the American Medical Association | 2016 | 16,554 |
| 3 | The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 12,681 |
| 4 | A default mode of brain function | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 10,607 |
| 5 | Control of goal-directed and stimulus-driven attention in the brain | Nature Reviews Neuroscience | 2002 | 10,175 |
| 6 | tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence | Nucleic Acids Research | 1997 | 9,417 |
| 7 | The Clinical Dementia Rating (CDR) | Neurology | 1993 | 7,882 |
| 8 | Human gut microbes associated with obesity | Nature | 2006 | 7,595 |
| 9 | Finding the missing heritability of complex diseases | Nature | 2009 | 7,490 |
| 10 | A Rating Scale for Mania: Reliability, Validity and Sensitivity | British Journal of Psychiatry | 1978 | 7,207 |
| 11 | A core gut microbiome in obese and lean twins | Nature | 2009 | 6,819 |
| 12 | Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion | NeuroImage | 2012 | 6,516 |
| 13 | Initial sequencing and comparative analysis of the mouse genome | Nature | 2002 | 6,319 |
| 14 | Human gut microbiome viewed across age and geography | Nature | 2012 | 6,247 |
| 15 | A New Clinical Scale for the Staging of Dementia | British Journal of Psychiatry | 1982 | 6,182 |
| 16 | Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 | Cancer Cell | 2010 | 6,138 |
| 17 | Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging | Nature Reviews Neuroscience | 2007 | 5,936 |
| 18 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death | Cell | 1993 | 5,865 |
| 19 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 20 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 21 | Obesity alters gut microbial ecology | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 5,247 |
| 22 | The gut microbiota as an environmental factor that regulates fat storage | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 5,131 |
| 23 | Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion | Science | 2011 | 4,987 |
| 24 | Assembly of Asparagine-Linked Oligosaccharides | Annual Review of Biochemistry | 1985 | 4,906 |
| 25 | Profile hidden Markov models | Bioinformatics | 1998 | 4,873 |
| 26 | The Human Microbiome Project | Nature | 2007 | 4,750 |
| 27 | The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases | Hepatology | 2018 | 4,738 |
| 28 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 29 | A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae | Nature | 2000 | 4,490 |
| 30 | A Psychobiological Model of Temperament and Character | Archives of General Psychiatry | 1993 | 4,451 |
| 31 | Host-Bacterial Mutualism in the Human Intestine | Science | 2005 | 4,326 |
| 32 | Cancer immunoediting: from immunosurveillance to tumor escape | Nature Immunology | 2002 | 4,290 |
| 33 | Outcomes for Implementation Research: Conceptual Distinctions, Measurement Challenges, and Research Agenda | Administration and Policy in Mental Health and Mental Health Services Research | 2011 | 4,123 |
| 34 | Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages | Nature Immunology | 2005 | 4,106 |
| 35 | Functional diversity of helper T lymphocytes | Nature | 1996 | 4,094 |
| 36 | The minimal preprocessing pipelines for the Human Connectome Project | NeuroImage | 2013 | 4,042 |
| 37 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 38 | tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence | Nucleic Acids Research | 1997 | 3,970 |
| 39 | Metagenomic Analysis of the Human Distal Gut Microbiome | Science | 2006 | 3,964 |
| 40 | Functional profiling of the Saccharomyces cerevisiae genome | Nature | 2002 | 3,938 |
| 41 | Tolerance of normal tissue to therapeutic irradiation | International Journal of Radiation Oncology Biology Physics | 1991 | 3,929 |
| 42 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 43 | Neoantigens in cancer immunotherapy | Science | 2015 | 3,809 |
| 44 | Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2016 | 3,807 |
| 45 | Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis | Science | 1999 | 3,761 |
| 46 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 47 | The Pathophysiology and Treatment of Sepsis | New England Journal of Medicine | 2003 | 3,708 |
| 48 | Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death | Nature | 1990 | 3,662 |
| 49 | The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease | Neurology | 1989 | 3,661 |
| 50 | A multi-modal parcellation of human cerebral cortex | Nature | 2016 | 3,634 |
