| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? | International Journal of Epidemiology | 2020 | 1,110 |
| 5 | Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis | Science | 1999 | 1,074 |
| 6 | Are the clinical effects of homoeopathy placebo effects? A meta-analysis of placebo-controlled trials | Lancet, The | 1997 | 964 |
| 7 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 8 | Minimum Information about a Biosynthetic Gene cluster | Nature Chemical Biology | 2015 | 715 |
| 9 | A draft genome of Yersinia pestis from victims of the Black Death | Nature | 2011 | 619 |
| 10 | Current Strategies for Brain Drug Delivery | Theranostics | 2018 | 598 |
| 11 | DNA Repair and Mutagenesis | | 2005 | 591 |
| 12 | The Effect of Directly Observed Therapy on the Rates of Drug Resistance and Relapse in Tuberculosis | New England Journal of Medicine | 1994 | 543 |
| 13 | Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases | Oxidative Medicine and Cellular Longevity | 2019 | 478 |
| 14 | The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) | American Journal of Cardiology | 2004 | 473 |
| 15 | Cocaine self-administration in dopamine-transporter knockout mice | Nature Neuroscience | 1998 | 463 |
| 16 | Mitochondrial localization of estrogen receptor | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 463 |
| 17 | The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group | Osteoporosis International | 2014 | 450 |
| 18 | Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 446 |
| 19 | Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic | Nature Reviews Neurology | 2018 | 434 |
| 20 | Global regulation by the small RNA‐binding protein CsrA and the non‐coding RNA molecule CsrB | Molecular Microbiology | 1998 | 418 |
| 21 | The RNA Molecule CsrB Binds to the Global Regulatory Protein CsrA and Antagonizes Its Activity in Escherichia coli | Journal of Biological Chemistry | 1997 | 401 |
| 22 | Biofilm Formation and Dispersal under the Influence of the Global Regulator CsrA of Escherichia coli | Journal of Bacteriology | 2002 | 385 |
| 23 | Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance | Oncogene | 2002 | 383 |
| 24 | What is Patient Safety Culture? A Review of the Literature | Journal of Nursing Scholarship | 2010 | 378 |
| 25 | Current state of Alzheimer’s fluid biomarkers | Acta Neuropathologica | 2018 | 370 |
| 26 | A novel sRNA component of the carbon storage regulatory system of Escherichia coli | Molecular Microbiology | 2003 | 364 |
| 27 | Positive regulation of motility and flhDC expression by the RNA-binding protein CsrA of Escherichia coli | Molecular Microbiology | 2001 | 359 |
| 28 | The use of neuronal networks on multielectrode arrays as biosensors | Biosensors and Bioelectronics | 1995 | 352 |
| 29 | Meta‐analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first‐line therapies for Helicobacter pylori | Alimentary Pharmacology and Therapeutics | 2007 | 342 |
| 30 | Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice | Mechanisms of Ageing and Development | 1994 | 341 |
| 31 | Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood | Epigenetics | 2011 | 331 |
| 32 | Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity | Neuron | 2007 | 321 |
| 33 | What Does Adolescent Substance Use Look Like During the COVID-19 Pandemic? Examining Changes in Frequency, Social Contexts, and Pandemic-Related Predictors | Journal of Adolescent Health | 2020 | 315 |
| 34 | Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor | Nature | 1998 | 309 |
| 35 | Expression of Cone-Photoreceptor–Specific Antigens in a Cell Line Derived from Retinal Tumors in Transgenic Mice | | 2004 | 295 |
| 36 | Drinking to cope with the pandemic: The unique associations of COVID-19-related perceived threat and psychological distress to drinking behaviors in American men and women | Addictive Behaviors | 2020 | 281 |
| 37 | A Meta-analysis of Quantitative EEG Power Associated With Attention-Deficit Hyperactivity Disorder | Journal of Clinical Neurophysiology | 2006 | 278 |
| 38 | Scientific Basis for Managing PFAS as a Chemical Class | Environmental Science and Technology Letters | 2020 | 278 |
| 39 | Visceral Fat, Waist Circumference, and BMI: Impact of Race/ethnicity | Obesity | 2008 | 273 |
| 40 | Trends in Fatalities From Distracted Driving in the United States, 1999 to 2008 | American Journal of Public Health | 2010 | 271 |
| 41 | Effect of Age and Caloric Intake on Protein Oxidation in Different Brain Regions and on Behavioral Functions of the Mouse | Archives of Biochemistry and Biophysics | 1996 | 268 |
| 42 | Biocompatibility of Mesoporous Silica Nanoparticles? | Comments on Inorganic Chemistry | 2016 | 265 |
| 43 | Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress | Journal of Diabetes Research | 2014 | 261 |
| 44 | A novel Alzheimer disease locus located near the gene encoding tau protein | Molecular Psychiatry | 2016 | 260 |
| 45 | CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli | Molecular Microbiology | 2002 | 257 |
| 46 | Cutting Edge: Lectin-Like Transcript-1 Is a Ligand for the Inhibitory Human NKR-P1A Receptor | Journal of Immunology | 2005 | 254 |
| 47 | Synthesis and degradation of cyclic ADP-ribose by NAD glycohydrolases | Science | 1993 | 253 |
| 48 | The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics | Frontiers in Pharmacology | 2013 | 250 |
| 49 | The future of blood‐based biomarkers for Alzheimer's disease | Alzheimer's and Dementia | 2014 | 250 |
| 50 | The effect of changes in cardiac output on middle cerebral artery mean blood velocity at rest and during exercise | Journal of Physiology | 2005 | 248 |
