| # | Title | Journal | Year | Citations |
|---|
| 1 | C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus | JAMA - Journal of the American Medical Association | 2001 | 3,562 |
| 2 | Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease | New England Journal of Medicine | 2006 | 2,476 |
| 3 | Neuropathological Alterations in Alzheimer Disease | Cold Spring Harbor Perspectives in Medicine | 2011 | 2,365 |
| 4 | Associations Between End-of-Life Discussions, Patient Mental Health, Medical Care Near Death, and Caregiver Bereavement Adjustment | JAMA - Journal of the American Medical Association | 2008 | 2,213 |
| 5 | Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage | Annual Review of Neuroscience | 2009 | 1,562 |
| 6 | Effect of Statin Therapy on C-Reactive Protein Levels | JAMA - Journal of the American Medical Association | 2001 | 1,458 |
| 7 | The PI3K Pathway As Drug Target in Human Cancer | Journal of Clinical Oncology | 2010 | 1,114 |
| 8 | SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia | New England Journal of Medicine | 2011 | 1,021 |
| 9 | Regulation of Telomerase by Telomeric Proteins | Annual Review of Biochemistry | 2004 | 721 |
| 10 | Improved Cardiac Risk Assessment With Noninvasive Measures of Coronary Flow Reserve | Circulation | 2011 | 710 |
| 11 | Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors | Journal of Clinical Oncology | 2012 | 635 |
| 12 | Digital inequalities and why they matter | Information, Communication and Society | 2015 | 582 |
| 13 | Apixaban versus Enoxaparin for Thromboprophylaxis in Medically Ill Patients | New England Journal of Medicine | 2011 | 512 |
| 14 | Simulation-Based Trial of Surgical-Crisis Checklists | New England Journal of Medicine | 2013 | 493 |
| 15 | Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities | New England Journal of Medicine | 2011 | 468 |
| 16 | Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3 | Journal of Clinical Oncology | 2010 | 442 |
| 17 | Early Invasive vs Conservative Treatment Strategies in Women and Men With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction | JAMA - Journal of the American Medical Association | 2008 | 401 |
| 18 | Control of Human Viral Infections by Natural Killer Cells | Annual Review of Immunology | 2013 | 391 |
| 19 | Characterization of Indeterminate (Lipid-poor) Adrenal Masses: Use of Washout Characteristics at Contrast-enhanced CT | Radiology | 2000 | 374 |
| 20 | Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities | Transfusion | 2006 | 302 |
| 21 | β-Adrenergic Receptor Polymorphisms and Response to Salmeterol | American Journal of Respiratory and Critical Care Medicine | 2006 | 293 |
| 22 | Targeting Phospholamban by Gene Transfer in Human Heart Failure | Circulation | 2002 | 261 |
| 23 | Prospective Study of Bevacizumab Plus Temozolomide in Patients With Advanced Neuroendocrine Tumors | Journal of Clinical Oncology | 2012 | 257 |
| 24 | Pertuzumab Monotherapy After Trastuzumab-Based Treatment and Subsequent Reintroduction of Trastuzumab: Activity and Tolerability in Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer | Journal of Clinical Oncology | 2012 | 221 |
| 25 | Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer’s disease | Neurology | 1999 | 219 |
| 26 | Use of Video to Facilitate End-of-Life Discussions With Patients With Cancer: A Randomized Controlled Trial | Journal of Clinical Oncology | 2010 | 215 |
| 27 | Basilar Artery Occlusive Disease in the New England Medical Center Posterior Circulation Registry | Archives of Neurology | 2004 | 209 |
| 28 | Development of an IgG4-RD Responder Index | International Journal of Rheumatology | 2012 | 201 |
| 29 | Beyond validation: getting health apps into clinical practice | Npj Digital Medicine | 2020 | 196 |
| 30 | Residents Report on Adverse Events and Their Causes | Archives of Internal Medicine | 2005 | 191 |
| 31 | Flat-Panel Volume CT: Fundamental Principles, Technology, and Applications | Radiographics | 2008 | 185 |
| 32 | Automatic Patient Centering for MDCT: Effect on Radiation Dose | American Journal of Roentgenology | 2007 | 179 |
| 33 | Clinical Diagnosis by Whole-Genome Sequencing of a Prenatal Sample | New England Journal of Medicine | 2012 | 174 |
| 34 | Natural History of Experimental Coronary Atherosclerosis and Vascular Remodeling in Relation to Endothelial Shear Stress | Circulation | 2010 | 168 |
| 35 | Cross Validation of the Current Opioid Misuse Measure to Monitor Chronic Pain Patients on Opioid Therapy | Clinical Journal of Pain | 2010 | 167 |
| 36 | Vitamin D, respiratory infections, and asthma | Current Allergy and Asthma Reports | 2009 | 161 |
| 37 | Prediction of MLH1 and MSH2 Mutations in Lynch Syndrome | JAMA - Journal of the American Medical Association | 2006 | 160 |
| 38 | Serum Levels of the Interleukin-1 Receptor Family Member ST2, Cardiac Structure and Function, and Long-Term Mortality in Patients With Acute Dyspnea | Circulation: Heart Failure | 2009 | 160 |
| 39 | Early pregnancy vitamin D status and risk of preeclampsia | Journal of Clinical Investigation | 2016 | 160 |
| 40 | Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway by Nanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma | Molecular Cancer Therapeutics | 2010 | 156 |
| 41 | Comorbidity and Mortality Results From a Randomized Prostate Cancer Screening Trial | Journal of Clinical Oncology | 2011 | 150 |
| 42 | Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults | American Journal of Physiology - Endocrinology and Metabolism | 2007 | 148 |
| 43 | Physical Exertion, Exercise, and Sudden Cardiac Death in Women | JAMA - Journal of the American Medical Association | 2006 | 146 |
| 44 | Does This Patient With Liver Disease Have Cirrhosis? | JAMA - Journal of the American Medical Association | 2012 | 146 |
| 45 | Iodinated Contrast Opacification Gradients in Normal Coronary Arteries Imaged With Prospectively ECG-Gated Single Heart Beat 320-Detector Row Computed Tomography | Circulation: Cardiovascular Imaging | 2010 | 138 |
| 46 | Communicating Genetic Risk Information for Common Disorders in the Era of Genomic Medicine | Annual Review of Genomics and Human Genetics | 2013 | 135 |
| 47 | Animal models of ulcerative colitis and their application in drug research | Drug Design, Development and Therapy | 2013 | 132 |
| 48 | The Invisible Epidemic: Neglected Chronic Disease Management During COVID-19 | Journal of General Internal Medicine | 2020 | 129 |
| 49 | How many sunsets? Timing of surgery in adhesive small bowel obstruction | Journal of Trauma and Acute Care Surgery | 2013 | 127 |
| 50 | EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice | Surgical Endoscopy and Other Interventional Techniques | 2019 | 125 |
