| # | Title | Journal | Year | Citations |
|---|
| 1 | Design and validation of a histological scoring system for nonalcoholic fatty liver disease | Hepatology | 2005 | 8,518 |
| 2 | Heart rate variability: Origins, methods, and interpretive caveats | Psychophysiology | 1997 | 2,945 |
| 3 | Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors | Biochemical Pharmacology | 1995 | 2,561 |
| 4 | Microencapsulated islets as bioartificial endocrine pancreas | Science | 1980 | 2,239 |
| 5 | Bile salt biotransformations by human intestinal bacteria | Journal of Lipid Research | 2006 | 2,129 |
| 6 | Causal Relationship Between Stressful Life Events and the Onset of Major Depression | American Journal of Psychiatry | 1999 | 2,034 |
| 7 | A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin | Biochemical Pharmacology | 1999 | 1,870 |
| 8 | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis | Nature | 1996 | 1,789 |
| 9 | Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis | Hepatology | 2007 | 1,673 |
| 10 | Current methods of the U.S. Preventive Services Task Force | American Journal of Preventive Medicine | 2001 | 1,657 |
| 11 | The Structure of Genetic and Environmental Risk Factors for Common Psychiatric and Substance Use Disorders in Men and Women | Archives of General Psychiatry | 2003 | 1,640 |
| 12 | Polypeptide with Broad Biological Activity: Isolation from Small Intestine | Science | 1970 | 1,544 |
| 13 | Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions | Intensive Care Medicine | 2006 | 1,507 |
| 14 | Leptin-regulated endocannabinoids are involved in maintaining food intake | Nature | 2001 | 1,468 |
| 15 | Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations | Intensive Care Medicine | 2007 | 1,432 |
| 16 | A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders | American Journal of Psychiatry | 2001 | 1,306 |
| 17 | Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome | Intensive Care Medicine | 2013 | 1,197 |
| 18 | Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 | Journal of Hepatology | 2018 | 1,157 |
| 19 | Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics | American Journal of Respiratory and Critical Care Medicine | 1999 | 1,109 |
| 20 | Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women | Archives of General Psychiatry | 2000 | 1,098 |
| 21 | A lipidomic analysis of nonalcoholic fatty liver disease | Hepatology | 2007 | 1,096 |
| 22 | A controlled cortical impact model of traumatic brain injury in the rat | Journal of Neuroscience Methods | 1991 | 1,066 |
| 23 | Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial | Journal of Neurosurgery | 1991 | 1,020 |
| 24 | A new model of diffuse brain injury in rats | Journal of Neurosurgery | 1994 | 1,007 |
| 25 | Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy | American Journal of Psychiatry | 1994 | 990 |
| 26 | A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia | Neurology | 1996 | 982 |
| 27 | Health-related quality of life measures for women with urinary incontinence: the Incontinence Impact Questionnaire and the Urogenital Distress Inventory | Quality of Life Research | 1994 | 949 |
| 28 | Platelet‐ and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension | FASEB Journal | 1998 | 904 |
| 29 | Stressful life events, genetic liability, and onset of an episode of major depression in women | American Journal of Psychiatry | 1995 | 901 |
| 30 | The intergroup rhabdomyosarcoma study-I.A final report | Cancer | 1988 | 853 |
| 31 | Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: A synopsis of the National Cancer Institute Thyroid Fine‐Needle Aspiration State of the Science Conference | Diagnostic Cytopathology | 2008 | 816 |
| 32 | Prevalence and Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome | Journal of Clinical Endocrinology and Metabolism | 2005 | 811 |
| 33 | Organization of endogenous opiate and nonopiate pain control systems | Science | 1982 | 799 |
| 34 | Accelerated Partial Breast Irradiation Consensus Statement From the American Society for Radiation Oncology (ASTRO) | International Journal of Radiation Oncology Biology Physics | 2009 | 797 |
| 35 | 2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction | Heart Rhythm | 2017 | 792 |
| 36 | THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE | Lancet, The | 1989 | 779 |
| 37 | Managing Incidental Findings on Abdominal CT: White Paper of the ACR Incidental Findings Committee | Journal of the American College of Radiology | 2010 | 766 |
| 38 | Toward a Comprehensive Developmental Model for Major Depression in Women | American Journal of Psychiatry | 2002 | 761 |
| 39 | Smoking and Major Depression | Archives of General Psychiatry | 1993 | 755 |
| 40 | Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions | Pain | 1995 | 743 |
| 41 | Interactions among converging sensory inputs in the superior colliculus | Science | 1983 | 739 |
| 42 | Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the Kidneys | Journal of Pharmacology and Experimental Therapeutics | 2009 | 736 |
| 43 | A Direct Effect of Hyperinsulinemia on Serum Sex Hormone-Binding Globulin Levels in Obese Women with the Polycystic Ovary Syndrome* | Journal of Clinical Endocrinology and Metabolism | 1991 | 726 |
| 44 | Tachycardia-Induced Cardiomyopathy: A Review of Animal Models and Clinical Studies | Journal of the American College of Cardiology | 1997 | 720 |
| 45 | Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis | Brain Research | 1974 | 709 |
| 46 | Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome | New England Journal of Medicine | 1996 | 696 |
| 47 | Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy | Nature Medicine | 1998 | 695 |
| 48 | Guidelines on nicotine dose selection for in vivo research | Psychopharmacology | 2007 | 694 |
| 49 | Major Depression and Generalized Anxiety Disorder | Archives of General Psychiatry | 1992 | 688 |
| 50 | Diagnosing Idiopathic Normal-pressure Hydrocephalus | Neurosurgery | 2005 | 685 |
