| # | Title | Journal | Year | Citations |
|---|
| 1 | Vascular-specific growth factors and blood vessel formation | Nature | 2000 | 3,413 |
| 2 | Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis | Science | 1997 | 3,214 |
| 3 | Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy | Science | 2001 | 2,935 |
| 4 | Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo | Nature Cell Biology | 2001 | 2,153 |
| 5 | Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF | Science | 1999 | 2,020 |
| 6 | Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 | Nature | 2021 | 1,904 |
| 7 | VEGF-Trap: A VEGF blocker with potent antitumor effects | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 1,572 |
| 8 | COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses | Nature | 2020 | 1,520 |
| 9 | BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra | Nature | 1991 | 1,441 |
| 10 | Molecular cloning and expression of brain-derived neurotrophic factor | Nature | 1989 | 1,412 |
| 11 | Regulation of the Germinal Center Response by MicroRNA-155 | Science | 2007 | 1,393 |
| 12 | Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways | Nature Cell Biology | 2001 | 1,331 |
| 13 | Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1 | Science | 1999 | 1,264 |
| 14 | Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma | New England Journal of Medicine | 2018 | 1,253 |
| 15 | Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system | Nature Reviews Molecular Cell Biology | 2009 | 1,235 |
| 16 | Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies | Science | 2020 | 1,188 |
| 17 | Angiopoietin-1 protects the adult vasculature against plasma leakage | Nature Medicine | 2000 | 1,172 |
| 18 | Skeletal muscle hypertrophy and atrophy signaling pathways | International Journal of Biochemistry and Cell Biology | 2005 | 884 |
| 19 | Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 884 |
| 20 | Essential role for oncogenic Ras in tumour maintenance | Nature | 1999 | 855 |
| 21 | Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab | Angiogenesis | 2012 | 838 |
| 22 | Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting | Nature Cell Biology | 2010 | 820 |
| 23 | Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation | Nature Medicine | 2006 | 819 |
| 24 | Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials | Lancet, The | 2019 | 812 |
| 25 | Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis | Neuron | 1996 | 810 |
| 26 | Anterograde transport of brain-derived neurotrophic factor and its role in the brain | Nature | 1997 | 806 |
| 27 | The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons | Neuron | 1992 | 793 |
| 28 | Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF) | Pharmacology Biochemistry and Behavior | 1997 | 774 |
| 29 | Neurotrophic factors: from molecule to man | Trends in Neurosciences | 1994 | 773 |
| 30 | Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial | Lancet, The | 2016 | 760 |
| 31 | Ghrelin controls hippocampal spine synapse density and memory performance | Nature Neuroscience | 2006 | 738 |
| 32 | Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt | Science | 1999 | 730 |
| 33 | Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease | Immunity | 2008 | 725 |
| 34 | New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF | Oncogene | 1999 | 704 |
| 35 | Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts | American Journal of Pathology | 2004 | 702 |
| 36 | A BDNF autocrine loop in adult sensory neurons prevents cell death | Nature | 1995 | 697 |
| 37 | Increased Vascularization in Mice Overexpressing Angiopoietin-1 | Science | 1998 | 695 |
| 38 | Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity | Science | 1994 | 680 |
| 39 | Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture | Neuron | 1990 | 663 |
| 40 | Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis | JAMA - Journal of the American Medical Association | 2016 | 628 |
| 41 | Multiple knockout mouse models reveal lincRNAs are required for life and brain development | ELife | 2013 | 609 |
| 42 | Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor | Nature | 1989 | 604 |
| 43 | Signalling pathways that mediate skeletal muscle hypertrophy and atrophy | Nature Cell Biology | 2003 | 585 |
| 44 | Role of interleukin-1β during pain and inflammation | Brain Research Reviews | 2009 | 557 |
| 45 | Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 552 |
| 46 | Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands | Nature | 1996 | 513 |
| 47 | RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes | Cell Metabolism | 2016 | 511 |
| 48 | During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation | Journal of Cell Biology | 2009 | 499 |
| 49 | Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 | JAMA - Journal of the American Medical Association | 2021 | 498 |
| 50 | Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial | Lancet, The | 2016 | 471 |
